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Volumn 16, Issue 1, 2014, Pages 48-56

Dipeptidyl peptidase-4 inhibitors and pancreatitis risk: A meta-analysis of randomized clinical trials

Author keywords

Antidiabetic drug; Meta analysis; Type 2 diabetes

Indexed keywords

ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DUTOGLIPTIN; LINAGLIPTIN; SAXAGLIPTIN; SITAGLIPTIN; VILDAGLIPTIN;

EID: 84890564960     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12176     Document Type: Article
Times cited : (84)

References (88)
  • 1
    • 84866268783 scopus 로고    scopus 로고
    • Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB et al. Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012; 35: 1364-1379.
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 2
    • 84863309250 scopus 로고    scopus 로고
    • Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis
    • Deacon CF, Mannucci E, Ahrén B. Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis. Diabetes Obes Metab 2012; 14: 762-767.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 762-767
    • Deacon, C.F.1    Mannucci, E.2    Ahrén, B.3
  • 3
    • 84876063836 scopus 로고    scopus 로고
    • Glucagon-like peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study
    • Singh S, Chang HY, Richards TM, Weiner JP, Clark JM, Segal JB. Glucagon-like peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med 2013; 173: 534-539.
    • (2013) JAMA Intern Med , vol.173 , pp. 534-539
    • Singh, S.1    Chang, H.Y.2    Richards, T.M.3    Weiner, J.P.4    Clark, J.M.5    Segal, J.B.6
  • 4
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011; 141: 150-156.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 5
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: is blinding necessary?
    • Jadad AR, Moore RA, Carroll D et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 7
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 8
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 9
    • 69149107165 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • PRISMA Group. W64.
    • Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151: 264-269, W64.
    • (2009) Ann Intern Med , vol.151 , pp. 264-269
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 10
    • 77950880269 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials
    • Monami M, Iacomelli I, Marchionni N, Mannucci E. Dipeptidyl peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 2010; 20: 224-235.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , pp. 224-235
    • Monami, M.1    Iacomelli, I.2    Marchionni, N.3    Mannucci, E.4
  • 11
    • 77951069227 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes
    • Williams-Herman D, Engel SS, Round E et al. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10, 246 patients with type 2 diabetes. BMC Endocr Disord 2010; 10: 7.
    • (2010) BMC Endocr Disord , vol.10 , pp. 7
    • Williams-Herman, D.1    Engel, S.S.2    Round, E.3
  • 13
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold CK. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin 2009; 25: 1019-1027.
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold, C.K.3
  • 14
    • 79951704452 scopus 로고    scopus 로고
    • Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis
    • Garg R, Chen W, Pendergrass M. Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis. Diabetes Care 2010; 33: 2349-2354.
    • (2010) Diabetes Care , vol.33 , pp. 2349-2354
    • Garg, R.1    Chen, W.2    Pendergrass, M.3
  • 15
    • 77952692112 scopus 로고    scopus 로고
    • Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis
    • Engel SS, Williams-Herman DE, Golm GT et al. Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis. Int J Clin Pract 2010; 64: 984-990.
    • (2010) Int J Clin Pract , vol.64 , pp. 984-990
    • Engel, S.S.1    Williams-Herman, D.E.2    Golm, G.T.3
  • 16
    • 84890546710 scopus 로고    scopus 로고
    • Available from URL: http://www.clinicaltrials.gov.
  • 17
    • 84862645734 scopus 로고    scopus 로고
    • Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial
    • Kutoh E, Ukai Y. Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial. Endocrine 2012; 41: 435-441.
    • (2012) Endocrine , vol.41 , pp. 435-441
    • Kutoh, E.1    Ukai, Y.2
  • 18
    • 84859463659 scopus 로고    scopus 로고
    • Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomized double-blind placebo-controlled study
    • Eliasson B, Möller-Goede D, Eeg-Olofsson K et al. Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomized double-blind placebo-controlled study. Diabetologia 2012; 55: 915-925.
    • (2012) Diabetologia , vol.55 , pp. 915-925
    • Eliasson, B.1    Möller-Goede, D.2    Eeg-Olofsson, K.3
  • 19
    • 70349314675 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Alogliptin Study 009 Group
    • Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q, Alogliptin Study 009 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 2009; 25: 2361-2371.
