High on-aspirin platelet reactivity predicts cardiac death in acute coronary syndrome patients undergoing PCI

European Journal of Internal Medicine

Volumn 30, Issue , 2016, Pages 49-54

  Gori, Anna Maria ^a,b   Grifoni, Elisa ^a   Valenti, Renato ^c   Giusti, Betti ^a   Paniccia, Rita ^a   Parodi, Guido ^c   Migliorini, Angela ^c   Antoniucci, David ^c   Abbate, Rosanna ^a   Gensini, Gian Franco ^a,b   Marcucci, Rossella ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

Acute coronary syndrome; Aspirin resistance; High on treatment platelet reactivity; Platelet reactivity

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ELUTING STENT; FEMALE; FOLLOW UP; HAZARD RATIO; HEART DEATH; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HYPERTENSION; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PLATELET REACTIVITY; PREDICTIVE VALUE; PREVALENCE; PROSPECTIVE STUDY; RISK FACTOR; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STENT THROMBOSIS; THROMBOELASTOGRAPHY; UNSTABLE ANGINA PECTORIS; VERY ELDERLY; ANALOGS AND DERIVATIVES; DEATH; DRUG EFFECTS; ITALY; KAPLAN MEIER METHOD; MORTALITY; THROMBOCYTE;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; ASPIRIN; BLOOD PLATELETS; DEATH; DRUG-ELUTING STENTS; FEMALE; HUMANS; ITALY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PERCUTANEOUS CORONARY INTERVENTION; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; TICLOPIDINE;

EID: 84952924827     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2015.12.003     Document Type: Article

References (32)

