Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 51, 2015, Pages 15755-15760

  Choi, Miyeon ^a   Lee, Seung Hoon ^a   Wang, Sung Eun ^a   Ko, Seung Yeon ^a   Song, Mihee ^b   Choi, June Seek ^b   Kim, Yong Seok ^a   Duman, Ronald S ^c   Son, Hyeon ^a  

^a Hanyang University   (South Korea)

^b Korea University   (South Korea)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Depression; HDAC; Hippocampus; Ketamine

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE DEACETYLASE 5; INITIATION FACTOR 4E BINDING PROTEIN 1; KETAMINE; MYOCYTE ENHANCER FACTOR 2; PROTEIN KINASE D; ANTIDEPRESSANT AGENT; HDAC5 PROTEIN, RAT; HISTONE DEACETYLASE;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; CELL NUCLEUS; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME PHOSPHORYLATION; ESCAPE BEHAVIOR; FORCED SWIM TEST; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; HIPPOCAMPUS; INTRACELLULAR TRANSPORT; LEARNED HELPLESSNESS TEST; MALE; MUTANT; NONHUMAN; NOVELTY SUPPRESSED FEEDING TEST; NUCLEAR EXPORT; PRIORITY JOURNAL; RAT; SUCROSE PREFERENCE TEST; TRANSCRIPTION REGULATION; ANIMAL; CELL CULTURE; DRUG EFFECTS; METABOLISM; NUCLEOCYTOPLASMIC TRANSPORT; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIDEPRESSIVE AGENTS; CELL NUCLEUS; CELLS, CULTURED; HIPPOCAMPUS; HISTONE DEACETYLASES; KETAMINE; MEF2 TRANSCRIPTION FACTORS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84952701116     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1513913112     Document Type: Article

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