Heritability of autism spectrum disorders: A meta-analysis of twin studies

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 57, Issue 5, 2016, Pages 585-595

  Tick, Beata ^a   Bolton, Patrick ^a   Happé, Francesca ^a   Rutter, Michael ^a   Rijsdijk, Frühling ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Autism spectrum disorders; DF extremes analysis; heritability; meta analysis; twin studies

Indexed keywords

AUTISM SPECTRUM DISORDER; GENETIC PREDISPOSITION; GENETICS; HUMAN; META ANALYSIS; TWINS;

AUTISM SPECTRUM DISORDER; DISEASES IN TWINS; GENETIC PREDISPOSITION TO DISEASE; HUMANS;

EID: 84952908413     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/jcpp.12499     Document Type: Article

References (36)

1. Bailey, A., Lecouteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., &, Rutter, M., (1995). Autism as a strongly genetic disorder-evidence from a British twin study. Psychological Medicine, 25, 63-77.
2. Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., &, Charman, T., (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The Special Needs and Autism Project (SNAP). The Lancet, 368, 210-215.
3. Baxter, A.J., Brugha, T.S., Erskine, H.E., Scheurer, R.W., Vos, T., &, Scott, J.G., (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45, 601-613.
4. Brugha, T.S., McManus, S., Bankart, J., Scott, F., Purdon, S., Smith, J.,... &, Meltzer, H., (2011). Epidemiology of autism spectrum disorders in adults in the community in England. Archives of General Psychiatry, 68, 459-465.
5. Colvert, E., Tick, B., McEwen, F., Stewart, C., Curran, S., Woodhouse, E.,... &, Bolton, P., (2015). Heritability of autism spectrum disorder in a UK population-based twin sample. JAMA Psychiatry, 72, 415.
6. Cooper, H., Hedges, L.V., &, Valentine, J.C., (2009). The handbook of research synthesis and meta-analysis (2nd edn). New York: The Russell Sage Foundation.
7. DeFries, J.C., &, Fulker, D.W., (1985). Multiple regression analysis of twin data. Behavior Genetics, 15, 467-473.
8. Elsabbagh, M., Divan, G., Koh, Y.-J., Kim, Y.S., Kauchali, S., Marcín, C.,... &, Fombonne, E., (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Research, 5, 160-179.
9. Folstein, S., &, Rutter, M., (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297-321.
10. Frazier, T.W., Thompson, L., Youngstrom, E.A., Law, P., Hardan, A.Y., Eng, C., &, Morris, N., (2014). A twin study of heritable and shared environmental contributions to autism. Journal of Autism and Developmental Disorders, 44, 2013-2025.
11. Gaugler, T., Klei, L., Sanders, S.J., Bodea, C.A., Goldberg, A.P., Lee, A.B.,... &, Buxbaum, J.D., (2014). Most genetic risk for autism resides with common variation. Nature Genetics, 46, 881-885.
12. Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T.,... &, Risch, N., (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68, 1095-1102.
13. Haworth, C.M.A., Davis, O.S.P., &, Plomin, R., (2013). Twins early development study (TEDS): A genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood. Twin Research and Human Genetics, 16, 117-125.
14. Iossifov, Y., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y.,... &, Wigler, M., (2015), Low load for disruptive mutations in autism genes and their biased transmission. Proceedings of the National Academy of Sciences of the United States of America, 112, E5600-7.
15. Le Couteur, A., Bailey, A., Goode, S., Pickles, A., Gottesman, I., Robertson, S., &, Rutter, M., (1996). A broader phenotype of autism: The clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785-801.
16. Le Couteur, A., &, Szatmari, P., (2015). Ch 51: 'Autism spectrum disorder '. In, A.T.D.S. Pine, J.F. Leckman, S. Scott, M.J. Snowling, &, E.A. Taylor, (Eds.), Rutter's child and adolescent psychiatry (6th edn, pp. 665). Oxford, UK: Wiley-Blackwell.