    • (2009) Curr Med Res Opin , vol.25 , pp. 2361-2371
    • Pratley, R.E.1    Reusch, J.E.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 20
    • 84860711211 scopus 로고    scopus 로고
    • Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Burant CF, Fleck P, Wilson C, Mekki Q, Pratley RE. Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes. J Clin Endocrinol Metab 2012; 97: 1615-1622.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1615-1622
    • DeFronzo, R.A.1    Burant, C.F.2    Fleck, P.3    Wilson, C.4    Mekki, Q.5    Pratley, R.E.6
  • 21
    • 70450173642 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia
    • Rosenstock J, Rendell MS, Gross JL, Fleck PR, Wilson CA, Mekki Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab 2009; 11: 1145-1152.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1145-1152
    • Rosenstock, J.1    Rendell, M.S.2    Gross, J.L.3    Fleck, P.R.4    Wilson, C.A.5    Mekki, Q.6
  • 22
    • 58149171060 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study
    • Alogliptin Study 010 Group
    • DeFronzo RA, Fleck PR, Wilson CA, Mekki Q, Alogliptin Study 010 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study. Diabetes Care 2008; 31: 2315-2317.
    • (2008) Diabetes Care , vol.31 , pp. 2315-2317
    • DeFronzo, R.A.1    Fleck, P.R.2    Wilson, C.A.3    Mekki, Q.4
  • 23
    • 58149335320 scopus 로고    scopus 로고
    • Alogliptin Study 007 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy
    • Pratley RE, Kipnes MS, Fleck PR, Wilson C, Mekki Q. Alogliptin Study 007 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. Diabetes Obes Metab 2009; 11: 167-176.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 167-176
    • Pratley, R.E.1    Kipnes, M.S.2    Fleck, P.R.3    Wilson, C.4    Mekki, Q.5
  • 24
    • 57649225147 scopus 로고    scopus 로고
    • Alogliptin Study 008 Group. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study
    • Nauck MA, Ellis GC, Fleck PR, Wilson CA, Mekki Q. Alogliptin Study 008 Group. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract 2009; 63: 46-55.
    • (2009) Int J Clin Pract , vol.63 , pp. 46-55
    • Nauck, M.A.1    Ellis, G.C.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 25
    • 79951699944 scopus 로고    scopus 로고
    • Initial combination therapy with alogliptin and pioglitazone in drug-naïve patients with type 2 diabetes
    • Rosenstock J, Inzucchi SE, Seufert J, Fleck PR, Wilson CA, Mekki Q. Initial combination therapy with alogliptin and pioglitazone in drug-naïve patients with type 2 diabetes. Diabetes Care 2010; 33: 2406-2408.
    • (2010) Diabetes Care , vol.33 , pp. 2406-2408
    • Rosenstock, J.1    Inzucchi, S.E.2    Seufert, J.3    Fleck, P.R.4    Wilson, C.A.5    Mekki, Q.6
  • 26
    • 80055037047 scopus 로고    scopus 로고
    • Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study
    • Bosi E, Ellis GC, Wilson CA, Fleck PR. Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study. Diabetes Obes Metab 2011 Dec; 13: 1088-1096.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 1088-1096
    • Bosi, E.1    Ellis, G.C.2    Wilson, C.A.3    Fleck, P.R.4
  • 27
    • 77950122844 scopus 로고    scopus 로고
    • Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week,double-blind, randomized, placebo-controlled, multicentre trial
    • Pattzi HM, Pitale S, Alpizar M et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab 2010; 12: 348-355.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 348-355
    • Pattzi, H.M.1    Pitale, S.2    Alpizar, M.3
  • 28
    • 84858003503 scopus 로고    scopus 로고
    • Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study
    • Kawamori R, Inagaki N, Araki E et al. Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study. Diabetes Obes Metab 2012; 14: 348-357.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 348-357
    • Kawamori, R.1    Inagaki, N.2    Araki, E.3
  • 29
    • 84866183265 scopus 로고    scopus 로고
    • Efficacy and tolerability of linagliptin added to a sulfonylurea regimen in patients with inadequately controlled type 2 diabetes mellitus: an 18-week, multicenter, randomized, double-blind, placebo-controlled trial
    • e15.
    • Lewin AJ, Arvay L, Liu D, Patel S, von Eynatten M, Woerle HJ. Efficacy and tolerability of linagliptin added to a sulfonylurea regimen in patients with inadequately controlled type 2 diabetes mellitus: an 18-week, multicenter, randomized, double-blind, placebo-controlled trial. Clin Ther 2012; 34: 1909-1919, e15.
