-
1
-
-
84952985022
-
Omega-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
-
(Bayer Healthcare LLC). US 2002042517
-
Scott, W.J., Joel, R., Ridel, B. et al. (Bayer Healthcare LLC). omega-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors. US 2002042517.
-
-
-
Scott, W.J.1
Joel, R.2
Ridel, B.3
-
2
-
-
84952976744
-
Diaryl ureas with kinase inhibiting activity
-
Bayer Pharmaceuticals Corp. CA 2526617, EP 1636585, JP 200751103, US 2007020704, WO 2004113274
-
Dumas, J., Lynch, M., Scott, W.J., Ladouceur, G., Wilhelm, S. (Bayer Pharmaceuticals Corp.). Diaryl ureas with kinase inhibiting activity. CA 2526617, EP 1636585, JP 200751103, US 2007020704, WO 2004113274.
-
-
-
Dumas, J.1
Lynch, M.2
Scott, W.J.3
Ladouceur, G.4
Wilhelm, S.5
-
3
-
-
79955477820
-
Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
-
(Bayer Pharmaceuticals Corp). EP 1663978, JP 2006528196, US 2005038080, WO 2005009961
-
Dumas, J., Wilhelm, S., Boyer, S., Riedl, B. (Bayer Pharmaceuticals Corp). Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions. EP 1663978, JP 2006528196, US 2005038080, WO 2005009961.
-
-
-
Dumas, J.1
Wilhelm, S.2
Boyer, S.3
Riedl, B.4
-
4
-
-
0036795899
-
Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
-
Dagher, R., Cohen, M., Williams, G. et al. Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin Cancer Res 2002, 8(10): 3034-8. (Pubitemid 35155011)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.10
, pp. 3034-3038
-
-
Dagher, R.1
Cohen, M.2
Williams, G.3
Rothmann, M.4
Gobburu, J.5
Robbie, G.6
Rahman, A.7
Chen, G.8
Staten, A.9
Griebel, D.10
Pazdur, R.11
-
5
-
-
69949151386
-
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
-
Jänne, P.A., Gray, N., Settleman, J. Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov 2009, 8(9): 709-23.
-
(2009)
Nat Rev Drug Discov
, vol.8
, Issue.9
, pp. 709-723
-
-
Jänne, P.A.1
Gray, N.2
Settleman, J.3
-
6
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
Wilhelm, S.M., Carter, C., Tang, L. et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64(19): 7099-109. (Pubitemid 39331023)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
7
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet, J.M., Ricci, S., Mazzaferro, V. et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359(4): 378-90.
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
8
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier, B., Eisen, T., Stadler, W.M. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356(2): 125-34. (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
9
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal, and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
Epub ahead of print
-
Wilhelm, S.M., Dumas, J., Adnane, L. et al. Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal, and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 2010, Epub ahead of print.
-
(2010)
Int J Cancer
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
-
10
-
-
34248583886
-
MAP kinase signalling pathways in cancer
-
DOI 10.1038/sj.onc.1210421, PII 1210421
-
Dhillon, A.S., Hagan, S., Rath, O. et al. MAP kinase signalling pathways in cancer. Oncogene 2007, 26(22): 3279-90. (Pubitemid 46763021)
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
Kolch, W.4
-
11
-
-
70449647041
-
Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): Focus on sorafenib and sunitinib
-
Lipworth, A.D., Robert, C., Zhu, A.X. Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): Focus on sorafenib and sunitinib. Oncology 2009, 77(5): 257-71.
-
(2009)
Oncology
, vol.77
, Issue.5
, pp. 257-271
-
-
Lipworth, A.D.1
Robert, C.2
Zhu, A.X.3
-
12
-
-
65549122619
-
Management of hypertension in angiogenesis inhibitor-treated patients
-
Izzedine, H., Ederhy, S., Goldwasser, F. et al. Management of hypertension in angiogenesis inhibitor-treated patients. Ann Oncol 2009, 20(5): 807-15.
