Meta-analysis confirms the LCE3C-LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6

Journal of Investigative Dermatology

Volumn 131, Issue 5, 2011, Pages 1105-1109

  Riveira Munoz, Eva ^a   He, Su Min ^b,c   Escaramís, Georgia ^a   Stuart, Philip E ^d   Hüffmeier, Ulrike ^e   Lee, Catherine ^f   Kirby, Brian ^g   Oka, Akira ^h   Giardina, Emiliano ⁱ   Liao, Wilson ^j   Bergboer, Judith ^k   Kainu, Kati ^l,m   De Cid, Rafael ⁿ   Munkhbat, Batmunkh ^o   Zeeuwen, Patrick L J M ^k   Armour, John A L ^p   Poon, Annie ^j   Mabuchi, Tomotaka ^h   Ozawa, Akira ^h   Zawirska, Agnieszka ^g   Burden, A David ^q   Barker, Jonathan N ^f   Capon, Francesca ^f   Traupe, Heiko ^r   Sun, Liang Dan ^b,c   Cui, Yong ^b   Yin, Xian Yong ^b   Chen, Gang ^b   Lim, Henry W ^s   Nair, Rajan P ^d   Voorhees, John J ^d   Tejasvi, Trilokraj ^d   Pujol, Ramón ^t   Munkhtuvshin, Namid ^o   Fischer, Judith ⁿ   Kere, Juha ^l,u,v   Schalkwijk, Joost ^k   Bowcock, Anne ^w   Kwok, Pui Yan ^j   Novelli, Giuseppe ⁱ   Inoko, Hidetoshi ^h   Ryan, Anthony W ^g   Trembath, Richard C ^f   Reis, André ^e   Zhang, Xue Jun ^b,c   Elder, James T ^d,x   Estivill, Xavier ^a   more..

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g ST JAMES S HOSPITAL   (Ireland)

^h TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁱ TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^l UNIVERSITY OF HELSINKI   (Finland)

^m HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

ⁿ CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^o Institute of Veterinary Medicine   (Mongolia)

^p UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^q WESTERN INFIRMARY   (United Kingdom)

^r INST OF REPRO MED OF THE UNIV   (Germany)

^s HENRY FORD HOSPITAL   (United States)

^t HOSPITAL DEL MAR   (Spain)

^u KAROLINSKA INSTITUTE   (Sweden)

^v FOLKHÄLSAN INSTITUTE OF GENETICS   (Finland)

^w WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^x VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HLA C ANTIGEN;

ARTICLE; CHINA; CHINESE; CONTROLLED STUDY; ETHNIC GROUP; FINLAND; FRANCE; GENE; GENE DELETION; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC EPISTASIS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GERMANY; HLA SYSTEM; HUMAN; IMMUNE SYSTEM; IRELAND; ITALY; JAPAN; LCE3B GENE; LCE3C GENE; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MONGOLIA; NETHERLANDS; PRIORITY JOURNAL; PSORIASIS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; UNITED KINGDOM; UNITED STATES;

EID: 79953129971     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.350     Document Type: Article

References (15)

1. Asumalahti K, Veal C, Laitinen T et al. (2002) Coding haplotype analysis supports HCRas the putativesusceptibility genefor psoriasis atthe MHC PSORS1 locus. Hum Mol Genet 11:589-97 (Pubitemid 34257495)
2. Bergboer JG, Zeeuwen PL, Irvine AD et al. (2010) Deletion of late cornified envelope 3B and 3C genes is not associated with atopic dermatitis. J Invest Dermatol 130:2057-61
3. Bowcock AM (2005) The genetics of psoriasis and autoimmunity. Annu Rev Genomics Hum Genet 6:93-122 (Pubitemid 41397077)
4. Bowes J, Flynn E, Ho P et al. (2010) Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. Ann Rheum Dis; e-pub ahead of print 21 September 2010
5. Coto E, Santos-Juanes J, Coto-Segura P et al. (2010) Mutation analysis of the LCE3B/LCE3C genes in psoriasis. BMC Med Genet 11:45
6. de Cid R, Riveira-Munoz E, Zeeuwen PL et al. (2009) Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet 41:211-5
7. Docampo E, Rabionet R, Riveira-Muñoz E et al. (2010) Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis. Arthritis Rheum 62:1246-51
8. Fan X, Yang S, Huang W et al. (2008) Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population. PLoS Genet 4:e1000038
9. Hüffmeier U, Bergboer JG, Becker T et al. (2010a) Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. J Invest Dermatol 130:979-84
10. Hüffmeier U, Estivill X, Riveira-Munoz E et al. (2010b) Deletion of LCE3Cand LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients. Ann Rheum Dis 69:876-8
11. Ioannidis JP, Patsopoulos NA, Evangelou E (2007) Heterogeneity in meta-analyses of genome-wide association investigations. PLoS ONE 9:e841
12. Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Inter Med 9:820-6 (Pubitemid 27465551)
13. Nair RP, Stuart P, Nistor I et al. (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet 78:827-51
14. Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361:496-509
15. Zhang XJ, Huang W, Yang S et al. (2009) Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 41:205-10