Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: Results from the CHOPIN trial

Emergency Medicine Journal

Volumn 33, Issue 1, 2016, Pages 23-29

  Marston, Nicholas A ^a   Shah, Kevin S ^a   Mueller, Christian ^b   Neath, Sean Xavier ^a   Christenson, Robert H ^c   McCord, James ^d   Nowak, Richard M ^d   Daniels, Lori B ^a   Hollander, Judd E ^e   Apple, Fred ^f   Nagurney, John ^g   Schreiber, Donald ^h   Defilippi, Christopher ^c   Diercks, Deborah ⁱ   Limkakeng, Alexander ^j   Anand, Inder S ^k   Wu, Alan H B ^l   Jaffe, Allan S ^m   Peacock, W Frank ⁿ   Maisel, Alan S ^a,o  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF MARYLAND   (United States)

^d HENRY FORD HEALTH SYSTEM   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f HENNEPIN COUNTY MEDICAL CENTER   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j DUKE UNIVERSITY   (United States)

^k VETERANS AFFAIRS MEDICAL CENTER   (United States)

^l UNIVERSITY OF CALIFORNIA   (United States)

^m MAYO CLINIC   (United States)

ⁿ BAYLOR COLLEGE OF MEDICINE   (United States)

^o VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COPEPTIN; TROPONIN; GLYCOPEPTIDE;

ACUTE HEART INFARCTION; ADULT; ARTICLE; DIAGNOSTIC PROCEDURE; DISEASE DURATION; FEMALE; FOLLOW UP; HEART DISEASE; HUMAN; INTERMEDIATE RISK PATIENT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; THORAX PAIN; AGED; BLOOD; CHEST PAIN; CLINICAL TRIAL; MIDDLE AGED; MULTICENTER STUDY; MYOCARDIAL INFARCTION; PROCEDURES; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC;

AGED; BIOMARKERS; CHEST PAIN; FEMALE; GLYCOPEPTIDES; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK ASSESSMENT; ROC CURVE; TROPONIN;

EID: 84952871318     PISSN: 14720205     EISSN: 14720213     Source Type: Journal    
DOI: 10.1136/emermed-2015-204692     Document Type: Article

References (19)

1. Bingisser R, Cairns C, Christ M, et al. Cardiac troponin: a critical review of the case for point-of-care testing in the ED. Am J Emerg Med 2012;30:1639-49.
2. Bhuiya F, Pitts S, McCaig L. Emergency department visits for chest pain and abdominal pain: United States 1999-2008. CDC NCHS Data Brief 2010;(43):1-8.
3. ∗trACS): a multicenter registry of patients with suspicion of acute coronary syndromes reported using the standardized reporting guidelines for emergency department chest pain studies. Ann Emerg Med 2006;48:666-77, 677.
4. Elshafei A, Abdalla G, El-Motaal OA, et al. Copeptin: a neuroendocrine biomarker in acute myocardial infarction. Annu Rev Res Biol 2013;3:1040-54.
5. Morgenthaler NG, Struck J, Alonso C, et al. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 2006;52:112-19.
6. Nickel CH, Bingisser R, Morgenthaler NG. The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Med 2012;10:7.
7. Khan SQ, Dhillon OS, O'Brien RJ, et al. C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation 2007;115:2103-10.
8. Gu YL, Voors AA, Zijlstra F, et al. Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction. Clin Res Cardiol 2011;100:1069-76.
9. Maisel A, Mueller C, Neath S, et al. Copeptin helps in the early detection of patients with acute myocardial infarction: primary results from the CHOPIN trial. J Am Coll Cardiol 2013;62:150-60.
10. Möckel M, Searle J, Hamm C, et al. Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): a randomized, controlled clinical process study. Eur Heart J 2015;36:369-76. doi:10.1093/eurheartj/ehu178.
11. Reichlin T, Hochholzer W, Stelzig C, et al. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol 2009;54:60-8.
12. Keller T, Tzikas S, Zeller T, et al. Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol 2012;55:2096-106.
13. O'Malley RG, Bonaca MP, Scirica BM, et al. Prognostic performance of multiple biomarkers in patients with non-ST-segment elevation acute coronary syndrome: analysis from the MERLIN-TIMI 36 trial. J Am Coll Cardiol 2014;63:1644-53.
14. Lipinski MJ, Escarcega RO, D'Ascenzo F, et al. A systemic review and collaborative meta-analysis to determine the incremental value of copeptin for rapid rule-rule out of acute myocardial infarction. Am J Cardiol 2014;113:1581-91.
15. Sebbane M, Lefebvre S, Kuster N, et al. Early rule out of acute myocardial infarction in ED patients: value of combined high-sensitivity cardiac troponin T and ultrasensitive copeptin assays at admission. Am J Emerg Med 2013;31:1302-8.
16. Afzali D, Erren M, Pavenstädt HJ, et al. Impact of copeptin on diagnosis, risk stratification, and intermediate-term prognosis of acute coronary syndromes. Clin Res Cardiol 2013;102:755-63.
17. Raskovalova T, Twerenbold R, Collinson PO, et al. Diagnostic accuracy of combined cardiac troponin and copeptin assessment for early rule-out of myocardial infarction: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care 2014;3:18-27.
18. Jayasinghe R, Narasimhan S, Tran TH, et al. Rapid rule out of myocardial infarction with the use of copeptin as a biomarker for cardiac injury. Intern Med J 2014;44:921-4.
19. Duchenne J, Mestres S, Dublanchet N, et al. Diagnostic accuracy of copeptinsensitivity and specificity in patients with suspected non-ST-elevation myocardial infarction with troponin I below the 99thcentile at presentation. BMJ Open 2014;4:e004449.