In children and youth with mild and moderate traumatic brain injury, glial fibrillary acidic protein out-performs s100β in detecting traumatic intracranial lesions on computed tomography

Journal of Neurotrauma

Volumn 33, Issue 1, 2016, Pages 58-64

  Papa, Linda ^a,b   Mittal, Manoj K ^c,d   Ramirez, Jose ^b   Ramia, Michelle ^a   Kirby, Sara ^c   Silvestri, Salvatore ^a,b   Giordano, Philip ^a,b   Weber, Kurt ^a,b   Braga, Carolina F ^a   Tan, Ciara N ^a   Ameli, Neema J ^a   Lopez, Marco ^a   Zonfrillo, Mark ^c,d  

^a ORLANDO REGIONAL MEDICAL CENTER   (United States)

^b ARNOLD PALMER HOSPITAL FOR CHILDREN   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

computed tomography (CT); glialfibrillary acidic protein (GFAP); head trauma; mild traumatic brain injury; S100B

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN S100B; BIOLOGICAL MARKER;

ADOLESCENT; ADULT; ARTICLE; BRAIN DAMAGE; CHILD; CHILDHOOD DISEASE; CHILDHOOD INJURY; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EMERGENCY HEALTH SERVICE; FEMALE; HEAD INJURY; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SERUM; TRAUMATIC BRAIN INJURY; BLOOD; BRAIN INJURY; DIAGNOSTIC IMAGING; INFANT; NEWBORN; PRESCHOOL CHILD; SENSITIVITY AND SPECIFICITY; X-RAY COMPUTED TOMOGRAPHY; YOUNG ADULT;

ADOLESCENT; ADULT; BIOMARKERS; BRAIN INJURIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; INFANT; INFANT, NEWBORN; MALE; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; TRAUMA CENTERS; YOUNG ADULT;

EID: 84952884487     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2015.3869     Document Type: Article

References (26)

