Novel phenylalanine derived diamides as Factor XIa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 2, 2016, Pages 472-478

  Smith, Leon M ^a   Orwat, Michael J ^a   Hu, Zilun ^a   Han, Wei ^a   Wang, Cailan ^a   Rossi, Karen A ^a   Gilligan, Paul J ^a   Pabbisetty, Kumar B ^a   Osuna, Honey ^a   Corte, James R ^a   Rendina, Alan R ^a   Luettgen, Joseph M ^a   Wong, Pancras C ^a   Narayanan, Ranga ^a   Harper, Timothy W ^a   Bozarth, Jeffrey M ^a   Crain, Earl J ^a   Wei, Anzhi ^a   Ramamurthy, Vidhyashankar ^a   Morin, Paul E ^a   Xin, Baomin ^a   Zheng, Joanna ^a   Seiffert, Dietmar A ^a   Quan, Mimi L ^a   Lam, Patrick Y S ^a   Wexler, Ruth R ^a   Pinto, Donald J P ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Anticoagulant; aPTT; Factor XIa; FXIa; Serine protease; Thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 11A INHIBITOR; DIAMIDE; PHENYLALANINE DERIVATIVE; ANILIDE; PHENYLALANINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CAROTID ARTERY THROMBOSIS; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; HUMAN; HYDROGEN BOND; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DOG; RABBITS AND HARES; SYNTHESIS;

ANILIDES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOGS; FACTOR XIA; PHENYLALANINE; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84952986270     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.11.089     Document Type: Article

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