Increased activity of frontal and limbic regions to emotional stimuli in children at-risk for anxiety disorders

Psychiatry Research - Neuroimaging

Volumn 233, Issue 1, 2015, Pages 9-17

  Christensen, Rhandi ^a   Van Ameringen, Michael ^a   Hall, Geoffrey ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Anxiety disorders; At risk populations; Functional magnetic resonance imaging; Pediatric anxiety; Social anxiety disorder

Indexed keywords

ANTERIOR CINGULATE; ANXIETY DISORDER; ARTICLE; ATTENTIONAL BIAS; BLOOD OXYGENATION; BOLD SIGNAL; BRAIN REGION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; HYPERACTIVITY; INSULA; MALE; NUCLEAR MAGNETIC RESONANCE SCANNER; PREFRONTAL CORTEX; PRIORITY JOURNAL; RISK FACTOR; SOCIAL PHOBIA; EMOTION; FACIAL EXPRESSION; FRONTAL LOBE; LIMBIC SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; PSYCHOLOGY;

ANXIETY DISORDERS; CHILD; CHILD OF IMPAIRED PARENTS; EMOTIONS; FACIAL EXPRESSION; FEMALE; FRONTAL LOBE; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; PHOTIC STIMULATION;

EID: 84952639280     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2015.04.004     Document Type: Article

References (50)