    • (2012) Clin Ther , vol.34 , pp. 1909-1919
    • Lewin, A.J.1    Arvay, L.2    Liu, D.3    Patel, S.4    von Eynatten, M.5    Woerle, H.J.6
  • 30
    • 79953174825 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Gomis R, Espadero RM, Jones R, Woerle HJ, Dugi KA. Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 2011; 13: 653-661.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 653-661
    • Gomis, R.1    Espadero, R.M.2    Jones, R.3    Woerle, H.J.4    Dugi, K.A.5
  • 31
    • 78851472527 scopus 로고    scopus 로고
    • Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial
    • Del Prato S, Barnett AH, Huisman H, Neubacher D, Woerle HJ, Dugi KA. Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab 2011; 13: 258-267.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 258-267
    • Del Prato, S.1    Barnett, A.H.2    Huisman, H.3    Neubacher, D.4    Woerle, H.J.5    Dugi, K.A.6
  • 32
    • 80053072352 scopus 로고    scopus 로고
    • Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study
    • Owens DR, Swallow R, Dugi KA, Woerle HJ. Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet Med 2011; 28: 1352-1361.
    • (2011) Diabet Med , vol.28 , pp. 1352-1361
    • Owens, D.R.1    Swallow, R.2    Dugi, K.A.3    Woerle, H.J.4
  • 33
    • 84864757433 scopus 로고    scopus 로고
    • 2-Year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial
    • Gallwitz B, Rosenstock J, Rauch T et al. 2-Year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet 2012; 380: 475-483.
    • (2012) Lancet , vol.380 , pp. 475-483
    • Gallwitz, B.1    Rosenstock, J.2    Rauch, T.3
  • 34
    • 84862813117 scopus 로고    scopus 로고
    • Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Haak T, Meinicke T, Jones R, Weber S, von Eynatten M, Woerle HJ. Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 2012; 14: 565-574.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 565-574
    • Haak, T.1    Meinicke, T.2    Jones, R.3    Weber, S.4    von Eynatten, M.5    Woerle, H.J.6
  • 36
    • 79955015666 scopus 로고    scopus 로고
    • CV181039 Investigators. Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks
    • Pfützner A, Paz-Pacheco E, Allen E, Frederich R, Chen R. CV181039 Investigators. Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks. Diabetes Obes Metab 2011; 13: 567-576.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 567-576
    • Pfützner, A.1    Paz-Pacheco, E.2    Allen, E.3    Frederich, R.4    Chen, R.5
  • 37
    • 81255160603 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial
    • Yang W, Pan CY, Tou C, Zhao J, Gause-Nilsson I. Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Res Clin Pract 2011; 94: 217-224.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 217-224
    • Yang, W.1    Pan, C.Y.2    Tou, C.3    Zhao, J.4    Gause-Nilsson, I.5
  • 38
    • 84863230449 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial
    • Pan CY, Yang W, Tou C, Gause-Nilsson I, Zhao J. Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Metab Res Rev 2012; 28: 268-275.
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 268-275
    • Pan, C.Y.1    Yang, W.2    Tou, C.3    Gause-Nilsson, I.4    Zhao, J.5
  • 39
    • 70349333861 scopus 로고    scopus 로고
    • Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes
    • Rosenstock J, Aguilar-Salinas C, Klein E et al. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes. Curr Med Res Opin 2009; 25: 2401-2411.
    • (2009) Curr Med Res Opin , vol.25 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3
  • 40
    • 84859731126 scopus 로고    scopus 로고
    • Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    • Barnett AH, Charbonnel B, Donovan M, Fleming D, Chen R. Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin. Curr Med Res Opin 2012; 28: 513-523.
    • (2012) Curr Med Res Opin , vol.28 , pp. 513-523
    • Barnett, A.H.1    Charbonnel, B.2    Donovan, M.3    Fleming, D.4    Chen, R.5
  • 41
    • 79959217544 scopus 로고    scopus 로고
    • Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus
    • CV181013 Investigators
    • Hollander PL, Li J, Frederich R, Allen E, Chen R, CV181013 Investigators. Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus. Diab Vasc Dis Res 2011; 8: 125-135.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 125-135
    • Hollander, P.L.1    Li, J.2    Frederich, R.3    Allen, E.4    Chen, R.5
  • 42
    • 79959211974 scopus 로고    scopus 로고
    • CV181040 Investigators. Safety and efficacy of saxagliptin in combination with submaximal sulphonylurea versus up-titrated sulphonylurea over 76 weeks
    • Chacra AR, Tan GH, Ravichandran S, List J, Chen R. CV181040 Investigators. Safety and efficacy of saxagliptin in combination with submaximal sulphonylurea versus up-titrated sulphonylurea over 76 weeks. Diab Vasc Dis Res 2011; 8: 150-159.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 150-159
    • Chacra, A.R.1    Tan, G.H.2    Ravichandran, S.3    List, J.4    Chen, R.5
  • 43
    • 84862271963 scopus 로고    scopus 로고
    • Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial
    • Aschner P, Chan J, Owens DR et al. Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial. Lancet 2012; 379: 2262-2269.
