Low plasma d-dimer concentration predicts the absence of traumatic brain injury in children

Journal of Trauma - Injury, Infection and Critical Care

Volumn 68, Issue 5, 2010, Pages 1072-1077

  Swanson, Craig A ^a   Burns, Jane C ^a   Peterson, Brad M ^a  

^a Sutter Medical Center   (United States)

Author keywords

Biomarker; CT; D dimer; Head trauma

Indexed keywords

BLOOD CLOTTING FACTOR; D DIMER; GELATINASE B; PROTEIN S100B;

ARTICLE; BLOOD ANALYSIS; BLOOD CELL COUNT; CHILD; CHILDHOOD INJURY; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EMERGENCY HEALTH SERVICE; FEMALE; HUMAN; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; SCHOOL CHILD; TRAUMATIC BRAIN INJURY;

ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BRAIN INJURIES; CALIFORNIA; CHILD; CHILD, PRESCHOOL; DISCRIMINANT ANALYSIS; EMERGENCY TREATMENT; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; GLASGOW COMA SCALE; HOSPITALS, PEDIATRIC; HUMANS; LOGISTIC MODELS; MALE; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, X-RAY COMPUTED; TRAUMA CENTERS;

EID: 77952275066     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181d7a6f2     Document Type: Article

References (28)

1. White JR, Farukhi Z, Bull C, et al. Predictors of outcome in severely head-injured children. Crit Care Med. 2001;29:534-540.
2. Stein SC, Burnett MG, Glick HA. Indications for CT scanning in mild traumatic brain injury: a cost-effectiveness study. J Trauma. 2006;61:558-566.
3. Brenner DJ, Hall EJ. Computed tomography-an increasing source of radiation exposure. N Engl J Med. 2007;357:2277-2284.
4. Dunning J, Daly JP, Lomas JP, Lecky F, Batchelor J, Mackway-Jones K; Children's Head Injury Algorithm for the Prediction of Important Clinical Events Study Group. Derivation of the children's head injury algorithm for the prediction of important clinical events decision rule for head injury in children. Arch Dis Child. 2006;91:885-891.
5. Stiell IG, Wells GA, Vandemheen K, et al. The Canadian CT Head Rule for patients with minor head injury. Lancet. 2001;357:1391-1396.
6. Smits M, Dippel DW, de Haan GG, et al. Minor head injury: guidelines for the use of CT-a multicenter validation study. Radiology. 2007;245:831-838.
7. Haydel MJ, Preston CA, Mills TJ, Luber S, Blaudeau E, DeBlieux PM. Indications for computed tomography in patients with minor head injury. N Engl J Med. 2000;343:100-105.
8. Dunning J, Stratford-Smith P, Lecky F, et al; Emergency Medicine Research Group. A meta-analysis of clinical correlates that predict significant intracranial injury in adults with minor head trauma. J Neurotrauma. 2004;21:877-885. (Pubitemid 38998915)
9. Dunning J, Batchelor J, Stratford-Smith P, et al. A meta-analysis of variables that predict significant intracranial injury in minor head trauma. Arch Dis Child. 2004;89:653-659.
10. Stiell IG, Clement CM, Rowe BH, et al. Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury. JAMA. 2005;294:1511-1518.
11. Bakhtiari K, Meijers JC, de Jonge E, Levi M. Prospective evaluation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004;32:2416-2421.
12. Blackwell CD, Gorelick M, Holmes JF, Bandyopadhyay S, Kuppermann N. Pediatric head trauma: changes in use of computed tomography in emergency departments in the United States over time. Ann Emerg Med. 2007;49:320-324.
13. Muller K, Townend W, Biasca N, et al. S100B serum level predicts computed tomography findings after minor head injury. J Trauma. 2007;62:1452-1456.
14. Biberthaler P, Linsenmeier U, Pfeifer KJ, et al. Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter study. Shock. 2006;25:446-453.
15. Pickering A, Carter J, Hanning I, Townend W. Emergency department measurement of urinary S100B in children following head injury: can extracranial injury confound findings? Emerg Med J. 2008;25:88-89.
16. Piazza O, Storti MP, Cotena S, et al. S100B is not a reliable prognostic index in paediatric TBI. Pediatr Neurosurg. 2007;43:258-264.
17. Harhangi BS, Kompanje EJ, Leebeek FW, Maas AI. Coagulation disorders after traumatic brain injury. Acta Neurochir (Wien). 2008;150:165-175;
18. Morel N, Morel O, Petit L, et al. Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J Trauma. 2008;64:698-704.
19. Murray GD, Butcher I, McHugh GS, et al. Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study. J Neurotrauma. 2007;24:329-337. (Pubitemid 46492154)
20. Bayir A, Kalkan E, Kocak S, Ak A, Cander B, Bodur S. Fibrinolytic markers and neurologic outcome in traumatic brain injury. Neurol India. 2006;54:363-365.
21. Delgado P, Alvarez-Sabin J, Abilleira S, et al. Plasma D-dimer predicts poor outcome after acute intracerebral hemorrhage. Neurology. 2006;67:94-98. (Pubitemid 44305468)
22. Smits M, Dippel DW, de Haan GG, et al. External validation of the Canadian CT Head Rule and the New Orleans Criteria for CT scanning in patients with minor head injury. JAMA. 2005;294:1519-1525.
23. Haydel MJ, Shembekar AD. Prediction of intracranial injury in children aged five years and older with loss of consciousness after minor head injury due to nontrivial mechanisms. Ann Emerg Med. 2003;42:507-514.
24. Wells PS, Anderson DR, Rodger M, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003;349:1227-1235.
25. Sosothikul D, Seksarn P, Lusher JM. Pediatric reference values for molecular markers in hemostasis. J Pediatr Hematol Oncol. 2007;29:19-22.
26. Andrew M, Paes B, Johnston M. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol. 1990;12:95-104.
27. Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L. Maturation of the hemostatic system during childhood. Blood. 1992;80:1998-2005.
28. Meythaler JM, Fisher WS, Rue LW, Johnson A, Davis L, Brunner RC. Screening for venous thromboembolism in traumatic brain injury: limitations of D-dimer assay. Arch Phys Med Rehabil. 2003;84:285-290.