Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients

Calcified Tissue International

Volumn 98, Issue 1, 2016, Pages 67-75

  Gulin, Tonko ^a   Kruljac, Ivan ^a   Kirigin, Lora ^a   Merc, Marcela ^a   Pavić, Marina ^a   Trcin, Mirna Tominac ^a   Bokulić, Adrijana ^a   Megla, Željka Bukovec ^a   Kaštelan, Darko ^b  

^a SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^b KBC Zagreb   (Croatia)

Author keywords

Age; eGFR; Hip fractures; One year mortality; Renal function; Risk factors; CTX

Indexed keywords

ALBUMIN; BETA ISOMERISED C TERMINAL TELOPEPTIDE OF COLLAGEN TYPE I; C REACTIVE PROTEIN; CALCIUM; CALCIUM PHOSPHATE; CARBOXY TERMINAL TELOPEPTIDE; CREATININE; D DIMER; ELECTROLYTE; EPIDERMAL GROWTH FACTOR RECEPTOR; HEMOGLOBIN; OSTEOCALCIN; UNCLASSIFIED DRUG; UREA; COLLAGEN TYPE 1;

AGE; AGED; AGING; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD CELL COUNT; BODY MASS; BONE DENSITY; BONE NAIL; CALCIUM BLOOD LEVEL; CANNULATED SCREW; COMORBIDITY; COMPARATIVE STUDY; CONSERVATIVE TREATMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE CLASSIFICATION; ELECTROCARDIOGRAPHY; ELECTROLYTE BLOOD LEVEL; FEMALE; FEMORAL HEAD FRACTURE; FEMUR FRACTURE; FEMUR NECK FRACTURE; FEMUR PERTROCHANTERIC FRACTURE; FEMUR SUBTROCHANTERIC FRACTURE; GLOMERULUS FILTRATION RATE; HEMOGLOBIN BLOOD LEVEL; HIP ARTHROPLASTY; HIP FRACTURE; HUMAN; KIDNEY FAILURE; LOCKING SCREW; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MORTALITY RATE; OVERALL SURVIVAL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TELOPEPTIDE BLOOD LEVEL; TOTAL HIP PROSTHESIS; UREA BLOOD LEVEL; VERY ELDERLY; BLOOD; CAUSE OF DEATH; COMPLICATION; MORTALITY; PHYSIOLOGY; RENAL INSUFFICIENCY; SURVIVAL ANALYSIS;

AGED; AGED, 80 AND OVER; AGING; CAUSE OF DEATH; COLLAGEN TYPE I; FEMALE; GLOMERULAR FILTRATION RATE; HIP FRACTURES; HUMANS; MALE; RENAL INSUFFICIENCY; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 84953364599     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-015-0070-x     Document Type: Article

References (44)