    • (2012) Lancet , vol.379 , pp. 2262-2269
    • Aschner, P.1    Chan, J.2    Owens, D.R.3
  • 44
    • 77952316298 scopus 로고    scopus 로고
    • Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controller type 2 diabetes mellitus patients
    • Derosa G, Maffioli P, Salvadeo SA et al. Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controller type 2 diabetes mellitus patients. Metabolism 2010; 59: 887-895.
    • (2010) Metabolism , vol.59 , pp. 887-895
    • Derosa, G.1    Maffioli, P.2    Salvadeo, S.A.3
  • 45
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • Rosenstock J, Aggarwal N, Polidori D et al. Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care 2012; 35: 1232-1238.
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3
  • 46
    • 77954197187 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial
    • Iwamoto Y, Tajima N, Kadowaki T et al. Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial. Diabetes Obes Metab 2010; 12: 613-622.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 613-622
    • Iwamoto, Y.1    Tajima, N.2    Kadowaki, T.3
  • 47
    • 84864373418 scopus 로고    scopus 로고
    • Comparison between sitagliptin as add-on therapy to insulin and insulin dose-increase therapy in uncontrolled Korean type 2 diabetes: CSI study
    • Hong ES, Khang AR, Yoon JW et al. Comparison between sitagliptin as add-on therapy to insulin and insulin dose-increase therapy in uncontrolled Korean type 2 diabetes: CSI study. Diabetes Obes Metab 2012; 14: 795-802.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 795-802
    • Hong, E.S.1    Khang, A.R.2    Yoon, J.W.3
  • 48
    • 79954508355 scopus 로고    scopus 로고
    • Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
    • Barzilai N, Guo H, Mahoney EM et al. Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Curr Med Res Opin 2011; 27: 1049-1058.
    • (2011) Curr Med Res Opin , vol.27 , pp. 1049-1058
    • Barzilai, N.1    Guo, H.2    Mahoney, E.M.3
  • 49
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Sitagliptin Study 019 Group
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P, Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2006; 28: 1556-1568.
    • (2006) Clin Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 50
    • 34547863123 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor,sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Hermansen K, Kipnes M, Luo E et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab 2007; 9: 733-745.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3
  • 51
    • 84863311010 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with sitagliptin and pioglitazone in patients with type 2 diabetes: a 54-week study
    • Yoon KH, Steinberg H, Teng R et al. Efficacy and safety of initial combination therapy with sitagliptin and pioglitazone in patients with type 2 diabetes: a 54-week study. Diabetes Obes Metab 2012; 14: 745-752.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 745-752
    • Yoon, K.H.1    Steinberg, H.2    Teng, R.3
  • 52
    • 73349119110 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
    • Vilsbøll T, Rosenstock J, Yki-Järvinen H et al. Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab 2010; 12: 167-177.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 167-177
    • Vilsbøll, T.1    Rosenstock, J.2    Yki-Järvinen, H.3
  • 53
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Sitagliptin Study 020 Group
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G, Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006; 29: 2638-2643.
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 54
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006; 29: 2632-2637.
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 55
    • 39749184723 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes
    • Raz I, Chen Y, Wu M et al. Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin 2008; 24: 537-550.
    • (2008) Curr Med Res Opin , vol.24 , pp. 537-550
    • Raz, I.1    Chen, Y.2    Wu, M.3
  • 56
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006; 49: 2564-2571.
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 57
    • 84866179187 scopus 로고    scopus 로고
    • Sitagliptin exerts an antinflammatory action
    • Makdissi A, Ghanim H, Vora M et al. Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab 2012; 97: 3333-3341.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3333-3341
    • Makdissi, A.1    Ghanim, H.2    Vora, M.3
  • 58
    • 84869798707 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial evaluating sitagliptin action on insulin resistance parameters and β-cell function
    • Derosa G, Carbone A, D'Angelo A et al. A randomized, double-blind, placebo-controlled trial evaluating sitagliptin action on insulin resistance parameters and β-cell function. Expert Opin Pharmacother 2012; 13: 2433-2442.