1. U.S. Tantry, L. Bonello, D. Aradi, and et al. Working group on on-treatment platelet reactivity. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding J Am Coll Cardiol 62 2013 2261 2267
2. G. Parodi, R. Marcucci, R. Valenti, and et al. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI JAMA 306 2011 1215 1223
3. P. Pignatelli, S. Di Santo, F. Barillà, and et al. Multiple anti-atherosclerotic treatments impair aspirin compliance: effects on aspirin resistance J Thromb Haemost 6 2008 1832 1834
4. A.A. Pettersen, H. Arnesen, and I. Seljeflot A brief review on high on-aspirin residual platelet reactivity Vascul Pharmacol 67-69 2015 6 9
5. F. Sofi, R. Marcucci, A.M. Gori, R. Abbate, and G.F. Gensini Residual platelet reactivity on aspirin therapy and recurrent cardiovascular events - a meta-analysis Int J Cardiol 18 128 2008 166 171
6. P.A. Gum, K. Kottke-Marchant, P.A. Welsh, J. White, and E.J. Topol A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease J Am Coll Cardiol 41 2003 961 965
7. R. Marcucci, R. Paniccia, E. Antonucci, and et al. Usefulness of aspirin resistance after percutaneous coronary intervention for acute myocardial infarction in predicting one-year major adverse coronary events Am J Cardiol 98 2006 1156 1159
8. A.L. Frelinger, Y. Li, M.D. Linden, and et al. Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization Circulation 120 2009 2586 2596
9. M. Wurtz, E.L. Grove, L.N. Wulff, and et al. Patients with previous definite stent thrombosis have a reduced antiplatelet effect of aspirin and a larger fraction of immature platelets JACC Cardiovasc Interv 3 2010 828 835
10. K. Mayer, I. Bernlochner, S. Braun, and et al. Aspirin treatment and outcomes after percutaneous coronary intervention: results of the ISAR-ASPI registry J Am Coll Cardiol 64 2014 863 871
11. G.W. Stone, B. Witzenbichler, G. Weisz, and et al. ADAPT-DES investigators. Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study Lancet 382 2013 614 623
12. S. Silber, P. Albertsson, F.F. Avilés, and et al. Task force for percutaneous coronary interventions of the European society of cardiology. Guidelines for percutaneous coronary interventions. The task force for percutaneous coronary interventions of the European society of cardiology Eur Heart J 26 2005 804 847
13. A.M. Gori, R. Marcucci, A. Migliorini, and et al. Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents J Am Coll Cardiol 52 2008 734 739
14. D.E. Cutlip, S. Windecker, R. Mehran, and et al. Academic research consortium. Clinical end points in coronary stent trials: a case for standardized definitions Circulation 115 2007 2344 2351
15. V. Xanthakis, L.M. Sullivan, R.S. Vasan, and et al. Assessing the incremental predictive performance of novel biomarkers over standard predictors Stat Med 33 2014 2577 2584
16. J.L. Mega, T. Simon, J.P. Collet, and et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis JAMA 304 2010 1821 1830
17. R. Marcucci, C. Cenci, G. Cioni, A. Lombardi, B. Giusti, and G.F. Gensini Antiplatelets in acute coronary syndrome: personal perspectives Expert Rev Cardiovasc Ther 10 2012 1487 1496
18. J.S. Hulot, J.P. Collet, J. Silvain, and et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19∗2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis J Am Coll Cardiol 56 2010 134 143
19. M. Leoncini, A. Toso, M. Maioli, and et al. High-dose atorvastatin on the pharmacodynamic effects of double-dose clopidogrel in patients undergoing percutaneous coronary interventions: the ACHIDO (atorvastatin and clopidogrel high dose in stable patients with residual high platelet activity) study JACC Cardiovasc Interv 6 2013 169 179
20. R. Marcucci, S. Valente, A.M. Gori, and et al. Global platelet hyperreactivity and elevated C-reactive protein levels predict long term mortality in STEMI patients Thromb Res 134 2014 884 888
21. G. Patti, R. De Caterina, R. Abbate, and et al. Working group on thrombosis of the Italian society of cardiology. Platelet function and long-term antiplatelet therapy in women: is there a gender-specificity? A 'state-of-the-art' paper Eur Heart J 35 2014 2213 2223
22. R. Marcucci, G. Cioni, B. Giusti, and et al. Gender and anti-thrombotic therapy: from biology to clinical implications J Cardiovasc Transl Res 7 2014 72 81
23. M. Becatti, C. Fiorillo, A.M. Gori, and et al. Platelet and leukocyte ROS production and lipoperoxidation are associated with high platelet reactivity in non-ST elevation myocardial infarction (NSTEMI) patients on dual antiplatelet treatment Atherosclerosis 231 2013 392 400
24. F. Cesari, R. Marcucci, A.M. Gori, and et al. Reticulated platelets predict cardiovascular death in acute coronary syndrome patients. Insights from the AMI-Florence 2 study Thromb Haemost 109 2013 846 853
25. R. Marcucci, B. Giusti, R. Paniccia, and et al. High on-treatment platelet reactivity by ADP and increased risk of MACE in good clopidogrel metabolizers Platelets 23 2012 586 593
26. A.M. Gori, R. Marcucci, R. Paniccia, and et al. Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function Thromb Haemost 100 2008 1136 1145
27. S.H. Simpson, A.S. Abdelmoneim, D. Omran, and T.R. Featherstone Prevalence of high on-treatment platelet reactivity in diabetic patients treated with aspirin Am J Med 127 95 2014 e1 e9
28. B. Rocca, F. Santilli, D. Pitocco, and et al. The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes J Thromb Haemost 10 2012 1220 1230
29. L. Fang, and J. Zheng The changes of platelet and platelet activation markers in acute coronary syndrome patients Clin Lab 59 2013 1339 1342
30. P. Buonamici, R. Marcucci, A. Migliorini, and et al. Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis J Am Coll Cardiol 49 2007 2312 2317
31. G. Parodi, B. Bellandi, I. Xanthopoulou, and et al. Morphine is associated with a delayed activity of oral antiplatelet agents in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention Circ Cardiovasc Interv 8 1 2014 (pii: e001593)
32. G. Parodi, I. Xanthopoulou, B. Bellandi, and et al. Ticagrelor crushed tablets administration in STEMI patients: the MOJITO study J Am Coll Cardiol 65 2015 511 512