Traditional serrated adenoma (TSA): Morphological questions, queries and quandaries

Journal of Clinical Pathology

Volumn 69, Issue 1, 2016, Pages 6-11

  Chetty, Runjan ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; BIOPSY; CLASSIFICATION; COLON POLYP; COLORECTAL TUMOR; DIFFERENTIAL DIAGNOSIS; HUMAN; MULTIPLE CANCER; NOMENCLATURE; PATHOLOGY; PREDICTIVE VALUE; PROGNOSIS;

ADENOMATOUS POLYPS; BIOPSY; COLONIC POLYPS; COLORECTAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; HUMANS; NEOPLASMS, MULTIPLE PRIMARY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TERMINOLOGY AS TOPIC;

EID: 84953203867     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2015-203452     Document Type: Review

References (14)

1. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14:524-37.
2. Wiland HO IV, Shadrach B, Allende D, et al. Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum. Am J Surg Pathol 2014;38:1290-7.
3. Kim M-J, Lee E-J, Chun S-M, et al. The significance of ectopic crypt formation in the differential diagnosis of colorectal polyps. Diagn Pathol 2014;9:212.
4. Bettington ML, Walker NI, Rosty C, et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Mod Pathol 2015;28:414-27.
5. Hafezi-Bakhtiari S, Wang LM, Colling R, et al. Histological overlap between colorectal villous/tubulovillous and traditional serrated adenomas. Histopathology 2015;66:308-13.
6. Yantiss RK, Oh KY, Chen Y-T, et al. Filiform serrated adenomas: A clinicopathologic and immunophenotypic study of cases. Am J Surg Pathol 2007;31:1238-45.
7. Ha SY, Lee S-M, Lee EJ, et al. Filiform serrated adenoma is an unusual, less aggressive variant of traditional serrated adenoma. Pathology 2012;44:18-23.
8. Tsai J-H, Liau J-Y, Lin Y-L, et al. Traditional serrated adenoma has two pathways of neoplastic progression that are distinct from the sessile serrated pathway of colorectal carcinogenesis. Mod Pathol 2014;27:1375-85.
9. Lazarus R, Junttila OE, Karttunen TJ, et al. The risk of metachronous neoplasia in patients with serrated adenoma. Am J Clin Pathol 2005;123:349-59.
10. Goldstein NS. Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens. Am J Clin Pathol 2006;125:132-45.
11. Torlakovic EE, Gomez JD, Driman DK, et al. Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol 2008;32:21-9.
12. Chetty R, Hafezi-Bakhtiari S, Serra S, et al. Traditional serrated adenomas (TSAs) admixed with other serrated (so-called precursor) polyps and conventional adenomas: A frequent occurrence. J Clin Pathol 2015;68:270-3.
13. Kim M-J, Lee E-J, Suh J-P, et al. Traditional serrated adenoma of the colorectum: Clinicopathologic implications and endoscopic findings of the precursor lesions. Am J Clin Pathol 2013;140:898-911.
14. Bettington ML, Walker N, Rosty C, et al. Serrated tubulovillous adenoma of the large intestine. Histopathology 2015 Jul 25. doi: 10.1111/his.12788.