17. Lichtenstein, P., Carlström, E., Rästam, M., Gillberg, C., &, Anckarsäter, H., (2010). The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. The American Journal of Psychiatry, 167, 1357-1363.
18. Lord, C., Rutter, M., &, Couteur, A.L., (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive devel-opmental disorders. Journal of Autism and Developmental Disorders, 24, 659-685.
19. Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., &, Schopler, E., (1989). Austism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185-212.
20. Maxwell, C.R., Parish-Morris, J., Hsin, O., Bush, J.C., &, Schultz, R.T., (2013). The broad autism phenotype predicts child functioning in autism spectrum disorders. Journal of Neurodevelopmental Disorders, 5, 25.
21. Neale, M.C., Boker, S.M., Xie, G., &, Maes, H.H., (2003). Mx: Statistical modeling. Richmond, VA: Department of Psychiatry.
22. Neale, M.C., &, Cardon, L.R., (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publishers.
23. Nordenbæk, C., Jørgensen, M., Kyvik, K.O., &, Bilenberg, N., (2014). A Danish population-based twin study on autism spectrum disorders. European Child and Adolescent Psychiatry, 23, 35-43.
24. Plomin, R., DeFries, J.C., Knopik, V.S., &, Neiderhiser, J.M., (2013). Behavioral genetics (6th edn). New York: Worth Publishers.
25. Purcell, S., &, Sham, P.C., (2003). A model-fitting implementation of the DeFries-Fulker model for selected twin data. Behavior Genetics, 33, 271-278.
26. Rijsdijk, F.V., &, Sham, P.C., (2002). Analytic approaches to twin data using structural equation models. Briefings in Bioinformatics, 3, 119-133.
27. Ritvo, E.R., Freeman, B.J., Mason-Brothers, A., Mo, A., &, Ritvo, A.M., (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins. The American Journal of Psychiatry, 142, 74-77.
28. Ronald, A., &, Hoekstra, R.A., (2011). Autism spectrum disorders and autistic traits: A decade of new twin studies. American Journal of Medical Genetics Part B-Neu-ropsychiatric Genetics, 156B, 255-274.
29. Rosenberg, R.E., Law, J.K., Yenokyan, G., McGready, J., Kaufmann, W.E., &, Law, P.A., (2009). Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Archives of Pediatrics & Adolescent Medicine, 163, 907-914.
30. Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C.M., &, Reichenberg, A., (2014). The familial risk of autism. Journal of the American Medical Association, 311, 1770-1777.
31. Sasson, N.J., Lam, K.S., Parlier, M., Daniels, J.L., &, Piven, J., (2013). Autism and the broad autism phenotype: Familial patterns and intergenerational transmission. Journal of Neurodevelopmental Disorders, 5, 11.
32. Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I.C., Jakobsson, G., &, Bohman, M., (1989). A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden. Journal of Child Psychology and Psychiatry, 30, 405-416.
33. Sullivan, P.F., Kendler, K.S., &, Neale, M.C., (2003). Schizophrenia as a complex trait. Archives of General Psychiatry, 60, 1187-1192.
34. Taniai, H., Nishiyama, T., Miyachi, T., Imaeda, M., &, Sumi, S., (2008). Genetic influences on the broad spectrum of autism: Study of proband-ascertained twins. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B, 844-849.
35. Williams, J.G., Allison, C., Scott, F.J., Bolton, P.F., Baron-Cohen, S., Matthews, F.E., &, Brayne, C., (2008). The Childhood Autism Spectrum Test (CAST): Sex differences. Journal of Autism and Developmental Disorders, 38, 1731-1739.
36. Williams, J., Scott, F., Stott, C., Allison, C., Bolton, P., Baron-Cohen, S., &, Brayne, C., (2005). The CAST (Childhood Asperger and Syndrome Test)-Test accuracy. Autism: The International Journal of Research and Practice, 9, 45-68.