MiR-23b controls TGF-β1 induced airway smooth muscle cell proliferation via TGFβR2/p-Smad3 signals

Molecular Immunology

Volumn 70, Issue , 2016, Pages 84-93

  Chen, Ming ^a   Huang, Linjie ^a   Zhang, Wei ^a,b   Shi, Jianting ^a   Lin, Xiaoling ^a   Lv, Zhiqiang ^a   Liang, Ruiyun ^a   Jiang, Shanping ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b The Second Municipal Hospital of Shenzhen City   (China)

Author keywords

Airway smooth muscle cells; miR 23b; TGF R2 p Smad3

Indexed keywords

MICRORNA; MICRORNA 23B; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; MIRN23B MICRORNA, MOUSE; PROTEIN SERINE THREONINE KINASE; SMAD3 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ADULT; AIRWAY SMOOTH MUSCLE CELL; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; LUCIFERASE ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING; AIRWAY REMODELING; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SMOOTH MUSCLE CELL;

AIRWAY REMODELING; ANIMALS; APOPTOSIS; ASTHMA; BLOTTING, WESTERN; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; MICE; MICE, INBRED BALB C; MICRORNAS; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84952643700     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.12.012     Document Type: Article

References (24)

1. Panettieri R.A., Kotlikoff M.I., Gerthoffer W.T., Hershenson M.B., Woodruff P.G., Hall I.P., Banks-Schlegel S., National Heart Lung, and Blood Institute Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance. Am. J. Respir. Crit. Care Med. 2008, 177(February (3)):248-252.
2. Fernandes D.J., Xu K.F., Stewart A.G. Antiremodelling drugs for the treatment of asthma: requirement for animal models of airway wall remodelling. Clin. Exp. Pharmacol. Physiol. 2001, 28:619-629.
3. Stewart A.G. Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Pulm. Pharmacol. Ther. 2001, 14:255-265.
4. Benayoun L., Druilhe A., Dombret M.C., Aubier M., Pretolani M. Airway structural alterations selectively associated with severe asthma. Am. J. Respir. Crit. Care Med. 2003, 167:1360-1368.
5. Martin J.G., Ramos-Barbon D. Airway smooth muscle growth from the perspective of animal models. Respir. Physiol. Neurobiol. 2003, 137:251-261.
6. Makinde T., Murphy R.F., Agrawal D.K. The regulatory role of TGF-beta in airway remodeling in asthma. Immunol. Cell Biol. 2007, 85:348-356.
7. Brown S.D., Baxter K.M., Stephenson S.T., Esper A.M., Brown L.A., Fitzpatrick A.M. Airway TGF-beta1 and oxidant stress in children with severe asthma: association with airflow limitation. J. Allergy Clin. Immunol. 2012, 396:391-396.
8. Ma J., Wang Q., Fei T., Han J.D., Chen Y.G. MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 2007, 109:987-994.
9. Chen G., Khalil N. TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases. Respir. Res. 2006, 7:2.
10. Ierodiakonou D., Postma D.S., Koppelman G.H., Gerritsen J., Ten H.N., Timens W., Boezen H.M., Vonk J.M. TGF-beta1 polymorphisms and asthma severity, airway inflammation, and remodeling. J. Allergy Clin. Immunol. 2013, 131:582-585.
11. Degryse A.L., Tanjore H., Xu X.C., Polosukhin V.V., Jones B.R., Boomershine C.S., Ortiz C., Sherrill T.P., McMahon F.B., Gleaves L.A., Blackwell T.S., Lawson W.E. TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am. J. Physiol. Lung Cell. Mol. Physiol. 2011, 300(June (6)):L887-L897.
12. Macfarlane L.A., Murphy P.R. MicroRNA: biogenesis, function and role in cancer. Curr. Genomics 2010, 11:537-561.
13. Li W., Liu Z., Chen L., Zhou L., Yao Y. MicroRNA-23b is an independent prognostic marker and suppresses ovarian cancer progression by targeting runt-related transcription factor-2. FEBS Lett. 2014, 588:1608-1615.
14. Pellegrino L., Krell J., Roca-Alonso L., Stebbing J., Castellano L. MicroRNA-23b regulates cellular architecture and impairs motogenic and invasive phenotypes during cancer progression. Bioarchitecture 2013, 3:119-124.
15. Donadelli M., Palmieri M. Roles for microRNA 23b in regulating autophagy and development of pancreatic adenocarcinoma. Gastroenterology 2013, 145:936-938.
16. Ishteiwy R.A., Ward T.M., Dykxhoorn D.M., Burnstein K.L. The microRNA -23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cells. PLoS One 2012, 7:e52106.
17. Au Yeung C.L., Tsang T.Y., Yau P.L., Kwok T.T. Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. Oncogene 2011, 30:2401-2410.
18. Zhang X., Yang J., Zhao J., Zhang P., Huang X. MicroRNA-23b inhibits the proliferation and migration of heat-denatured fibroblasts by targeting Smad3. PLoS One 2015, 10(July (7)):e0131867.
19. Mohamed J.S., Lopez M.A., Boriek A.M. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogensynthase kinase-3β. J. Biol. Chem. 2010, 285(September (38)):29336-29347.
20. Hu R., Pan W., Fedulov A.V., Jester W., Jones M.R., Weiss S.T., Panettieri R.A., Tantisira K., Lu Q. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J. 2014, 28(May (5)):2347-2357.
21. Zhang X., Yang J., Zhao J., Zhang P., Huang X. MicroRNA-23b Inhibits the Proliferation and Migration of Heat-Denatured Fibroblasts by Targeting Smad3. PLoS One 2015, 10(July (8)):e0131867.
22. Begum S., Hayashi M., Ogawa T., Jabboure F.J., Brait M., Izumchenko E., Tabak S., Ahrendt S.A., Westra W.H., Koch W., Sidransky D., Hoque M.O. An integrated genome-wide approach to discover deregulated microRNAs in non-small cell lung cancer: clinical significance of miR-23b-3p deregulation. Sci. Rep. 2015, 5:13236.
23. Mu W., Wang X., Zhang X., Zhu S., Sun D., Ka W., Sung L.A., Yao W. Fluid shear stress upregulates E-Tmod41 via miR-23b-3p and contributes to F-actin Cytoskeleton Remodeling during erythropoiesis. PLoS One 2015, 10(August (8)):e0136607.
24. Iaconetti C., De Rosa S., Polimeni A., Sorrentino S., Gareri C., Carino A., Sabatino J., Colangelo M., Curcio A., Indolfi C. Down-regulation of miR-23b induces phenotypic switching of vascular smooth muscle cells in vitro and in vivo. Cardiovasc. Res. 2015, 107(September (4)):522-533.