Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria

Journal of Medicinal Chemistry

Volumn 58, Issue 24, 2015, Pages 9779-9785

  Cochrane, Stephen A ^a   Li, Xuefeng ^b   He, Sisi ^b   Yu, Min ^b   Wu, Min ^b   Vederas, John C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; ERYTHROMYCIN PLUS TRIDECAPTIN A1; POLYPEPTIDE ANTIBIOTIC AGENT; RIFAMPICIN; RIFAMPICIN PLUS TRIDECAPTIN A1; TRIDECAPTIN A1; TRIDECAPTIN A1 PLUS VANCOMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; PEPTIDE; TRIDECAPTINS;

ACINETOBACTER BAUMANNII; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS; SURVIVAL RATE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; DRUG POTENTIATION; KLEBSIELLA INFECTIONS; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ACINETOBACTER BAUMANNII; ANIMALS; ANTI-BACTERIAL AGENTS; DRUG SYNERGISM; ERYTHROMYCIN; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; PEPTIDES; RIFAMPIN; VANCOMYCIN;

EID: 84953338655     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01578     Document Type: Article

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