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 2433-2442
    • Derosa, G.1    Carbone, A.2    D'Angelo, A.3
  • 59
    • 45449105789 scopus 로고    scopus 로고
    • Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency
    • Chan JC, Scott R, Arjona Ferreira JC et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab 2008; 10: 545-555.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 545-555
    • Chan, J.C.1    Scott, R.2    Arjona Ferreira, J.C.3
  • 60
    • 77952083721 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes
    • Williams-Herman D, Johnson J, Teng R et al. Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes. Diabetes Obes Metab 2010; 12: 442-451.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 442-451
    • Williams-Herman, D.1    Johnson, J.2    Teng, R.3
  • 61
    • 84863791439 scopus 로고    scopus 로고
    • The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients
    • Koren S, Shemesh-Bar L, Tirosh A et al. The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients. Diabetes Technol Ther 2012; 14: 561-567.
    • (2012) Diabetes Technol Ther , vol.14 , pp. 561-567
    • Koren, S.1    Shemesh-Bar, L.2    Tirosh, A.3
  • 62
    • 84859040910 scopus 로고    scopus 로고
    • Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone
    • Srivastava S, Saxena GN, Keshwani P, Gupta R. Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone. J Assoc Physicians India. 2012; 60: 27-30.
    • (2012) J Assoc Physicians India. , vol.60 , pp. 27-30
    • Srivastava, S.1    Saxena, G.N.2    Keshwani, P.3    Gupta, R.4
  • 63
    • 78650656671 scopus 로고    scopus 로고
    • Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial
    • Arechavaleta R, Seck T, Chen Y et al. Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 2011; 13: 160-168.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 160-168
    • Arechavaleta, R.1    Seck, T.2    Chen, Y.3
  • 64
    • 77949387699 scopus 로고    scopus 로고
    • Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study
    • Seck T, Nauck M, Sheng D et al. Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study. Int J Clin Pract 2010; 64: 562-576.
    • (2010) Int J Clin Pract , vol.64 , pp. 562-576
    • Seck, T.1    Nauck, M.2    Sheng, D.3
  • 65
    • 84859444408 scopus 로고    scopus 로고
    • Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes
    • Wainstein J, Katz L, Engel SS et al. Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 2012; 14: 409-418.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 409-418
    • Wainstein, J.1    Katz, L.2    Engel, S.S.3
  • 66
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study
    • Russell-Jones D, Cuddihy RM, Hanefeld M et al. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care 2012; 35: 252-258.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 67
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    • Bergenstal RM, Wysham C, Macconell L et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010; 376: 431-439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3
  • 68
    • 41749106662 scopus 로고    scopus 로고
    • Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial
    • Pan C, Yang W, Barona JP et al. Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial. Diabet Med 2008; 25: 435-441.
    • (2008) Diabet Med , vol.25 , pp. 435-441
    • Pan, C.1    Yang, W.2    Barona, J.P.3
  • 69
    • 67649933635 scopus 로고    scopus 로고
    • Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    • Schweizer A, Dejager S, Bosi E. Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Obes Metab 2009; 11: 804-812.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 804-812
    • Schweizer, A.1    Dejager, S.2    Bosi, E.3
  • 70
    • 77955428835 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with Type 2 diabetes mellitus
    • Kikuchi M, Haneda M, Koya D et al. Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with Type 2 diabetes mellitus. Diabetes Res Clin Pract 2010; 89: 216-223.
    • (2010) Diabetes Res Clin Pract , vol.89 , pp. 216-223
    • Kikuchi, M.1    Haneda, M.2    Koya, D.3
  • 71
  • 72
    • 67949105103 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    • Goodman M, Thurston H, Penman J. Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Horm Metab Res 2009; 41: 368-373.
    • (2009) Horm Metab Res , vol.41 , pp. 368-373
    • Goodman, M.1    Thurston, H.2    Penman, J.3
  • 73
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract 2007; 76: 132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 74
    • 84863312882 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus
    • Pan C, Xing X, Han P et al. Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus. Diabetes Obes Metab 2012; 14: 737-744.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 737-744
    • Pan, C.1    Xing, X.2    Han, P.3
  • 75
    • 54249106294 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea
    • Garber AJ, Foley JE, Banerji MA et al. Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes Obes Metab 2008; 10: 1047-1056.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1047-1056
    • Garber, A.J.1    Foley, J.E.2    Banerji, M.A.3
  • 76
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007; 30: 890-895.