-
(2009)
Ann Oncol
, vol.20
, Issue.5
, pp. 807-815
-
-
Izzedine, H.1
Ederhy, S.2
Goldwasser, F.3
-
13
-
-
63049088767
-
Renal effects of anti-angiogenesis therapy: Update for the internist
-
Gurevich, F., Perazella, M.A. Renal effects of anti-angiogenesis therapy: Update for the internist. Am J Med 2009, 122(4): 322-8.
-
(2009)
Am J Med
, vol.122
, Issue.4
, pp. 322-328
-
-
Gurevich, F.1
Perazella, M.A.2
-
14
-
-
72449132908
-
VECF signalling inhibition-induced proteinuria: Mechanisms, significance and management
-
Izzedine, H., Massard, C., Spano, J.P. et al. VECF signalling inhibition-induced proteinuria: Mechanisms, significance and management. Eur J Cancer 2010, 46(2): 439-48.
-
(2010)
Eur J Cancer
, vol.46
, Issue.2
, pp. 439-448
-
-
Izzedine, H.1
Massard, C.2
Spano, J.P.3
-
15
-
-
67650173972
-
Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy
-
Torino, F., Corsello, S.M., Longo, R. et al. Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy. Nat Rev Clin Oncol 2009, 6(4): 219-28.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, Issue.4
, pp. 219-228
-
-
Torino, F.1
Corsello, S.M.2
Longo, R.3
-
16
-
-
78650783946
-
Experience with sorafenib and adverse event management
-
Epub ahead of print
-
Bellmunt, J., Eisen, T., Fishman, M., Quinn, D. Experience with sorafenib and adverse event management. Crit Rev Oncol Hematol 2010, Epub ahead of print.
-
(2010)
Crit Rev Oncol Hematol
-
-
Bellmunt, J.1
Eisen, T.2
Fishman, M.3
Quinn, D.4
-
17
-
-
78650325328
-
Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors: Final results of a dose-escalation study
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] Abst 2558
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 2558.
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Frost, A.1
Buechert, M.2
Unger, C.3
-
18
-
-
79956059060
-
Phase I study of BAY 73-4506, a multikinase inhibitor, administered for 21 days on/7 days off in patients with advanced solid tumors
-
rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] Abst 3593
-
rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.): Abst 3593.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Hedbom, S.1
Steinbild, S.2
Frost, A.3
-
19
-
-
73349096056
-
Phase II study of BAY 73-4506, a multikinase inhibitor, in previously untreated patients with metastatic or unresectable renal cell cancer
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] Abst 5033
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] 2009, 27(15, Suppl.): Abst 5033.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Eisen, T.1
Joensuu, H.2
Nathan, P.3
-
20
-
-
77950639677
-
Phase II trial of the oral multikinase inhibitor BAY 73-4506 as 1st-line therapy in patients with metastatic or unresectable renal cell cancer (RCC)
-
th ECCO and 34th ESMO (Sept 20-24, Berlin) 2009] Abst O-7105
-
th ECCO and 34th ESMO (Sept 20-24, Berlin) 2009] 2009, 7(2): Abst O-7105.
