Is carbamazepine a human teratogen?

Journal of Clinical Neuroscience

Volumn 23, Issue , 2016, Pages 34-37

  Vajda, F J E ^a   O'Brien, T J ^a   Graham, J ^a   Lander, C M ^b   Eadie, M J ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antiepileptic drugs; Carbamazepine; Foetal malformation; Teratogenesis

Indexed keywords

CARBAMAZEPINE; ETIRACETAM; TOPIRAMATE; VALPROIC ACID; ANTICONVULSIVE AGENT; PIRACETAM; TERATOGENIC AGENT;

DRUG EXPOSURE; EPILEPSY; FETUS MALFORMATION; FETUS OUTCOME; HUMAN; INTERVIEW; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; REVIEW; RISK FACTOR; TERATOGENICITY; ABNORMALITIES, DRUG-INDUCED; ADULT; ANALOGS AND DERIVATIVES; AUSTRALIA; DRUG EFFECTS; FEMALE; FETUS; PREGNANCY COMPLICATIONS; REGISTER; RISK;

ABNORMALITIES, DRUG-INDUCED; ADULT; ANTICONVULSANTS; AUSTRALIA; CARBAMAZEPINE; EPILEPSY; FEMALE; FETUS; HUMANS; PIRACETAM; PREGNANCY; PREGNANCY COMPLICATIONS; REGISTRIES; RISK; TERATOGENS; VALPROIC ACID;

EID: 84952638348     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2015.07.011     Document Type: Review

References (27)

1. B.J. Wlodarczyk, A.M. Palacios, T.M. George, and et al. Antiepileptic drugs and pregnancy outcomes Am J Med Genet A 158A 2011 2071 2090
2. F.J. Vajda, T. O'Brien, A. Hitchcock, and et al. The Australian antiepileptic drug in pregnancy register: aspects of data collection and analysis J Clin Neurosci 14 2007 936 942
3. F.J. Vajda, S. Hollingworth, J. Graham, and et al. Changing patterns of antiepileptic drug use in pregnant Australian women Acta Neurol Scandinav 121 2010 89 93
4. F.J. Vajda, T.J. O'Brien, J. Graham, and et al. The Australian register of antiepileptic drugs in pregnancy - changes with time in its epileptic population J Clin Neurosci 21 2014 1478 1482
5. M. Riley, and J. Halliday Birth Defects in Victoria 1983-1998, Perinatal Data Collection Unit, 2008 2000 Victorian Government Department of Human Services Melbourne
6. E.B. Samrén, C.M. van Duijn, G.C. Christiaens, and et al. Antiepileptic drug regimens and major congenital abnormalities in the offspring Ann Neurol 46 1999 739 746
7. J. Morrow, A. Russell, E. Guthrie, and et al. Malformation risk of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register J Neurol Neurosurg Psychiatry 77 2006 193 198
8. E. Campbell, E. Devenney, J. Morrow, and et al. Recurrence risk of congenital malformations in infants exposed to antiepileptic drugs in utero Epilepsia 54 2013 165 171
9. F.J. Vajda, T.J. O'Brien, C.M. Lander, and et al. Teratogenesis in repeated pregnancies in antiepileptic drug-treated women Epilepsia 54 2013 181 186
10. K. Wide, B. Winlladh, and B. Källén Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study Acta Pediatr 93 2004 174 176
11. E. Perucca Birth defects after prenatal exposure to antiepileptic drugs Lancet Neurol 4 2005 781 786
12. T. Tomson, D. Battino, E. Bonizzoni, and et al. Dose-dependent risk of malformation with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry Lancet Neurol 10 2011 609 617
13. E. Mahwinney, J. Craig, J. Morrow, and et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers Neurology 80 2013 400 405
14. G. Veiby, A.K. Daltveit, B.A. Engelsen, and et al. Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy J Neurol 261 2014 579 588
15. S.A. Chaudhry, G. Jong, and G. Koren The fetal safety of levetiracetam Reprod Toxicol 46 2014 40 45
16. S. Kaneko, D. Battino, E. Andermann, and et al. Congenital malformations due to antiepileptic drugs Epilepsy Res 33 1999 145 158
17. L.B. Holmes, G.A. Harvey, B.A. Coull, and et al. The teratogenicity of anticonvulsant drugs N Eng J Med 344 2001 1132 1138
18. O. Diav-Citrin, S. Shectman, J. Arnon, and et al. Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies Neurology 57 2001 321 324
19. E. Kaaja, R. Kaaja, and V. Hiilesmaa Major malformations in offspring of women with epilepsy Neurology 60 2003 575 579
20. M. Artama, A. Auvinen, T. Raudaskoski, and et al. Antiepileptic drug use of women with epilepsy and congenital malformations in the offspring Neurology 64 2005 1874 1878
21. S. Hernandez-Diaz, C.R. Smith, and D. Wyzszynski Risk of major malformations among infants exposed to carbamazepine during pregnancy Birth Defects Res (Part A) 79 2007 357
22. G. Mawer, M. Briggs, G.A. Baker, and et al. Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study Seizure 19 2010 112 119
23. L.B. Holmes, R. Mittendorf, A. Shen, and et al. Fetal effects of anticonvulsant polytherapies Arch Neurol 68 2011 1275 1281
24. E.B. Samrén, C.M. van Duijn, S. Koch, and et al. Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy Epilepsia 38 1997 981 990
25. S. Matalon, S. Schectman, G. Goldzweig, and et al. The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures Reprod Toxicol 16 2002 9 17
26. K. Meador, M.W. Reynolds, S. Crean, and et al. Pregnancy outcomes in women with epilepsy: a systematic review and analysis of published pregnancy registers and cohorts Epilepsy Res 81 2008 1 13
27. J. Jentink, H. Dolk, M.A. Loane, and et al. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study Br Med J 341 2010 c6581