Late cornified envelope (LCE) proteins: Distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia

British Journal of Dermatology

Volumn 174, Issue 4, 2016, Pages 795-802

  Niehues, H ^a   Van Vlijmen Willems, I M J J ^a   Bergboer, J G M ^b   Kersten, F F J ^a   Narita, M ^c   Hendriks, W J A J ^a   Van Den Bogaard, E H ^a   Zeeuwen, P L J M ^a   Schalkwijk, J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 10; FILAGGRIN; LATE CORNIFIED ENVELOPE 3B PROTEIN; LATE CORNIFIED ENVELOPE 3C PROTEIN; LORICRIN; PROTEIN; UNCLASSIFIED DRUG; CORNIFIED ENVELOPE LIKE PROLINE RICH PROTEIN;

ARTICLE; ATOPIC DERMATITIS; CELL DIFFERENTIATION; EPIDERMIS; EPITHELIUM; GENE EXPRESSION; GRANULAR CELL; HUMAN; HUMAN TISSUE; ICHTHYOSIS VULGARIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MORPHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PSORIASIS; SKIN BIOPSY; STRATUM CORNEUM; VERRUCA VULGARIS; ADOLESCENT; ADULT; AGED; BIOLOGICAL MODEL; CELL CULTURE; METABOLISM; MIDDLE AGED; MOUTH MUCOSA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CELLS, CULTURED; CORNIFIED ENVELOPE PROLINE-RICH PROTEINS; EPIDERMIS; HUMANS; KERATINOCYTES; MIDDLE AGED; MODELS, BIOLOGICAL; MOUTH MUCOSA; PSORIASIS; YOUNG ADULT;

EID: 84953285802     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.14284     Document Type: Article

References (34)

1. Bergboer JG, Zeeuwen PL, Schalkwijk J,. Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation. J Invest Dermatol 2012; 132: 2320-31.
2. Kezic S, Novak N, Jakasa I, et al,. Skin barrier in atopic dermatitis. Front Biosci (Landmark Ed) 2014; 19: 542-56.
3. Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al,. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441-6.
4. de Cid R, Riveira-Munoz E, Zeeuwen PL, et al,. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet 2009; 41: 211-15.
5. Huffmeier U, Bergboer JG, Becker T, et al,. Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. J Invest Dermatol 2010; 130: 979-84.
6. Riveira-Munoz E, He SM, Escaramis G, et al,. Meta-analysis confirms the LCE3C-LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J Invest Dermatol 2011; 131: 1105-9.
7. Zhang XJ, Huang W, Yang S, et al,. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 2009; 41: 205-10.
8. Kezic S, Kemperman PM, Koster ES, et al,. Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol 2008; 128: 2117-19.
9. Angelova-Fischer I, Mannheimer AC, Hinder A, et al,. Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling. Exp Dermatol 2011; 20: 351-6.
10. Pendaries V, Malaisse J, Pellerin L, et al,. Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiation. J Invest Dermatol 2014; 134: 2938-46.
11. Elias PM, Gruber R, Crumrine D, et al,. Formation and functions of the corneocyte lipid envelope (CLE). Biochim Biophys Acta 2014; 1841: 314-18.
12. Bergboer JG, Tjabringa GS, Kamsteeg M, et al,. Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups. Am J Pathol 2011; 178: 1470-7.
13. Jackson B, Tilli CM, Hardman MJ, et al,. Late cornified envelope family in differentiating epithelia-response to calcium and ultraviolet irradiation. J Invest Dermatol 2005; 124: 1062-70.
14. Jackson B, Brown SJ, Avilion AA, et al,. TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J Cell Sci 2011; 124: 1681-90.
15. Tjabringa G, Bergers M, van Rens D, et al,. Development and validation of human psoriatic skin equivalents. Am J Pathol 2008; 173: 815-23.
16. Van Ruissen F, de Jongh GJ, Zeeuwen PL, et al,. Induction of normal and psoriatic phenotypes in submerged keratinocyte cultures. J Cell Physiol 1996; 168: 442-52.
17. Jansen PA, Kamsteeg M, Rodijk-Olthuis D, et al,. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. J Invest Dermatol 2009; 129: 2167-74.
18. de Koning HD, Kamsteeg M, Rodijk-Olthuis D, et al,. Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients. J Invest Dermatol 2011; 131: 263-6.
19. Alkemade JA, Molhuizen HO, Ponec M, et al,. SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes. J Cell Sci 1994; 107: 2335-42.
20. Molhuizen HO, Schalkwijk J,. Structural, biochemical, and cell biological aspects of the serine proteinase inhibitor SKALP/elafin/ESI. Biol Chem Hoppe Seyler 1995; 376: 1-7.
21. Wingens M, van Bergen BH, Hiemstra PS, et al,. Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J Invest Dermatol 1998; 111: 996-1002.
22. Jansen PA, Rodijk-Olthuis D, Hollox EJ, et al,. Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS ONE 2009; 4: e4725.
23. Besgen P, Trommler P, Vollmer S, Prinz JC,. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. J Immunol 2010; 184: 5392-402.
24. Yamada KM, Hall A,. Reproducibility and cell biology. J Cell Biol 2015; 209: 191-3.
25. Prinz F, Schlange T, Asadullah K,. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 2011; 10: 712.
26. Baker M,. Reproducibility crisis: blame it on the antibodies. Nature 2015; 521: 274-6.
27. Sakabe J, Kamiya K, Yamaguchi H, et al,. Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer. J Allergy Clin Immunol 2014; 134: 957-60.e8.
28. Steinert PM, Marekov LN,. Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. J Biol Chem 1997; 272: 2021-30.
29. Rice RH, Bradshaw KM, Durbin-Johnson BP, et al,. Distinguishing ichthyoses by protein profiling. PLoS ONE 2013; 8: e75355.
30. Zeeuwen PL, Cheng T, Schalkwijk J,. The biology of cystatin M/E and its cognate target proteases. J Invest Dermatol 2009; 129: 1327-38.
31. Eckhart L, Declercq W, Ban J, et al,. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation. J Invest Dermatol 2000; 115: 1148-51.
32. Zeeuwen PL,. Epidermal differentiation: the role of proteases and their inhibitors. Eur J Cell Biol 2004; 83: 761-73.
33. List K, Currie B, Scharschmidt TC, et al,. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem 2007; 282: 36714-23.
34. de Guzman Strong C, Conlan S, Deming CB, et al,. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis. Hum Mol Genet 2010; 19: 1453-60.