Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 51, 2015, Pages 15737-15742

  Arango Lievano, Margarita ^a   Lambert, W Marcus ^b   Bath, Kevin G ^c   Garabedian, Michael J ^b   Chao, Moses V ^d   Jeanneteau, Freddy ^a  

^a UNIV MONTPELLIER   (France)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c BROWN UNIVERSITY   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressant; BDNF; Coincidence detection; Glucocorticoid; Stress

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; FLUOXETINE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PHOSPHATASE 5; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; TROPOMYOSIN-RELATED KINASE-B, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; ENZYME INACTIVATION; IMMUNOHISTOCHEMISTRY; MOLECULAR BIOLOGY; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRESS; ANIMAL; DRUG EFFECTS; FEMALE; MENTAL STRESS; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; FLUOXETINE; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICE; NEURONAL PLASTICITY; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 84952674035     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1509045112     Document Type: Article

References (27)

1. Popoli M, Yan Z, McEwen BS, Sanacora G (2012) The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci 13(1):22-37.
2. Liston C, et al. (2013) Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci 16(6):698-705.
3. Pariante CM (2006) The glucocorticoid receptor: Part of the solution or part of the problem? J Psychopharmacol 20(4, Suppl):79-84.
4. Holsboer F, Ising M (2010) Stress hormone regulation: Biological role and translation into therapy. Annu Rev Psychol 61:81-109, C1-11.
5. Menke A, et al. (2012) Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology 37(6):1455-1464.
6. Webster MJ, Knable MB, O'Grady J, Orthmann J, Weickert CS (2002) Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol Psychiatry 7(9):985-994, 924.
7. McGowan PO, et al. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12(3):342-348.
8. Jeanneteau F, Chao MV (2013) Are BDNF and glucocorticoid activities calibrated? Neuroscience 239:173-195.
9. Revest JM, et al. (2014) BDNF-TrkB signaling through Erk1/2 MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Mol Psychiatry 19(9):1001-1009.
10. Chen DY, Bambah-Mukku D, Pollonini G, Alberini CM (2012) Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation. Nat Neurosci 15(12):1707-1714.
11. Magariños AM, et al. (2011) Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons. Hippocampus 21(3):253-264.
12. Lambert WM, et al. (2013) Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol 33(18):3700-3714.
13. Chen X, et al. (2005) A chemical-genetic approach to studying neurotrophin signaling. Neuron 46(1):13-21.
14. Huang EJ, Reichardt LF (2003) Trk receptors: Roles in neuronal signal transduction. Annu Rev Biochem 72:609-642.
15. Lai KO, et al. (2012) TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci 15(11):1506-1515.
16. Jeanneteau F, Deinhardt K, Miyoshi G, Bennett AM, Chao MV (2010) The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci 13(11):1373-1379.
17. Gray JD, Milner TA, McEwen BS (2013) Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience 239:214-227.
18. Castrén E, Rantamäki T (2010) The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol 70(5):289-297.
19. Galliher-Beckley AJ, Williams JG, Cidlowski JA (2011) Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling. Mol Cell Biol 31(23):4663-4675.
20. Galliher-Beckley AJ, Cidlowski JA (2009) Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and disease. IUBMB Life 61(10):979-986.
21. Wang Z, Chen W, Kono E, Dang T, Garabedian MJ (2007) Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase. Mol Endocrinol 21(3):625-634.
22. Gräff J, Tsai LH (2013) Histone acetylation: Molecular mnemonics on the chromatin. Nat Rev Neurosci 14(2):97-111.
23. Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A (2008) S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 455(7211):411-415.
24. Anacker C, Zunszain PA, Carvalho LA, Pariante CM (2011) The glucocorticoid receptor: Pivot of depression and of antidepressant treatment? Psychoneuroendocrinology 36(3):415-425.
25. Uchida S, et al. (2011) Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron 69(2):359-372.
26. Blugeot A, et al. (2011) Vulnerability to depression: From brain neuroplasticity to identification of biomarkers. J Neurosci 31(36):12889-12899.
27. Jeanneteau F, Garabedian MJ, Chao MV (2008) Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci USA 105(12):4862-4867.