Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome

Journal of Physiology

Volumn 594, Issue 1, 2016, Pages 83-97

  Deng, Pan Yue ^a   Klyachko, Vitaly A ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; GLUTAMIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; FMR1 PROTEIN, MOUSE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT;

ACTION POTENTIAL DURATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; EPILEPTIC DISCHARGE; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; FRAGILE X SYNDROME; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL SLICE; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE MODEL; NERVE CELL PLASTICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE SUSCEPTIBILITY; SYNAPTIC TRANSMISSION; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; UPREGULATION;

ACTION POTENTIALS; ANIMALS; CA3 REGION, HIPPOCAMPAL; EXCITATORY POSTSYNAPTIC POTENTIALS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MICE; MICE, INBRED C57BL; PYRAMIDAL CELLS; UP-REGULATION;

EID: 84952864864     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP271031     Document Type: Article

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