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Volumn 36, Issue 1, 2011, Pages 17-23

Broad-spectrum kinase inhibitor oncolytic

Author keywords

[No Author keywords available]

Indexed keywords

GADOMER 17; REGORAFENIB; SORAFENIB; SUNITINIB; VASCULOTROPIN RECEPTOR 2;

EID: 84952979890     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2011.036.01.1568343     Document Type: Review
Times cited : (1)

References (38)
  • 1
    • 84952985022 scopus 로고    scopus 로고
    • Omega-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
    • (Bayer Healthcare LLC). US 2002042517
    • Scott, W.J., Joel, R., Ridel, B. et al. (Bayer Healthcare LLC). omega-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors. US 2002042517.
    • Scott, W.J.1    Joel, R.2    Ridel, B.3
  • 2
    • 84952976744 scopus 로고    scopus 로고
    • Diaryl ureas with kinase inhibiting activity
    • Bayer Pharmaceuticals Corp. CA 2526617, EP 1636585, JP 200751103, US 2007020704, WO 2004113274
    • Dumas, J., Lynch, M., Scott, W.J., Ladouceur, G., Wilhelm, S. (Bayer Pharmaceuticals Corp.). Diaryl ureas with kinase inhibiting activity. CA 2526617, EP 1636585, JP 200751103, US 2007020704, WO 2004113274.
    • Dumas, J.1    Lynch, M.2    Scott, W.J.3    Ladouceur, G.4    Wilhelm, S.5
  • 3
    • 79955477820 scopus 로고    scopus 로고
    • Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
    • (Bayer Pharmaceuticals Corp). EP 1663978, JP 2006528196, US 2005038080, WO 2005009961
    • Dumas, J., Wilhelm, S., Boyer, S., Riedl, B. (Bayer Pharmaceuticals Corp). Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions. EP 1663978, JP 2006528196, US 2005038080, WO 2005009961.
    • Dumas, J.1    Wilhelm, S.2    Boyer, S.3    Riedl, B.4
  • 5
    • 69949151386 scopus 로고    scopus 로고
    • Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
    • Jänne, P.A., Gray, N., Settleman, J. Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov 2009, 8(9): 709-23.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.9 , pp. 709-723
    • Jänne, P.A.1    Gray, N.2    Settleman, J.3
  • 7
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J.M., Ricci, S., Mazzaferro, V. et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359(4): 378-90.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 9
    • 79954499886 scopus 로고    scopus 로고
    • Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal, and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
    • Epub ahead of print
    • Wilhelm, S.M., Dumas, J., Adnane, L. et al. Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal, and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 2010, Epub ahead of print.
    • (2010) Int J Cancer
    • Wilhelm, S.M.1    Dumas, J.2    Adnane, L.3
  • 10
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • DOI 10.1038/sj.onc.1210421, PII 1210421
    • Dhillon, A.S., Hagan, S., Rath, O. et al. MAP kinase signalling pathways in cancer. Oncogene 2007, 26(22): 3279-90. (Pubitemid 46763021)
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 11
    • 70449647041 scopus 로고    scopus 로고
    • Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): Focus on sorafenib and sunitinib
    • Lipworth, A.D., Robert, C., Zhu, A.X. Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): Focus on sorafenib and sunitinib. Oncology 2009, 77(5): 257-71.
    • (2009) Oncology , vol.77 , Issue.5 , pp. 257-271
    • Lipworth, A.D.1    Robert, C.2    Zhu, A.X.3
  • 12
    • 65549122619 scopus 로고    scopus 로고
    • Management of hypertension in angiogenesis inhibitor-treated patients
    • Izzedine, H., Ederhy, S., Goldwasser, F. et al. Management of hypertension in angiogenesis inhibitor-treated patients. Ann Oncol 2009, 20(5): 807-15.
    • (2009) Ann Oncol , vol.20 , Issue.5 , pp. 807-815
    • Izzedine, H.1    Ederhy, S.2    Goldwasser, F.3
  • 13
    • 63049088767 scopus 로고    scopus 로고
    • Renal effects of anti-angiogenesis therapy: Update for the internist
    • Gurevich, F., Perazella, M.A. Renal effects of anti-angiogenesis therapy: Update for the internist. Am J Med 2009, 122(4): 322-8.
    • (2009) Am J Med , vol.122 , Issue.4 , pp. 322-328
    • Gurevich, F.1    Perazella, M.A.2
  • 14
    • 72449132908 scopus 로고    scopus 로고
    • VECF signalling inhibition-induced proteinuria: Mechanisms, significance and management
    • Izzedine, H., Massard, C., Spano, J.P. et al. VECF signalling inhibition-induced proteinuria: Mechanisms, significance and management. Eur J Cancer 2010, 46(2): 439-48.
    • (2010) Eur J Cancer , vol.46 , Issue.2 , pp. 439-448
    • Izzedine, H.1    Massard, C.2    Spano, J.P.3
  • 15
    • 67650173972 scopus 로고    scopus 로고
    • Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy
    • Torino, F., Corsello, S.M., Longo, R. et al. Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy. Nat Rev Clin Oncol 2009, 6(4): 219-28.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.4 , pp. 219-228
    • Torino, F.1    Corsello, S.M.2    Longo, R.3
