-
1
-
-
0018101547
-
Rapamycin (AY-22, 989), a new antifungal antibiotic III
-
Baker H, Sidorowicz A, Sehgal SN, et al. Rapamycin (AY-22, 989), a new antifungal antibiotic III. In vitro and in vivo evaluation. J Antibiot (Tokyo) 1978;31:539-545.
-
(1978)
In vitro and in vivo evaluation. J Antibiot (Tokyo)
, vol.31
, pp. 539-545
-
-
Baker, H.1
Sidorowicz, A.2
Sehgal, S.N.3
-
2
-
-
0346362997
-
Rapamycins: Mechanism of action and cellular resistance
-
Huang S, Bjornsti MA, Houghton PJ. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2003;2:222-232.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 222-232
-
-
Huang, S.1
Bjornsti, M.A.2
Houghton, P.J.3
-
3
-
-
17144373720
-
Inhibitors of the mammalian target of rapamycin
-
Dancey JE. Inhibitors of the mammalian target of rapamycin. Expert Opin Investig Drugs 2005;14:313-328.
-
(2005)
Expert Opin Investig Drugs
, vol.14
, pp. 313-328
-
-
Dancey, J.E.1
-
4
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
Guba M, Von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8:128-135.
-
(2002)
Nat Med
, vol.8
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
-
5
-
-
84862528335
-
Targeting mTOR pathways in human malignancies
-
Fasolo A, Sessa C. Targeting mTOR pathways in human malignancies. Curr Pharm Des 2012;18:2766-2777.
-
(2012)
Curr Pharm Des
, vol.18
, pp. 2766-2777
-
-
Fasolo, A.1
Sessa, C.2
-
6
-
-
84904814066
-
Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: An emerging treatment strategy for squamous cell lung carcinoma
-
Beck JT, Ismail A, Tolomeo C. Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung carcinoma. Cancer Treat Rev 2014;40:980-989.
-
(2014)
Cancer Treat Rev
, vol.40
, pp. 980-989
-
-
Beck, J.T.1
Ismail, A.2
Tolomeo, C.3
-
7
-
-
84903891089
-
Targeting PI3K/ AKT/mTOR pathway in non small cell lung cancer
-
Fumarola C, Bonelli MA, Petronini PG, et al. Targeting PI3K/ AKT/mTOR pathway in non small cell lung cancer. Biochem Pharmacol 2014;90:197-207.
-
(2014)
Biochem Pharmacol
, vol.90
, pp. 197-207
-
-
Fumarola, C.1
Bonelli, M.A.2
Petronini, P.G.3
-
8
-
-
84906939925
-
Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours
-
Martin-Liberal J, Gil-Martin M, Sáinz-Jaspeado M, et al. Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours. Br J Cancer 2014;111:858-865.
-
(2014)
Br J Cancer
, vol.111
, pp. 858-865
-
-
Martin-Liberal, J.1
Gil-Martin, M.2
Sáinz-Jaspeado, M.3
-
9
-
-
49749093760
-
Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs
-
Gordon IK, Ye F, Kent MS. Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs. Am J Vet Res 2008;69:1079-1084.
-
(2008)
Am J Vet Res
, vol.69
, pp. 1079-1084
-
-
Gordon, I.K.1
Ye, F.2
Kent, M.S.3
-
10
-
-
84868618609
-
Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signaling pathway in canine hemangiomas and hemangiosarcomas
-
Murai A, Asa SA, Kodama A, et al. Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signaling pathway in canine hemangiomas and hemangiosarcomas. J Comp Pathol 2012;147:430-440.
-
(2012)
J Comp Pathol
, vol.147
, pp. 430-440
-
-
Murai, A.1
Asa, S.A.2
Kodama, A.3
-
11
-
-
84864202400
-
Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
-
Accessed January 23, 2015
-
Murai A, Asa SA, Kodama A, et al. Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines. BMC Vet Res [serial online] 2012;8:128. Available at: www.biomedcentral.com/1746-6148/8/128. Accessed January 23, 2015.
-
(2012)
BMC Vet Res [serial online]
, vol.8
, pp. 128
-
-
Murai, A.1
Asa, S.A.2
Kodama, A.3
-
12
-
-
60749124741
-
Activation of the AKT and mammalian target of rapamycin pathways and the inhibitory effects of rapamycin on those pathways in canine malignant melanoma cell lines
-
Kent MS, Collins CJ, Ye F. Activation of the AKT and mammalian target of rapamycin pathways and the inhibitory effects of rapamycin on those pathways in canine malignant melanoma cell lines. Am J Vet Res 2009;70:263-269.
-
(2009)
Am J Vet Res
, vol.70
, pp. 263-269
-
-
Kent, M.S.1
Collins, C.J.2
Ye, F.3
-
13
-
-
0025073524
-
Rapamycin in experimental renal allografts in dogs and pigs
-
Collier DS, Calne R, Thiru S, et al. Rapamycin in experimental renal allografts in dogs and pigs. Transplant Proc 1990;22:1674-1675.
-
(1990)
Transplant Proc
, vol.22
, pp. 1674-1675
-
-
Collier, D.S.1
Calne, R.2
Thiru, S.3
-
14
-
-
0027530260
-
Low-dose rapamycin potentiates the effects of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model
-
Knight R, Ferraresso M, Serino F, et al. Low-dose rapamycin potentiates the effects of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model. Transplantation 1993;55:947-949.
