Reticulated platelets predict cardiovascular death in acute coronary syndrome patients: Insights from the AMI-florence 2 study

Thrombosis and Haemostasis

Volumn 109, Issue 5, 2013, Pages 846-853

  Cesari, Francesca ^a   Marcucci, Rossella ^a   Gori, Anna Maria ^b   Caporale, Roberto ^a   Fanelli, Alessandra ^a   Casola, Giulia ^a   Balzi, Daniela ^c   Barchielli, Alessandro ^c   Valente, Serafina ^a   Giglioli, Cristina ^a   Gensini, Gian Franco ^b   Abbate, Rosanna ^a  

^a CAREGGI UNIVERSITY HOSPITAL   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c Local Health Unit 10   (Italy)

Author keywords

Acute coronary syndrome; Cardiovascular death; Platelet turn over; Reticulated platelets

Indexed keywords

FIBRINOGEN RECEPTOR; HEMOGLOBIN;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLOOD CELL COUNT; BLOOD SAMPLING; CARDIOVASCULAR RISK; CORRELATION ANALYSIS; DIAGNOSTIC TEST ACCURACY STUDY; ERYTHROCYTE; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HEART DEATH; HEMATOCRIT; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE VOLUME;

ACUTE CORONARY SYNDROME; ADULT; AGED; AGED, 80 AND OVER; ANGINA, UNSTABLE; AREA UNDER CURVE; BLOOD PLATELETS; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; ITALY; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; ODDS RATIO; PLATELET COUNT; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REGISTRIES; RISK FACTORS; ROC CURVE; TIME FACTORS;

EID: 84877017690     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-09-0709     Document Type: Article

References (39)

1. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005; 115: 3378-3384.
2. Sofi F, Marcucci R, Gori AM, et al. Clopidogrel non responsiveness and risk of cardiovascular morbidity. An updated meta-analysis. Thromb haemost 2010; 103: 841-848.
3. Parodi G, Marcucci R, Valenti R, et al. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI. J Am Med Assoc 2011; 306: 1215-1223.
4. Karpatkin S. Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets. J Clin Invest 1969; 48: 1083-1087.
5. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561-1571.
6. Harrison P, Goodall AH. "Message in the platelet" - more than just vestigial mRNA. Platelets 2008; 19: 395-404.
7. Monteagudo Jimenez M, Amengual Guedan MJ, Munoz Martin L, et al. Measurement of reticulated platelets by simple flow cytometry: an indirect thrombocytopoietic marker. Eur J Int Med 2006; 17: 541-544.
8. Saxon BR, Blanchette VS, Butchard S, et al. Reticulated platelets count in the diagnosis of acute immune thrombocytopenic purpura. J Pediatric Hematol Oncol 1998; 20: 44-48.
9. Kurata Y, Hayashi S, Kiyoi T, et al. Diagnostic value test for reticulated platelets, plasma glycocalicin and thrombopoietin levels for discriminating between hyperdestructive and hypoplastic thrombocytopenia. Am J Clin Pathol 2001; 115: 656-664.
10. Nakamura T, Uchiyama S, Yamazaki M, et al. Flow cytometric analysis of reticulated platelets in patients with ischemic stroke. Thromb Res 2002; 106: 171-177.
11. Würtz M, Grove EL, Wulff LN, et al. Patients with previous definite stent thrombosis have a reduced antiplatelet effect of aspirin and a larger fraction of immature platelets. JACC Cardiovasc Interv. 2010; 3: 828-835.
12. Lakkis N, Dokainish H, Abuzahara M, et al. Reticulated platelets in acute coronary syndrome: a marker of platelet activity. J Am Coll Cardiol 2004; 10: 2087-2098.
13. Cesari F, Marcucci R, Caporale R, et al. Relationship between high platelet turnover and platelet function in high-risk patients with coronary artery disease on dual antiplatelet therapy. Thromb Haemost 2008; 99: 930-935.
14. Guthikonda S, Alviar CL, Vaduganathan M, et al. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease. J Am Coll Cardiol 2008; 52: 743-749.
15. Grove EL, Hvas AM, Mortensen SB, et al. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011; 9: 185-191.
16. Würtz M, Wulff LN, Grove EL, et al. Influence of renal function and platelet turnover on the antiplatelet effect of aspirin. Thromb Res 2012; 129: 434-440.
17. Hamm CW, Bassand JP, Agewall S, et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2011; 32: 2999-3054.
18. Cifkova R, Erdine S, Fagard R, et al. ESH/ESC Hypertension Guidelines Committee Practice guidelines for primary care physicians: 2003 ESH/ESC Hypertension guidelines. J Hypertens 2003; 21: 1779-1786.
19. Report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes Care 2003; 26: 5-20.
20. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adult (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-3421.
21. Briggs C, Kunka S, Hart D, et al. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia Br J Haematol 2004; 126: 93-99.
22. Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in the elderly patients with risk factors for atherosclerosis. Clin Lab Haematol 1992; 14: 281-287.
23. Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475-478.
24. Jakubowski JA, Thompson CB, Vaillancourt R, et al. Arachidonic acid metabolism by platelets of differing size. Br J Haematol 1983; 53: 503-511.
25. Grove EL, Hvas AM, Kristensen SD. Immature platelets in patients with acute coronary syndromes. Thromb Haemost 2009; 101: 151-156.
26. Martin JF, Trowbridge EA, Salmon GL, et al. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nucler DNA concentration. Thromb Res 1983; 32: 443-460.
27. Tschoepe D, Roesen P, Kauffmann L, et al. Evidence for abnormal platelet glycoprotein expression in diabetes mellitus. Eur J Clin Invest 1990; 20: 166-170.
28. Watala C. Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitus. Curr Pharm Des 2005; 11: 2331-2365.
29. Guthikonda S, Lev EI, Patel R, et al. Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. J Thromb Haemost 2007; 5: 490-496.
30. Perneby C, Wallen NH, Rooney C, et al. Dose and time-dependent antiplatelet effects of aspirin. Thromb Haemost 2006; 95: 652-658.
31. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. Thromb Haemost 2010; 8: 148-156.
32. Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475-478.
33. Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy. Ann Med 2004; 36: 552-557.
34. Pathansali R, Smith N, Bath P. altered megakaryocyte-platelet haemostatic axis in hypercholesterolemia. Platelets 2001; 12: 292-297.
35. Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol 1992; 14: 281-287.
36. Coban E, Ozdogan M, Yazicioglu G, et al. The mean platelet volume in patients with obesity. Int J Clin Pract 2005; 59: 981-982.
37. Brambilla M, Camera M, Colnago D, et al. Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet-leukocyte aggregates. Arterioscler Thromb vasc Biol 2008; 28: 947-953.
38. Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediate inflammatory signalling by regulated interleukin 1 synthesis. J Cell Biol 2001; 154: 485-490.
39. Matic GB, Chapman ES, Zaiss M, et al. Whole blood analysis of reticulated platelets: improvements of detection and assay stability. Cytometry 1998; 34: 229-234.