메뉴 건너뛰기




Volumn 77, Issue 1, 2016, Pages 65-71

Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN;

EID: 84952333992     PISSN: 00029645     EISSN: 19435681     Source Type: Journal    
DOI: 10.2460/ajvr.77.1.65     Document Type: Article
Times cited : (16)

References (26)
  • 2
    • 0346362997 scopus 로고    scopus 로고
    • Rapamycins: Mechanism of action and cellular resistance
    • Huang S, Bjornsti MA, Houghton PJ. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2003;2:222-232.
    • (2003) Cancer Biol Ther , vol.2 , pp. 222-232
    • Huang, S.1    Bjornsti, M.A.2    Houghton, P.J.3
  • 3
    • 17144373720 scopus 로고    scopus 로고
    • Inhibitors of the mammalian target of rapamycin
    • Dancey JE. Inhibitors of the mammalian target of rapamycin. Expert Opin Investig Drugs 2005;14:313-328.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 313-328
    • Dancey, J.E.1
  • 4
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, Von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8:128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3
  • 5
    • 84862528335 scopus 로고    scopus 로고
    • Targeting mTOR pathways in human malignancies
    • Fasolo A, Sessa C. Targeting mTOR pathways in human malignancies. Curr Pharm Des 2012;18:2766-2777.
    • (2012) Curr Pharm Des , vol.18 , pp. 2766-2777
    • Fasolo, A.1    Sessa, C.2
  • 6
    • 84904814066 scopus 로고    scopus 로고
    • Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: An emerging treatment strategy for squamous cell lung carcinoma
    • Beck JT, Ismail A, Tolomeo C. Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung carcinoma. Cancer Treat Rev 2014;40:980-989.
    • (2014) Cancer Treat Rev , vol.40 , pp. 980-989
    • Beck, J.T.1    Ismail, A.2    Tolomeo, C.3
  • 7
    • 84903891089 scopus 로고    scopus 로고
    • Targeting PI3K/ AKT/mTOR pathway in non small cell lung cancer
    • Fumarola C, Bonelli MA, Petronini PG, et al. Targeting PI3K/ AKT/mTOR pathway in non small cell lung cancer. Biochem Pharmacol 2014;90:197-207.
    • (2014) Biochem Pharmacol , vol.90 , pp. 197-207
    • Fumarola, C.1    Bonelli, M.A.2    Petronini, P.G.3
  • 8
    • 84906939925 scopus 로고    scopus 로고
    • Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours
    • Martin-Liberal J, Gil-Martin M, Sáinz-Jaspeado M, et al. Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours. Br J Cancer 2014;111:858-865.
    • (2014) Br J Cancer , vol.111 , pp. 858-865
    • Martin-Liberal, J.1    Gil-Martin, M.2    Sáinz-Jaspeado, M.3
  • 9
    • 49749093760 scopus 로고    scopus 로고
    • Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs
    • Gordon IK, Ye F, Kent MS. Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs. Am J Vet Res 2008;69:1079-1084.
    • (2008) Am J Vet Res , vol.69 , pp. 1079-1084
    • Gordon, I.K.1    Ye, F.2    Kent, M.S.3
  • 10
    • 84868618609 scopus 로고    scopus 로고
    • Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signaling pathway in canine hemangiomas and hemangiosarcomas
    • Murai A, Asa SA, Kodama A, et al. Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signaling pathway in canine hemangiomas and hemangiosarcomas. J Comp Pathol 2012;147:430-440.
    • (2012) J Comp Pathol , vol.147 , pp. 430-440
    • Murai, A.1    Asa, S.A.2    Kodama, A.3
  • 11
    • 84864202400 scopus 로고    scopus 로고
    • Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
    • Accessed January 23, 2015
    • Murai A, Asa SA, Kodama A, et al. Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines. BMC Vet Res [serial online] 2012;8:128. Available at: www.biomedcentral.com/1746-6148/8/128. Accessed January 23, 2015.
    • (2012) BMC Vet Res [serial online] , vol.8 , pp. 128
    • Murai, A.1    Asa, S.A.2    Kodama, A.3
  • 12
    • 60749124741 scopus 로고    scopus 로고
    • Activation of the AKT and mammalian target of rapamycin pathways and the inhibitory effects of rapamycin on those pathways in canine malignant melanoma cell lines
    • Kent MS, Collins CJ, Ye F. Activation of the AKT and mammalian target of rapamycin pathways and the inhibitory effects of rapamycin on those pathways in canine malignant melanoma cell lines. Am J Vet Res 2009;70:263-269.
    • (2009) Am J Vet Res , vol.70 , pp. 263-269
    • Kent, M.S.1    Collins, C.J.2    Ye, F.3
  • 13
    • 0025073524 scopus 로고
    • Rapamycin in experimental renal allografts in dogs and pigs
    • Collier DS, Calne R, Thiru S, et al. Rapamycin in experimental renal allografts in dogs and pigs. Transplant Proc 1990;22:1674-1675.
    • (1990) Transplant Proc , vol.22 , pp. 1674-1675
    • Collier, D.S.1    Calne, R.2    Thiru, S.3
  • 14
    • 0027530260 scopus 로고