-
(1993)
Transplantation
, vol.55
, pp. 947-949
-
-
Knight, R.1
Ferraresso, M.2
Serino, F.3
-
15
-
-
0029587330
-
Effect of rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine
-
Hartner WC, Van der Werf WJ, Lodge PA, et al. Effect of rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine. Transplantation 1995;60:1347-1350.
-
(1995)
Transplantation
, vol.60
, pp. 1347-1350
-
-
Hartner, W.C.1
Van der Werf, W.J.2
Lodge, P.A.3
-
16
-
-
84901585492
-
Correction of glycogen storage disease type III with rapamycin in a canine model
-
Yi H, Brooks ED, Thurberg BL. Correction of glycogen storage disease type III with rapamycin in a canine model. J Mol Med 2014;92:641-650.
-
(2014)
J Mol Med
, vol.92
, pp. 641-650
-
-
Yi, H.1
Brooks, E.D.2
Thurberg, B.L.3
-
17
-
-
77956205777
-
Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: A comparative oncology study in dogs
-
Accessed January 23, 2015
-
Paoloni MC, Mazcko C, Fox E, et al. Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs. PLoS ONE [serial online] 2010;5:e11013. Available at: journals.plos.org/plosone/ article?id=10.1371/journal.pone.0011013. Accessed January 23, 2015.
-
(2010)
PLoS ONE [serial online]
, vol.5
-
-
Paoloni, M.C.1
Mazcko, C.2
Fox, E.3
-
18
-
-
72049086018
-
Development and validation of a semi-automated assay for the highly sensitive quantification of Biolumus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry
-
Clavijo C, Strom T, Moll V, et al. Development and validation of a semi-automated assay for the highly sensitive quantification of Biolumus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:3506-3514.
-
(2009)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.877
, pp. 3506-3514
-
-
Clavijo, C.1
Strom, T.2
Moll, V.3
-
19
-
-
0036238215
-
Simultaneous quantification of sirolimus, everolimus, tacrolimus, and cyclosporine by liquid chromatography-mass spectrometry (LC-MS)
-
Deters M, Kirchner G, Resch K, et al. Simultaneous quantification of sirolimus, everolimus, tacrolimus, and cyclosporine by liquid chromatography-mass spectrometry (LC-MS). Clin Chem Lab Med 2002;40:285-292.
-
(2002)
Clin Chem Lab Med
, vol.40
, pp. 285-292
-
-
Deters, M.1
Kirchner, G.2
Resch, K.3
-
20
-
-
34247843033
-
Key elements of bioanalytical method validation for small molecules
-
Bansel S, DeStefano A. Key elements of bioanalytical method validation for small molecules. AAPS J 2007;9:E109-E114.
-
(2007)
AAPS J
, vol.9
, pp. E109-E114
-
-
Bansel, S.1
DeStefano, A.2
-
21
-
-
0031863355
-
Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine
-
Lampen A, Zhang Y, Hackbarth I, et al. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther 1998;285:1104-1112.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 1104-1112
-
-
Lampen, A.1
Zhang, Y.2
Hackbarth, I.3
-
22
-
-
77952567559
-
Multiple peaking phenomena in pharmacokinetic disposition
-
Davis NM, Takemoto JK, Brocks DR, et al. Multiple peaking phenomena in pharmacokinetic disposition. Clin Pharmacokinet 2010;49:351-377.
-
(2010)
Clin Pharmacokinet
, vol.49
, pp. 351-377
-
-
Davis, N.M.1
Takemoto, J.K.2
Brocks, D.R.3
-
23
-
-
21644469886
-
Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
-
Guba M, Koehl GE, Neppl E, et al. Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer. Transpl Int 2005;18:89-94.
-
(2005)
Transpl Int
, vol.18
, pp. 89-94
-
-
Guba, M.1
Koehl, G.E.2
Neppl, E.3
-
24
-
-
0033867011
-
Stability of sirolimus (rapamycin) in whole blood
-
Salm P, Tresillian MJ, Taylor PJ, et al. Stability of sirolimus (rapamycin) in whole blood. Ther Drug Monit 2000;22:423-426.
-
(2000)
Ther Drug Monit
, vol.22
, pp. 423-426
-
-
Salm, P.1
Tresillian, M.J.2
Taylor, P.J.3
-
25
-
-
47249131616
-
Stability of sirolimus and everolimus measured by immunoassay techniques in whole blood samples from kidney transplant patients
-
Capone D, Gentile A, Polichetti G, et al. Stability of sirolimus and everolimus measured by immunoassay techniques in whole blood samples from kidney transplant patients. Int J Immunopathol Pharmacol 2008;21:297-307.
-
(2008)
Int J Immunopathol Pharmacol
, vol.21
, pp. 297-307
-
-
Capone, D.1
Gentile, A.2
Polichetti, G.3
-
26
-
-
0034075822
-
Therapeutic drug monitoring of sirolimus: Correlations with efficacy and toxicity
-
Kahan BD, Napoli KL, Kelly PA, et al. Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity. Clin Transplant 2000;14:97-109.
-
(2000)
Clin Transplant
, vol.14
, pp. 97-109
-
-
Kahan, B.D.1
Napoli, K.L.2
Kelly, P.A.3
|