Achieving Tolerance with Perforin-Secreting Dendritic Cells

Trends in Molecular Medicine

Volumn 22, Issue 1, 2016, Pages 3-4

  Takenaka, Maisa C ^a   Quintana, Francisco J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; PERFORIN; PORE FORMING CYTOTOXIC PROTEIN;

ADAPTIVE IMMUNITY; AUTOIMMUNE DISEASE; DENDRITIC CELL; EFFECTOR CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; SHORT SURVEY; ANIMAL; AUTOIMMUNITY; CD8+ T LYMPHOCYTE; FEMALE; IMMUNOLOGY; INFLAMMATION; MALE; METABOLIC SYNDROME X;

ANIMALS; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; INFLAMMATION; MALE; METABOLIC SYNDROME X; PORE FORMING CYTOTOXIC PROTEINS;

EID: 84952864251     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.11.008     Document Type: Short Survey

References (10)

1. Quintana F.J., et al. Role and therapeutic value of dendritic cells in central nervous system autoimmunity. Cell Death Differ. 2015, 22:215-224.
2. Hawiger D., et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 2001, 194:769-779.
3. Mascanfroni I.D., et al. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat. Immunol. 2013, 14:1054-1063.
4. Moore K.W., et al. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001, 19:683-765.
5. Quintana F.J., Sherr D.H. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol. Rev. 2013, 65:1148-1161.
6. Zlotnikov-Klionsky Y., et al. Perforin-positive dendritic cells exhibit an immuno-regulatory role in metabolic syndrome and autoimmunity. Immunity 2015, 43:776-787.
7. Zangi L., et al. Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7. Blood 2012, 120:1647-1657.
8. + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 2009, 15:914-920.
9. Cao X., et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007, 27:635-646.
10. Grossman W.J., et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004, 21:589-601.