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 77
    • 33847687205 scopus 로고    scopus 로고
    • Vildagliptin in drug-naïve patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study
    • Dejager S, Razac S, Foley JE, Schweizer A. Vildagliptin in drug-naïve patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res 2007; 39: 218-223.
    • (2007) Horm Metab Res , vol.39 , pp. 218-223
    • Dejager, S.1    Razac, S.2    Foley, J.E.3    Schweizer, A.4
  • 78
    • 84861128717 scopus 로고    scopus 로고
    • Effects of vildagliptin on postprandial markers of bone resorption and calcium homeostasis in recently diagnosed, well-controlled type 2 diabetes patients
    • Bunck MC, Poelma M, Eekhoff EM et al. Effects of vildagliptin on postprandial markers of bone resorption and calcium homeostasis in recently diagnosed, well-controlled type 2 diabetes patients. J Diabetes 2012; 4: 181-185.
    • (2012) J Diabetes , vol.4 , pp. 181-185
    • Bunck, M.C.1    Poelma, M.2    Eekhoff, E.M.3
  • 79
    • 84861982613 scopus 로고    scopus 로고
    • Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients
    • Derosa G, Ragonesi PD, Carbone A et al. Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients. Diabetes Technol Ther 2012; 14: 475-484.
    • (2012) Diabetes Technol Ther , vol.14 , pp. 475-484
    • Derosa, G.1    Ragonesi, P.D.2    Carbone, A.3
  • 80
    • 44949170696 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia
    • Scherbaum WA, Schweizer A, Mari A et al. Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes Metab 2008; 10: 675-682.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 675-682
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3
  • 81
    • 84867142621 scopus 로고    scopus 로고
    • One-year safety, tolerability and efficacy of vildagliptin in patients with type 2 diabetes and moderate or severe renal impairment
    • Kothny W, Shao Q, Groop PH, Lukashevich V. One-year safety, tolerability and efficacy of vildagliptin in patients with type 2 diabetes and moderate or severe renal impairment. Diabetes Obes Metab 2012; 14: 1032-1039.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 1032-1039
    • Kothny, W.1    Shao, Q.2    Groop, P.H.3    Lukashevich, V.4
  • 82
    • 71849095372 scopus 로고    scopus 로고
    • Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes
    • Foley JE, Sreenan S. Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes. Horm Metab Res 2009; 41: 905-909.
    • (2009) Horm Metab Res , vol.41 , pp. 905-909
    • Foley, J.E.1    Sreenan, S.2
  • 83
    • 77949356196 scopus 로고    scopus 로고
    • A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study
    • Filozof C, Gautier JF. A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study. Diabet Med 2010; 27: 318-326.
    • (2010) Diabet Med , vol.27 , pp. 318-326
    • Filozof, C.1    Gautier, J.F.2
  • 84
    • 58149330590 scopus 로고    scopus 로고
    • Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    • Ferrannini E, Fonseca V, Zinman B et al. Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metab 2009; 11: 157-166.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 157-166
    • Ferrannini, E.1    Fonseca, V.2    Zinman, B.3
  • 85
    • 65549131200 scopus 로고    scopus 로고
    • Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin
    • Bolli G, Dotta F, Colin L, Minic B, Goodman M. Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Obes Metab 2009; 11: 589-595.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 589-595
    • Bolli, G.1    Dotta, F.2    Colin, L.3    Minic, B.4    Goodman, M.5
  • 86
    • 65549109984 scopus 로고    scopus 로고
    • Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus
    • Rosenstock J, Niggli M, Maldonado-Lutomirsky M. Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus. Diabetes Obes Metab 2009; 11: 571-578.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 571-578
    • Rosenstock, J.1    Niggli, M.2    Maldonado-Lutomirsky, M.3
  • 87
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J, Kim SW, Baron MA et al. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 2007; 9: 175-185.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175-185
    • Rosenstock, J.1    Kim, S.W.2    Baron, M.A.3
  • 88
    • 65449135133 scopus 로고    scopus 로고
    • Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus
    • Bosi E, Dotta F, Jia Y, Goodman M. Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus. Diabetes Obes Metab 2009; 11: 506-515.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 506-515
    • Bosi, E.1    Dotta, F.2    Jia, Y.3    Goodman, M.4


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