1. Kannus P, Parkkari J, Sievänen H, Heinonen A, Vuori I, Järvinen M (1996) Epidemiology of hip fractures. Bone 18:57S–63S
2. Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C (2009) Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int 10:1633–1650. doi:10.1007/s00198-009-0920-3
3. Zuckerman JD (1996) Hip fracture. N Engl J Med 334:1519–1525
4. Hu F, Jiang C, Shen J, Tang P, Wang Y (2012) Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 43:676–685
5. Haentjens P, Magaziner J, Colón-Emeric CS et al (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380–390
6. Karagiannis A, Papakitsou E, Dretakis K, Galanos A, Megas P, Lambiris E, Lyritis P (2006) Mortality rates of patients with a hip fracture in a southwestern district of Greece: ten-year follow-up with reference to the type of fracture. Calcif Tissue Int 78:72–77
7. Lu-Yao GL, Baron JA, Barrett JA, Fisher ES (1994) Treatment and survival among elderly Americans with hip fractures: a population-based study. Am J Public Health 84:1287–1291
8. Fox KM, Magaziner J, Hebel JR, Kenzora JE, Kashner TM (1999) Intertrochanteric versus femoral neck hip fractures: differential characteristics, treatment, and sequelae. J Gerontol A Biol Sci Med Sci 54:635–640
9. Diamantopoulos AP, Hoff M, Hochberg M, Haugeberg G (2013) Predictors of short- and long-term mortality in males and females with hip fracture—a prospective observational cohort study. PLoS ONE 8:e78169
10. Meyer HE, Tverdal A, Falch JA, Pedersen JI (2000) Factors associated with mortality after hip fracture. Osteoporos Int 11:228–232
11. Li SG, Sun TS, Liu Z, Ren JX, Liu B, Gao Y (2013) Factors influencing postoperative mortality one year after surgery for hip fracture in Chinese elderly population. Chin Med J (Engl) 126:2715–2719
12. Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB (2009) Incidence and mortality of hip fractures in the United States. JAMA 302:1573–1579
13. Jiang HX, Majumdar SR, Dick DA, Moreau M, Raso J, Otto DD, Johnston DW (2005) Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures. J Bone Miner Res 20:494–500
14. Kannegaard PN, van der Mark S, Eiken P, Abrahamsen B (2010) Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing 39:203–209
15. Forsen L, Sogaard AJ, Meyer HE, Edna T, Kopjar B (1999) Survival after hip fracture: short- and longterm excess mortality according to age and gender. Osteoporos Int 10:73–78
16. Piirtola M, Vahlberg T, Löppönen M, Räihä I, Isoaho R, Kivelä SL (2008) Fractures as predictors of excess mortality in the aged-a population-based study with a 12-year follow-up. Eur J Epidemiol 23:747–755
17. Miyanishi K, Jingushi S, Torisu T (2010) Mortality after hip fracture in Japan: the role of nutritional status. J Orthop Surg (Hong Kong) 18:265–270
18. Meyer HE, Tverdal A, Falch JA (1995) Body height, body mass index, and fatal hip fractures: 16 years’ follow-up of 674,000 Norwegian women and men. Epidemiology 6:299–305
19. Simunovic N, Devereaux PJ, Sprague S, Guyatt GH, Schemitsch E, Debeer J, Bhandari M (2010) Effect of early surgery after hip fracture on mortality and complications: systematic review and metaanalysis. CMAJ 182:1609–1616
20. Ho CA, Li CY, Hsieh KS, Chen HF (2010) Factors determining the 1-year survival after operated hip fracture: a hospital-based analysis. J Orthop Sci 15:30–37
21. Gruson KI, Aharonoff GB, Egol KA, Zuckerman JD, Koval KJ (2002) The relationship between admission hemoglobin level and outcome after hip fracture. J Orthop Trauma 16:39–44
22. Bhaskar D, Parker MJ (2011) Haematological indices as surrogate markers of factors affecting mortality after hip fracture. Injury 42:178–182
23. Oztürk A, Ozkan Y, Akgöz S, Yalçýn N, Ozdemir RM, Aykut S (2010) The risk factors for mortality in elderly patients with hip fractures: postoperative one-year results. Singapore Med J 51:137–143
24. O’Daly BJ, Walsh JC, Quinlan JF, Falk GA, Stapleton R, Quinlan WR, O’Rourke SK (2010) Serum albumin and total lymphocyte count as predictors of outcome in hip fractures. Clin Nutr 29:89–93