  • 16
  • 17
    • 78650325328 scopus 로고    scopus 로고
    • Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors: Final results of a dose-escalation study
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] Abst 2558
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 2558.
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Frost, A.1    Buechert, M.2    Unger, C.3
  • 18
    • 79956059060 scopus 로고    scopus 로고
    • Phase I study of BAY 73-4506, a multikinase inhibitor, administered for 21 days on/7 days off in patients with advanced solid tumors
    • rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] Abst 3593
    • rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.): Abst 3593.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Hedbom, S.1    Steinbild, S.2    Frost, A.3
  • 19
    • 73349096056 scopus 로고    scopus 로고
    • Phase II study of BAY 73-4506, a multikinase inhibitor, in previously untreated patients with metastatic or unresectable renal cell cancer
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] Abst 5033
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] 2009, 27(15, Suppl.): Abst 5033.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Eisen, T.1    Joensuu, H.2    Nathan, P.3
  • 20
    • 77950639677 scopus 로고    scopus 로고
    • Phase II trial of the oral multikinase inhibitor BAY 73-4506 as 1st-line therapy in patients with metastatic or unresectable renal cell cancer (RCC)
    • th ECCO and 34th ESMO (Sept 20-24, Berlin) 2009] Abst O-7105
    • th ECCO and 34th ESMO (Sept 20-24, Berlin) 2009] 2009, 7(2): Abst O-7105.
    • (2009) Eur J Cancer Suppl , vol.7 , Issue.2
    • Eisen, T.1    Joensuu, H.2    Nathan, P.3
  • 21
    • 79956036764 scopus 로고    scopus 로고
    • Identification of plasma biomarkers for the multikinase inhibitor regorafenib (BAY 73-4506) in patients (pts) with renal cell cancer (RCC)
    • th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] Abst 123P
    • th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] 2010, 21(Suppl. 8): Abst 123P.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Jeffers, M.1    Quinn, D.I.2    Joensuu, H.3
  • 22
    • 77953911437 scopus 로고    scopus 로고
    • Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced refractory colorectal carcinoma (CRC)
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] Abst 3560
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] 2009, 27(15, Suppl.): Abst 3560.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Strumberg, D.1    Scheulen, M.E.2    Frost, A.3
  • 23
    • 84861041632 scopus 로고    scopus 로고
    • Analysis of plasma biomarkers, DCE-MRI, and KRAS mutations in patients (pts) with advanced colorectal carcinoma (CRC) treated with the multikinase inhibitor regorafenib
    • th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] Abst 619P
    • th Eur Soc Med Oncol (ESMO) Congr (Oct 8-12, Milan) 2010] 2010, 21(Suppl. 8): Abst 619P.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Christensen, O.1    Buechert, M.2    Fasol, U.3
  • 24
    • 79955984428 scopus 로고    scopus 로고
    • Phase I dose-escalation study of continuously administered regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] Abst 3035
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 3035.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Shimizu, T.1    Tolcher, A.W.2    Patnaik, A.3
  • 25
    • 79955816044 scopus 로고    scopus 로고
    • Phase I study of regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, administered continuously in patients (pts) with advanced refractory non-small cell lung cancer (NSCLC)
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] Abst 7585
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 7585.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Kies, M.S.1    Blumenschein Jr., G.R.2    Christensen, O.3
  • 30
    • 73349121966 scopus 로고    scopus 로고
    • Impact of anti-angiogenic treatments on metastatic renal cell carcinoma
    • Ainsworth, N.L., Lee, J.S., Eisen, T. Impact of anti-angiogenic treatments on metastatic renal cell carcinoma. Expert Rev Anticancer Ther 2009, 9(12): 1793-805.
    • (2009) Expert Rev Anticancer Ther , vol.9 , Issue.12 , pp. 1793-1805
    • Ainsworth, N.L.1    Lee, J.S.2    Eisen, T.3
  • 32
    • 50249092801 scopus 로고    scopus 로고
    • Heterogeneity of kinase inhibitor resistance mechanisms in GIST
    • Liegl, B., Kepten, I., Le, C. et al. Heterogeneity of kinase inhibitor resistance mechanisms in GIST. J Pathol 2008, 216(1): 64-74.
    • (2008) J Pathol , vol.216 , Issue.1 , pp. 64-74
    • Liegl, B.1    Kepten, I.2    Le, C.3
  • 36
    • 59949103514 scopus 로고    scopus 로고
    • Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] Abst 10502
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 10502.
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Wiebe, L.1    Kasza, K.E.2    Maki, R.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.