Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity

International Journal of Cardiology

Volumn 203, Issue , 2016, Pages 262-263

  Kok, M G M ^a   Mandolini, C ^a,b   Moerland, P D ^a   De Ronde, M W J ^a   Sondermeijer, B M ^a   Halliani, A ^a   Nieuwland, R ^a   Cipollone, F ^b   Creemers, E E ^a   Meijers, J C M ^a,c   Pinto Sietsma, S J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF CHIETI   (Italy)

^c CENTRAL LABORATORY   (Netherlands)

Author keywords

Antiplatelet agents; Aspirin resistance; miRNA; Prevention

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE RECEPTOR; INDOMETACIN; MICRORNA; MICRORNA 1271; MICRORNA 1537 5P; MICRORNA 19B 1 5P; MICRORNA 548E; MICRORNA 587; RECEPTOR; SIMVASTATIN; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; HYPOCHOLESTEROLEMIC AGENT; MIRN19 MICRORNA, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; RNA;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CENTRIFUGATION; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG SENSITIVITY; DRUG USE; HUMAN; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; TREATMENT DURATION; TREATMENT RESPONSE; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; METABOLISM; MIDDLE AGED; THROMBOCYTE;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICHOLESTEREMIC AGENTS; ASPIRIN; BLOOD PLATELETS; CORONARY ARTERY DISEASE; DRUG RESISTANCE; HUMANS; INDOMETHACIN; MALE; MICRORNAS; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; RNA; SIMVASTATIN;

EID: 84952690563     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2015.10.098     Document Type: Article

References (9)

1. C. Patrono, B. Coller, J.E. Dalen, G.A. FitzGerald, V. Fuster, M. Gent, and et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects Chest 119 2001 39S 63S
2. P.A. Gum, K. Kottke-Marchant, E.D. Poggio, H. Gurm, P.A. Welsh, L. Brooks, and et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease Am. J. Cardiol. 88 2001 230 235
3. J.W. Eikelboom Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events Circulation 105 2002 1650 1655
4. C. Kasmeridis, S. Apostolakis, and G.Y.H. Lip Aspirin and aspirin resistance in coronary artery disease Curr. Opin. Pharmacol. 13 2013 242 250
5. B.M. Sondermeijer, A. Bakker, A. Halliani, M.W.J. de Ronde, A.A. Marquart, A.J. Tijsen, and et al. Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340∗and miRNA624∗ PLoS One 6 2011 e25946
6. GSE59421 GSE59421 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE59421
7. M.G.M. Kok, A. Halliani, P.D. Moerland, J.C.M. Meijers, E.E. Creemers, and S.-J. Pinto-Sietsma Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR FASEB J. 29 2015 3853 3862
8. C. Stratz, T.G. Nührenberg, H. Binder, C.M. Valina, D. Trenk, W. Hochholzer, and et al. Micro-array profiling exhibits remarkable intra-individual stability of human platelet micro-RNA Thromb. Haemost. 107 2012 634 641
9. R. Shi, L. Ge, X. Zhou, W.-J. Ji, R.-Y. Lu, Y.-Y. Zhang, and et al. Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity Thromb. Res. 2013 1 6