1. Ball T.M., Sullivan S., Flagan T., Hitchcock C.A., Simmons A., Paulus M.P., Stein M.B. Selective effects of social anxiety, anxiety sensitivity, and negative affectivity on the neural bases of emotional face processing. Neuroimage 2012, 59:1879-1887.
2. Bar-Haim Y., Lamy D., Pergamin L., Bakermans-Kranenburg M.J., Van Ijzendoorn M.H. Threat-related attention bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin 2007, 133:1-24.
3. Beidel D.C., Turner S.M. At risk for anxiety: psychopathology in the offspring of anxious parents. Journal of the American Academy of Child and Adolescent Psychiatry 1997, 36:918-924.
4. Beesdo K., Lau J.Y.F., Guyer A.E., McClure-Tone E.B., Monk C.S., Nelson E.E., Fromm S.J., Goldwin M.A., Wittchen H., Leibenluft E., Ernst M., Pine D.S. Common and distinct amygdala function perturbations in depressed vs. anxious adolescents. Archives of General Psychiatry 2009, 66:275-285.
5. Birbaumer N., Grodd W., Diedrich O., Klose U., Erb M., Lotze M., Schneider F., Weiss U., Flor H. fMRI reveals amygdala activation to human faces in social phobics. NeuroReport 1998, 9:1223-1226.
6. Black D.W., Gaffney G.R., Schlosser S., Gabel J. Children of parents with obsessive compulsive disorder-a 2-year follow-up study. Acta Psychiatrica Scandinavica 2003, 107:305-313.
7. Blair K., Geraci M., Devido J., McCaffrey D., Chen G., Vythilingam M., Ng P., Hollon N., Jones M., Blair J.R., Pine D.S. Neural response to self- and other referential praise and criticism in generalized social phobia. Archives of General Psychiatry 2008, 65:1176-1184.
8. Blair K., Geraci M., Korelitz K., Otero M., Towbin K., Ernst M., Leibenluft E., Blair R. The pathology of social phobia is independent of developmental changes in face processing. American Journal of Psychiatry 2011, 168:1202-1209.
9. Blair K.S., Geraci M., Smith B.W., Hollon N., DeVido J., Otero M., Blair J.R., Pine D.S. Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder and comorbid generalized social phobia/generalized anxiety disorder. Biological Psychiatry 2012, 72:476-482.
10. Breiter H.C., Etcoff N.L., Whalen P.J., Kennedy W.A., Rauch S.L., Buckner R.L., Strauss M.M., Hyman S.E., Rosen B.R. Response and habituation of the human amygdala during visual processing of facial expression. Neuron 1996, 17:875-887.
11. Capps L., Signman M., Sena R., Henker B. Fear, anxiety and perceived control in children of agoraphobic parents. Journal of Child Psychology and Psychiatry 1996, 37:445-452.
12. Clark D.M., Wells A. A Cognitive Model of Social Phobia 1995, Guilford Press, New York.
13. Clark D.M., McManus F. Information processing in social phobia. Biological Psychiatry 2002, 51:92-100.
14. Ekman P., Friesen W.V. Pictures of Facial Affect. San Francisco, CA 1976, University of California.
15. Esteves F., Ohman A. Masking the face: recognition of emotional facial expressions as a function of the parameters of backward masking. Scandinavian Journal of Psychology 1993, 34:1-18.
16. Evans K.C., Wright C.I., Wedig M.M., Gold A.L., Pollack M.H., Rauch S.L. A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder. Depression and Anxiety 2008, 25:496-505.
17. Genovese C.R., Lazar N.A., Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002, 15:870-878.
18. Goldin P.R., Manber T., Hakimi S., Canli T., Gross J.J. The neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Archives of General Psychiatry 2009, 66:170-180.
19. Guyer A.E., Lau J.Y.F., McClure E.B., Parrish J., Shiffrin N.D., Reynolds R.C., Chen G., Blair J.R., Leibenluft E., Fox N.A., Ernst M., Pine D.S., Nelson E.E. Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. Archives of General Psychiatry 2008, 65:1303-1312.
20. Hardee J.E., Benson B.E., Bar-Haim Y., Mogg K., Bradley B.P., Chen.G., Britton J.C., Ernst M., Fox N.A., Pine D.S., Pérez-Edgar K. Patterns of neural connectivity during an attention bias task moderate associations between early childhood temperament and internalizing symptoms in young adulthood. Biological Psychiatry 2013, 74:273-279.
21. Hariri A.R., Bookheimer S.Y., Mazziotta J.C. Modulating emotional responses: effects of a neocortical network on the limbic system. NeuroReport 2000, 11:43-48.
22. Hollingshead A.A. Four-Factor Index of Social Status 1975, Unpublished manuscript, Yale University, New Haven, CT.
23. Lau J.Y.F., Goldman D., Buzas B., Fromm S.J., Guyer A.E., Hodgkinson C., Monk C.S., Nelson E.E., Shen P., Pine D., Ernst M. Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biological Psychiatry 2009, 65:349-355.
24. Lundqvist D., Flykt A., Ohman A. Karolinska Directed Emotional Faces 1998, Karolinska Institute, Stockholm, Sweden.
25. MacLeod C., Mathews A., Tata P. Attention bias in emotional disorders. Journal of Abnormal Psychology 1986, 95:15-20.