1. Papa L, Ramia M.M, Kelly J.M, Burks S.S, Pawlowicz A, and Berger R.P. (2013). Systematic review of clinical research on biomarkers for pediatric traumatic brain injury. J Neurotrauma. 30, 324-338.
2. Brenner D.J. (2002). Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative. Pediatr. Radiol. 32, 228-223.
3. Brenner D.J and Hall E.J. (2007). Computed tomography-An increasing source of radiation exposure. N. Engl. J. Med. 357, 2277-2284.
4. Berger R.P, Pierce M.C, Wisniewski S.R, Adelson P.D, and Kochanek P.M. (2002). Serum S100B concentrations are increased after closed head injury in children: a preliminary study. J. Neurotrauma. 19, 1405-1409.
5. Swanson C.A, Burns J.C, and Peterson B.M. (2010). Low plasma D-dimer concentration predicts the absence of traumatic brain injury in children. J. Trauma. 68, 1072-1077.
6. Bechtel K, Frasure S, Marshall C, Dziura J, and Simpson C. (2009). Relationship of serum S100B levels and intracranial injury in children with closed head trauma. Pediatrics 124, e697-e704.
7. Castellani C, Bimbashi P, Ruttenstock E, Sacherer P, Stojakovic T, and Weinberg A.M. (2009). Neuroprotein s-100B-A useful parameter in paediatric patients with mild traumatic brain injury? Acta Paediatr. 98, 1607-1612.
8. Rothoerl R.D. and Woertgen C. (2001). High serum S100B levels for trauma patients without head injuries. Neurosurgery. 49, 1490-1491.
9. Romner B. and Ingebrigtsen T. (2001). High serum S100B levels for trauma patients without head injuries. Neurosurgery. 49, 1490.
10. Anderson R.E, Hansson L.O, Nilsson O, Dijlai-Merzoug R, and Settergen G. (2001). High serum S100B levels for trauma patients without head injuries. Neurosurgery. 49, 1272-1273.
11. Pelinka L.E, Kroepfl A, Schmidhammer R, Krenn M, Buchinger W, Redl H, and Raabe A. (2004). Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma. J. Trauma. 57, 1006-1012.
12. Unden J, Bellner J, Eneroth M, Alling C, Ingebrigtsen T, and Romner B. (2005). Raised serum S100B levels after acute bone fractures without cerebral injury. J. Trauma. 58, 59-61.
13. Zimmer D.B, Cornwall E.H, Landar A, and Song W. (1995). The S100 protein family: history, function, and expression. Brain Res. Bull. 37, 417-429.
14. Olsson B, Zetterberg H, Hampel H, and Blennow K. (2011). Biomarker-based dissection of neurodegenerative diseases. Prog. Neurobiol. 95, 520-534.
15. Papa L, Lewis L.M, Falk J.L, Zhang Z, Silvestri S, Giordano P, Brophy G.M, Demery J.A, Dixit N.K, Ferguson I, Liu M.C, Mo J, Akinyi L, Schmid K, Mondello S, Robertson C.S, Tortella F.C, Hayes R.L, and Wang K.K. (2012). Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Ann. Emerg. Med. 59, 471-483.
16. Metting Z, Wilczak N, Rodiger L.A, Schaaf J.M, and van der Naalt J. (2012). GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology. 78, 1428-1433.
17. Diaz-Arrastia R, Wang K.K, Papa L, Sorani M.D, Yue J.K, Puccio A.M, McMahon P.J, Inoue T, Yuh E.L, , Lingsma H.F, Maas A.I, Valadka A.B, Okonkwo D.O, Manley G.T, Casey I.S, Cheong M, Cooper S.R, Dams-O'Connor K, Gordon W.A, Hricik A.J, Menon D.K, Mukherjee P, Schnyer D.M, Sinha T.K, and Vassar M.J. (2014). Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-Terminal hydrolase-L1 and glial fibrillary acidic protein. J. Neurotrauma. 31, 19-25.
18. Papa L, Silvestri S, Brophy G.M, Giordano P, Falk J.L, Braga C.F, Tan C.N, Ameli N.J, Demery J.A, Dixit N.K, Mendes M.E, Hayes R.L, Wang K.K, and Robertson C.S. (2014). GFAP out-performs S100beta in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions. J. Neurotrauma. 31, 1815-1822.
19. Eng L.F, Vanderhaeghen J.J, Bignami A, and Gerstl B. (1971). An acidic protein isolated from fibrous astrocytes. Brain Res. 28, 351-354.
20. Honda M, Tsuruta R, Kaneko T, Kasaoka S, Yagi T, Todani M, Fujita M, Izumi T, and Maekawa T. (2010). Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J. Trauma. 69, 104-109.
21. Pelinka L.E, Kroepfl A, Leixnering M, Buchinger W, Raabe A, and Redl H. (2004). GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. J. Neurotrauma. 21, 1553-1561.
22. Vajtr, D, Benada, O, Linzer P, Samal F, Springer, D, Strejc P, Beran M, Prusa R, and Zima T. (2013). Immunohistochemistry and serum values of S-100B, glial fibrillary acidic protein, and hyperphosphorylated neurofilaments in brain injuries. Soud Lek. 57, 7-12.
23. Kuppermann N, Holmes J.F, Dayan P.S, Hoyle J.D, Jr, Atabaki S.M, Holubkov R, Nadel F.M, Monroe D, Stanley R.M, Borgialli D.A, Badawy M.K, Schunk J.E, Quayle K.S, Mahajan P, Lichenstein R, Lillis K.A, Tunik M.G, Jacobs E.S, Callahan J.M, Gorelick M.H, Glass T.F, Lee L.K, Bachman M.C, Cooper A, Powell E.C, Gerardi M.J, Melville K.A, Muizelaar J.P, Wisner D.H, Zuspan S.J, Dean J.M, and Wootton-Gorges S.L. (2009). Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet. 374, 1160-1170.
24. Osmond M.H, Klassen T.P, Wells G.A, Correll R, Jarvis A, Joubert G, Bailey B, Chauvin-Kimoff L, Pusic M, McConnell D, Nijssen-Jordan C, Silver N, Taylor B, and Stiell I.G. (2010). CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury. CMAJ. 182, 341-348.
25. Dunning J, Daly J.P, Lomas J.P, Lecky F, Batchelor J, and Mackway-Jones K. (2006). Derivation of the childrens head injury algorithm for the prediction of important clinical events decision rule for head injury in children. Arch. Dis. Child. 91, 885-891.
26. Easter J.S, Bakes K, Dhaliwal J, Miller M, Caruso E, and Haukoos J.S. (2014). ComParison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study. Ann. Emerg. Med. 64, 145-152.