Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines

International Journal of Oncology

Volumn 48, Issue 1, 2016, Pages 67-72

  He, Ningning ^a   Kim, Nayoung ^a   Jeong, Euna ^a   Lu, Yiling ^b   Mills, Gordon B ^b   Yoon, Sukjoon ^a  

^a Sookmyung Women's University   (South Korea)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Cancer cell line panel; Glucose starvation; Mutation; Reverse phase protein array

Indexed keywords

GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOPROTEIN; PROTEIN ANTIBODY; TUMOR PROTEIN;

ARTICLE; CANCER CELL LINE; LUNG CANCER CELL LINE; MUTATION; NEOPLASM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; BIOSYNTHESIS; CELL LINEAGE; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL LINEAGE; GLUCOSE; HUMANS; MUTATION; NEOPLASM PROTEINS; NEOPLASMS; PROTEIN ARRAY ANALYSIS;

EID: 84953243014     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.3242     Document Type: Article

References (20)

1. Tibes R, Qiu Y, Lu Y, Hennessy B, Andreeff M, Mills GB and Kornblau SM: Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol Cancer Ther 5: 2512-2521, 2006.
2. Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G and Sorger P: Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene 32: 3470-3476, 2013.
3. Nishizuka S, Charboneau L, Young L, Major S, Reinhold WC, Waltham M, Kouros-Mehr H, Bussey KJ, Lee JK, Espina V, et al: Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proc Natl Acad Sci USA 100: 14229-14234, 2003.
4. Boyd ZS, Wu QJ, O'Brien C, Spoerke J, Savage H, Fielder PJ, Amler L, Yan Y and Lackner MR: Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays. Mol Cancer Ther 7: 3695-3706, 2008.
5. He L, Li X, Luo HS, Rong H and Cai J: Possible mechanism for the regulation of glucose on proliferation, inhibition and apoptosis of colon cancer cells induced by sodium butyrate. World J Gastroenterol 13: 4015-4018, 2007.
6. Elf SE and Chen J: Targeting glucose metabolism in patients with cancer. Cancer 120: 774-780, 2014.
7. Lee AS: Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer 14: 263-276, 2014.
8. Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, et al: Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set. Mol Cancer Ther 9: 257-267, 2010.
9. Xu H, Baroukh C, Dannenfelser R, Chen EY, Tan CM, Kou Y, Kim YE, Lemischka IR and Ma'ayan A: ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells. Database (Oxford) 2013: bat045, 2013.
10. Kim N, Park H, He N, Lee HY and Yoon S: QCanvas: an advanced tool for data clustering and visualization of genomics data. Genomics Inform 10: 263-265, 2012.
11. Saltiel AR and Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806, 2001.
12. Priebe A, Tan L, Wahl H, Kueck A, He G, Kwok R, Opipari A and Liu JR: Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells. Gynecol Oncol 122: 389-395, 2011.
13. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, et al: Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem 286: 5921-5933, 2011.
14. Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB and Ding Z: Site-specific activation of AKT protects cells from death induced by glucose deprivation. Oncogene 33: 745-755, 2014.
15. Taubes G: Cancer research. Ravenous for glucose. Science 335: 31, 2012.
16. Adekola K, Rosen ST and Shanmugam M: Glucose transporters in cancer metabolism. Curr Opin Oncol 24: 650-654, 2012.
17. Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899, 2004.
18. Neary CL and Pastorino JG: Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells. J Cell Physiol 228: 1943-1948, 2013.
19. Kim N, He N, Kim C, Zhang F, Lu Y, Yu Q, Stemke-Hale K, Greshock J, Wooster R, Yoon S, et al: Systematic analysis of genotype-specific drug responses in cancer. Int J Cancer 131: 2456-2464, 2012.
20. He N, Kim N, Song M, Park C, Kim S, Park EY, Yim HY, Kim K, Park JH, Kim KI, et al: Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1 driven regulation of cAMP phosphodiesterase-4D. Mol Cancer Ther 13: 2463-2473, 2014.