25. Koval KJ, Maurer SG, Su ET, Aharonoff GB, Zuckerman JD (1999) The effects of nutritional status on outcome after hip fracture. J Orthop Trauma 13:164–169
26. Pimlott BJ, Jones CA, Beaupre LA, Johnston DW, Majumdar SR (2011) Prognostic impact of preoperative albumin on short-term mortality and complications in patients with hip fracture. Arch Gerontol Geriatr 53:90–94
27. Chakraborty B, Vishnoi G, Goswami B, Gowda SH, Chowdhury D, Agarwal S (2013) Lipoprotein(a), ferritin, and albumin in acute phase reaction predicts severity and mortality of acute ischemic stroke in North Indian Patients. J Stroke Cerebrovasc Dis 22:e159–e167
28. Hannan JL, Radwany SM, Albanese T (2012) In-hospital mortality in patients older than 60 years with every low albumin levels. J Pain Symptom Manage 43:631–637
29. Aguayo-Becerra OA, Torres-Garibay C, Macías-Amezcua MD, Fuentes-Orozco C, Chávez-Tostado Mde G, Andalón-Dueñas E, Espinosa Partida A, Alvarez-Villaseñor Adel S, Cortés-Flores AO, González- Ojeda A (2013) Serum albumin level as a risk factor for mortality in burn patients. Clinics (Sao Paulo) 68:940–945
30. Mosfeldt M, Pedersen OB, Riis T, Worm HO, Sv Mark, Jørgensen HL, Duus BR, Lauritzen JB (2012) Value of routine blood tests for prediction of mortality risk in hip fracture patients. Acta Orthop 83:31–35
31. Bombaci H, Erdoğan Ö, Çetinkaya F, Kuyumcu M, Kaya E, Bombaci E (2012) Preoperative indicators affecting postoperative mortality in elderly patients with hip fractures. Acta Orthop Traumatol Turc 46:425–429
32. Zhao J, Xia W, Nie M, Zheng X, Wang Q, Wang X, Wang W, Ning Z, Huang W, Jiang Y, Li M, Wang O, Xing X, Sun Y, Luo L, He S, Yu W, Lin Q, Pei Y, Zhang F, Han Y, Tong Y, Che Y, Shen R, Hu Y, Zhou X, Xu L (2011) The levels of bone turnover markers in Chinese postmenopausal women: peking Vertebral Fracture study. Menopause 18:1237–1243
33. Lou H, Peng C, Chen Q (2012) Clinical value ofP1NP, β-CTX and 25(OH)D3 detection in evaluating risks of fragile hip fracture in elderly patients with osteoporosis [Article in Chinese]]. Nan Fang Yi Ke Da Xue Xue Bao 32:1346–1349
34. Ivaska KK, Gerdhem P, Akesson K, Garnero P, Obrant KJ (2007) Effect of fracture on bone turnover markers: a longitudinal study comparing marker levels before and after injury in 113 elderly women. J Bone Miner Res 22:1155–1164
35. Szulc P, Maurice C, Marchand F, Delmas PD (2009) Increased bone resorption is associated with higher mortality in community-dwelling men > or = 50 years of age: the MINOS study. J Bone Miner Res 24:1116–1124
36. Sambrook PN, Chen CJ, March L, Cameron ID, Cumming RG, Lord SR, Simpson JM, Seibel MJ (2006) High bone turnover is an independent predictor of mortality in the frail elderly. J Bone Miner Res 21:549–555
37. Lerchbaum E, Schwetz V, Pilz S, Grammer TB, Look M, Boehm BO, Obermayer-Pietsch B, März W (2013) Association of bone turnover markers with mortality in men referred to coronary angiography. Osteoporos Int 24:1321–1332
38. Lyles KW, Colón-Emeric CS, Magaziner JS, HORIZON Recurrent Fracture Trial et al (2007) Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 357:1799–1809
39. Beaupre LA, Morrish DW, Hanley DA, Maksymowych WP, Bell NR, Juby AG, Majumdar SR (2011) Oral bisphosphonates are associated with reduced mortality after hip fracture. Osteoporos Int 22:983–991
40. Panula J, Pihlajamäki H, Mattila VM, Jaatinen P, Vahlberg T, Aarnio P, Kivelä SL (2011) Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord 12:105
41. Hasegawa Y, Suzuki S, Wingstrand H (2007) Risk of mortality following hip fracture in Japan. J Orthop Sci 12:113–117
42. Khan MA, Hossain FS, Ahmed I, Muthukumar N, Mohsen A (2013) Predictors of early mortality after hip fracture surgery. Int Orthop 37:2119–2124
43. Wu C, Kato TS, Pronschinske K, Qiu S, Naka Y, Takayama H, Schulze-Späte U, Cremers S, Shane E, Mancini D, Schulze PC (2012) Dynamics of bone turnover markers in patients with heart failure and following haemodynamic improvement through ventricular assist device implantation. Eur J Heart Fail 14:1356–1365
44. Seibel MJ (2005) Biochemical markers of bone turnover: part I: biochemistry and variability. Clin Biochem Rev. 26:97–122