Gone fission: An asymptomatic STAT2 mutation elongates mitochondria and causes human disease following viral infection

Brain

Volumn 138, Issue 10, 2015, Pages 2802-2806

  Dasgupta, Asish ^a   Chen, Kuang Hueih ^a   Tian, Lian ^a   Archer, Stephen L ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

STAT2 PROTEIN;

CELL ELONGATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE MUTATION; HUMAN; IMMUNOCOMPETENT CELL; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; NOTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VIRUS INFECTION; DEFICIENCY; FEMALE; GENETICS; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

FEMALE; HUMANS; MALE; MITOCHONDRIAL DISEASES; MITOCHONDRIAL DYNAMICS; SIGNAL TRANSDUCTION; STAT2 TRANSCRIPTION FACTOR;

EID: 84952885908     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv237     Document Type: Note

References (13)

1. Archer SL. Mitochondrial dynamics- mitochondrial fission and fusion in human diseases. N Engl J Med 2013; 369: 2236-51.
2. Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, et al. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation 2010; 121: 2661-71.
3. Cho B, Cho HM, Kim HJ, Jeong J, Park SK, Hwang EM, et al. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med 2014; 46: e105.
4. Goswami R, Majumdar T, Dhar J, Chattopadhyay S, Bandyopadhyay SK, Verbovetskaya V, et al. Viral degradasome hijacks mitochondria to suppress innate immunity. Cell Res 2013; 23: 1025-42.
5. Hambleton S, Goodbourn S, Young DF, Dickinson P, Mohamad SM, Valappil M, et al. STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci USA 2013; 110: 3053-8.
6. Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD, Counter CM. RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol 2011; 13: 1108-15.
7. Kashatus JA, Nascimento A, Myers LJ, Sher A, Byrne FL, Hoehn KL, et al. Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. Mol Cell 2015; 57: 537-51.
8. Meier JA, Larner AC. Toward a new STATe: the role of STATs in mitochondrial function. Semin Immunol 2014; 26: 20-8.
9. Shahni R, Cale CM, Anderson G, Osellame LD, Hambleton S, Jacques TS, et al. Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission. Brain 2015. Advance Access published on Jun 29, 2015.
10. Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012; 148: 228-43.
11. Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, et al. Function of mitochondrial Stat3 in cellular respiration. Science 2009; 323: 793-7.
12. Wikstrom JD, Israeli T, Bachar-Wikstrom E, Swisa A, Ariav Y, Waiss M, et al. AMPK regulates ER morphology and function in stressed pancreatic beta-cells via phosphorylation of DRP1. Mol Endocrinol 2013; 27: 1706-23.
13. Zhu PP, Patterson A, Stadler J, Seeburg DP, Sheng M, Blackstone C. Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1. J Biol Chem 2004; 279: 35967-74.