-
(2009)
Eur J Cancer Suppl
, vol.7
, Issue.2
-
-
Eisen, T.1
Joensuu, H.2
Nathan, P.3
-
21
-
-
79956036764
-
Identification of plasma biomarkers for the multikinase inhibitor regorafenib (BAY 73-4506) in patients (pts) with renal cell cancer (RCC)
-
th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] Abst 123P
-
th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] 2010, 21(Suppl. 8): Abst 123P.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Jeffers, M.1
Quinn, D.I.2
Joensuu, H.3
-
22
-
-
77953911437
-
Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced refractory colorectal carcinoma (CRC)
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] Abst 3560
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] 2009, 27(15, Suppl.): Abst 3560.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Strumberg, D.1
Scheulen, M.E.2
Frost, A.3
-
23
-
-
84861041632
-
Analysis of plasma biomarkers, DCE-MRI, and KRAS mutations in patients (pts) with advanced colorectal carcinoma (CRC) treated with the multikinase inhibitor regorafenib
-
th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] Abst 619P
-
th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] 2010, 21(Suppl. 8): Abst 619P.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Christensen, O.1
Buechert, M.2
Fasol, U.3
-
24
-
-
79955984428
-
Phase I dose-escalation study of continuously administered regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] Abst 3035
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 3035.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Shimizu, T.1
Tolcher, A.W.2
Patnaik, A.3
-
25
-
-
79955816044
-
Phase I study of regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, administered continuously in patients (pts) with advanced refractory non-small cell lung cancer (NSCLC)
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] Abst 7585
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 7585.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Kies, M.S.1
Blumenschein Jr., G.R.2
Christensen, O.3
-
30
-
-
73349121966
-
Impact of anti-angiogenic treatments on metastatic renal cell carcinoma
-
Ainsworth, N.L., Lee, J.S., Eisen, T. Impact of anti-angiogenic treatments on metastatic renal cell carcinoma. Expert Rev Anticancer Ther 2009, 9(12): 1793-805.
-
(2009)
Expert Rev Anticancer Ther
, vol.9
, Issue.12
, pp. 1793-1805
-
-
Ainsworth, N.L.1
Lee, J.S.2
Eisen, T.3
-
31
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
DOI 10.1200/JCO.2003.04.190
-
Heinrich, M.C., Corless, C.L., Demetri, G.D. et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003, 21(23): 4342-9. (Pubitemid 46621810)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.23
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
Blanke, C.D.4
Von Mehren, M.5
Joensuu, H.6
McGreevey, L.S.7
Chen, C.-J.8
Van Den, A.A.D.9
Druker, B.J.10
Kiese, B.11
Eisenberg, B.12
Roberts, P.J.13
Singer, S.14
Fletcher, C.D.M.15
Silberman, S.16
Dimitrijevic, S.17
Fletcher, J.A.18
-
32
-
-
50249092801
-
Heterogeneity of kinase inhibitor resistance mechanisms in GIST
-
Liegl, B., Kepten, I., Le, C. et al. Heterogeneity of kinase inhibitor resistance mechanisms in GIST. J Pathol 2008, 216(1): 64-74.
-
(2008)
J Pathol
, vol.216
, Issue.1
, pp. 64-74
-
-
Liegl, B.1
Kepten, I.2
Le, C.3
-
33
-
-
33750595859
-
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
-
DOI 10.1200/JCO.2006.06.2265
-
Heinrich, M.C., Corless, C.L., Blanke, C.D. et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006, 24(29): 4764-74. (Pubitemid 46630941)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.29
, pp. 4764-4774
-
-
Heinrich, M.C.1
Corless, C.L.2
Blanke, C.D.3
Demetri, G.D.4
Joensuu, H.5
Roberts, P.J.6
Eisenberg, B.L.7
Von Mehren, M.8
Fletcher, C.D.M.9
Sandau, K.10
McDougall, K.11
Ou, W.-B.12
Chen, C.-J.13
Fletcher, J.A.14
-
34
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
Engelman, J.A., Zejnullahu, K., Mitsudomi, T. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316(5827): 1039-43. (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
35
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
DOI 10.1016/S0140-6736(06)69446-4, PII S0140673606694464
-
Demetri, G.D., van Oosterom, A.T., Garrett, C.R. et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 2006, 368(9544): 1329-38. (Pubitemid 44528723)
-
(2006)
Lancet
, vol.368
, Issue.9544
, pp. 1329-1338
-
-
Demetri, G.D.1
Van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Casali, P.G.17
-
36
-
-
59949103514
-
Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] Abst 10502
-
th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 10502.
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Wiebe, L.1
Kasza, K.E.2
Maki, R.G.3
|