26. Mancini C., Van Ameringen M., Szatmari P., Fugere C., Boyle M. A high-risk pilot study of the children of adults with social phobia. Journal of the American Academy of Child and Adolescent Psychiatry 1996, 11:1511-1517.
27. McClure B., Monk C.S., Nelson E.E., Parrish J.M., Adler A., Blair R.J., Fromm S., Charney D.S., Leibenluft E., Ernst M., Pine D.S. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Archives of General Psychiatry 2007, 64:97-106.
28. Merikangas K.R., Dierker L.C. Psycholopathology among offspring of parents with substance abuse and/or anxiety disorders: a high risk study. Journal of Child Psychology and Psychiatry 1998, 39:711-720.
29. Merikangas K.R. Vulnerability factors for anxiety disorders in children and adolescents. Child and Adolescent Psychiatric Clinics of North America 2005, 14:649-679.
30. Mogg K., Bradley B.P. Selective orienting of attention to masked threat faces in social anxiety. Behaviour Research and Therapy 2002, 40:1403-1414.
31. Monk C.S., Nelson E.E., McClure E.B., Mogg K., Bradley B.P., Leibenluft E., Blair R.J., Chen G., Charney D.S., Ernst M., Pine D.S. Ventrolateral prefrontal cortex activation and attention bias in response to angry faces in adolescents with generalized anxiety disorder. American Journal of Psychiatry 2006, 16:1091-1097.
32. Monk C.S., Telzer E.H., Mogg K., Bradley B.P., Mai X., Louro H.M., Chen G., McClure E.B., Ernst M., Pine D.S. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Archives of General Psychiatry 2008, 65:568-576.
33. Monk C.S., Klein R.G., Telzer E.H., Schroth E.A., Mannuzza S., Moulton J.L., Guardino M., Masten C.L., McClure-Tone E.B., Fromm S., Blair R.J., Pine D.S., Ernst M. Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. American Journal of Psychiatry 2008, 165:90-98.
34. Perez-Edgar K., Hardee J.E., Guyer A.E., Benson B.E., Nelson E.E., Gorodetsky E., Goldman D., Fox N.A., Pine D.S., Ernst M. DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety. Social Cognitive and Affective Neuroscience 2014, 9:445-453.
35. Phan K.L., Fitzgerald D.A., Nathan P.J., Tancer M.E. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biological Psychiatry 2006, 59:424-429.
36. Puliafico A.C., Kendall P.C. Threat-related attention bias in anxious youth: a review. Clinical Child and Family Psychology Review 2006, 9:162-180.
37. Rolls E.T., Tovee M.J. Processing speed in the cerebral cortex and the neurophysiology of visual masking. Proceedings of the Royal Society of London 1994, 257:9-15.
38. Rosenbaum J.F., Biderman J., Gersten M., Hirshfeld D.R., Meminger S.R., Herman J.B., Kagan J., Reznick J.S., Snidman N. Behavioral inhibition in children of parents with panic disorder and agoraphobia. A controlled study. Archives of General Psychiatry 1988, 45:463-470.
39. Rosenbaum J.F., Biderman J., Hirshfeld D.R., Bolduc E.A., Faraone S.V., Kagan J., Snidman N., Reznick J.S. Further evidence of an association between behavioral inhibition and anxiety disorders: results from a family study of children from a non-clinical sample. Journal of Psychiatric Research 1991, 25:49-65.
40. Roy A.K., Benson B.E., Degan K.A., Perez-Edgar K., Pine D.S., Fox N.A., Ernst M. Alterations in amygdala functional connectivity reflect early temperament. Biological Psychiatry 2014, 103:248-254.
41. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Herqueta T., Baker R., Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and IC-10. Journal of Clinical Psychiatry 1998, 59:34-57.
42. Silverman W.K., Nelles W.B. The anxiety disorders interview schedule for children. Journal of the American Academy of Child and Adolescent Psychiatry 1988, 27:772-778.
43. Smoller J.W., Gardner-Schuster E., Covino J. The genetic basis of panic and phobic anxiety disorders. American Journal of Medical Genetics 2008, 148:118-126.
44. Stein M.B., Goldin P.R., Sareem J., Zorrila L.T., Brown G.G. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry 2002, 59:1027-1034.
45. Straube T., Kolassa I., Glaure M., Mentzel H., Miltner W. Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study. Biological Psychiatry 2004, 56:921-930.
46. Talairach J., Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain 1988, Thieme Medical Publishers, New York.
47. Thomas K.M., Drevets W.C., Dahl R.E., Ryan N.D., Birmaher B., Eccard C.H., Axelson D., Whalen P.J., Casey B.J. Amygdala response to fearful faces in anxious and depressed children. Archives of General Psychiatry 2001, 58:1057-1063.
48. Whalen P.J., Rauch S.L., Etcoff N.L., McInerney S.C., Lee M.B., Jenike M.A. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. Journal of Neuroscience 1998, 18:411-418.
49. Wright C.I., Martis B., Shin L.M., Fischer H., Rauch S. Enhanced amygdala responses to emotional versus neutral schematic facial expressions. Neuroreport 2002, 13:785-790.
50. Wright C.I., Martis B., McMullin K., Shin L.M., Rauch S.L. Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. Biological Psychiatry 2003, 54:1067-1076.