Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

PLoS Pathogens

Volumn 11, Issue 12, 2015, Pages

  Gulati, Sunita ^a   Schoenhofen, Ian C ^b   Whitfield, Dennis M ^b   Cox, Andrew D ^b   Li, Jianjun ^f   St Michael, Frank ^b   Vinogradov, Evgeny V ^b   Stupak, Jacek ^b   Zheng, Bo ^a   Ohnishi, Makoto ^c   Unemo, Magnus ^d   Lewis, Lisa A ^a   Taylor, Rachel E ^e   Landig, Corinna S ^e   Diaz, Sandra ^e   Reed, George W ^a   Varki, Ajit ^e   Rice, Peter A ^a   Ram, Sanjay ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; COMPLEMENT FACTOR H; CYTIDINE PHOSPHATE; CYTIDINE PHOSPHATE LEG5AC7AC; ESTRADIOL; LEGIONAMINIC ACID; LIPOOLIGOSACCHARIDE; N ACETYLNEURAMINIC ACID; NEU5AC9AC; NEU5AC9AZ; NEU5GC; NEU5GC8ME; PSEUDAMINIC ACID; SIALIC ACID; UNCLASSIFIED DRUG; COMPLEMENT; CYTIDINE PHOSPHATE N ACETYLNEURAMINIC ACID; CYTIDINE-5'-MONOPHOSPHOSIALIC ACID; LIPID-LINKED OLIGOSACCHARIDES; LIPOPOLYSACCHARIDE; SIALIC ACID DERIVATIVE;

ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; DISEASE CLEARANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GONORRHEA; HUMAN; MASS SPECTROMETRY; MOUSE; NEISSERIA GONORRHOEAE; NONHUMAN; PATHOGEN LOAD; SERUM BACTERICIDAL ANTIBODY ASSAY; SYNTHESIS; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; IMMUNOLOGY; METABOLISM; MULTIDRUG RESISTANCE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; COMPLEMENT SYSTEM PROTEINS; CYTIDINE MONOPHOSPHATE; CYTIDINE MONOPHOSPHATE N-ACETYLNEURAMINIC ACID; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GONORRHEA; HUMANS; LIPOPOLYSACCHARIDES; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; NEISSERIA GONORRHOEAE; SIALIC ACIDS;

EID: 84953237996     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005290     Document Type: Article

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