    • Low-dose rapamycin potentiates the effects of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model
    • Knight R, Ferraresso M, Serino F, et al. Low-dose rapamycin potentiates the effects of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model. Transplantation 1993;55:947-949.
    • (1993) Transplantation , vol.55 , pp. 947-949
    • Knight, R.1    Ferraresso, M.2    Serino, F.3
  • 15
    • 0029587330 scopus 로고
    • Effect of rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine
    • Hartner WC, Van der Werf WJ, Lodge PA, et al. Effect of rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine. Transplantation 1995;60:1347-1350.
    • (1995) Transplantation , vol.60 , pp. 1347-1350
    • Hartner, W.C.1    Van der Werf, W.J.2    Lodge, P.A.3
  • 16
    • 84901585492 scopus 로고    scopus 로고
    • Correction of glycogen storage disease type III with rapamycin in a canine model
    • Yi H, Brooks ED, Thurberg BL. Correction of glycogen storage disease type III with rapamycin in a canine model. J Mol Med 2014;92:641-650.
    • (2014) J Mol Med , vol.92 , pp. 641-650
    • Yi, H.1    Brooks, E.D.2    Thurberg, B.L.3
  • 17
    • 77956205777 scopus 로고    scopus 로고
    • Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: A comparative oncology study in dogs
    • Accessed January 23, 2015
    • Paoloni MC, Mazcko C, Fox E, et al. Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs. PLoS ONE [serial online] 2010;5:e11013. Available at: journals.plos.org/plosone/ article?id=10.1371/journal.pone.0011013. Accessed January 23, 2015.
    • (2010) PLoS ONE [serial online] , vol.5
    • Paoloni, M.C.1    Mazcko, C.2    Fox, E.3
  • 18
    • 72049086018 scopus 로고    scopus 로고
    • Development and validation of a semi-automated assay for the highly sensitive quantification of Biolumus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry
    • Clavijo C, Strom T, Moll V, et al. Development and validation of a semi-automated assay for the highly sensitive quantification of Biolumus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:3506-3514.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , pp. 3506-3514
    • Clavijo, C.1    Strom, T.2    Moll, V.3
  • 19
    • 0036238215 scopus 로고    scopus 로고
    • Simultaneous quantification of sirolimus, everolimus, tacrolimus, and cyclosporine by liquid chromatography-mass spectrometry (LC-MS)
    • Deters M, Kirchner G, Resch K, et al. Simultaneous quantification of sirolimus, everolimus, tacrolimus, and cyclosporine by liquid chromatography-mass spectrometry (LC-MS). Clin Chem Lab Med 2002;40:285-292.
    • (2002) Clin Chem Lab Med , vol.40 , pp. 285-292
    • Deters, M.1    Kirchner, G.2    Resch, K.3
  • 20
    • 34247843033 scopus 로고    scopus 로고
    • Key elements of bioanalytical method validation for small molecules
    • Bansel S, DeStefano A. Key elements of bioanalytical method validation for small molecules. AAPS J 2007;9:E109-E114.
    • (2007) AAPS J , vol.9 , pp. E109-E114
    • Bansel, S.1    DeStefano, A.2
  • 21
    • 0031863355 scopus 로고    scopus 로고
    • Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine
    • Lampen A, Zhang Y, Hackbarth I, et al. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther 1998;285:1104-1112.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 1104-1112
    • Lampen, A.1    Zhang, Y.2    Hackbarth, I.3
  • 22
    • 77952567559 scopus 로고    scopus 로고
    • Multiple peaking phenomena in pharmacokinetic disposition
    • Davis NM, Takemoto JK, Brocks DR, et al. Multiple peaking phenomena in pharmacokinetic disposition. Clin Pharmacokinet 2010;49:351-377.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 351-377
    • Davis, N.M.1    Takemoto, J.K.2    Brocks, D.R.3
  • 23
    • 21644469886 scopus 로고    scopus 로고
    • Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
    • Guba M, Koehl GE, Neppl E, et al. Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer. Transpl Int 2005;18:89-94.
    • (2005) Transpl Int , vol.18 , pp. 89-94
    • Guba, M.1    Koehl, G.E.2    Neppl, E.3
  • 24
    • 0033867011 scopus 로고    scopus 로고
    • Stability of sirolimus (rapamycin) in whole blood
    • Salm P, Tresillian MJ, Taylor PJ, et al. Stability of sirolimus (rapamycin) in whole blood. Ther Drug Monit 2000;22:423-426.
    • (2000) Ther Drug Monit , vol.22 , pp. 423-426
    • Salm, P.1    Tresillian, M.J.2    Taylor, P.J.3
  • 25
    • 47249131616 scopus 로고    scopus 로고
    • Stability of sirolimus and everolimus measured by immunoassay techniques in whole blood samples from kidney transplant patients
    • Capone D, Gentile A, Polichetti G, et al. Stability of sirolimus and everolimus measured by immunoassay techniques in whole blood samples from kidney transplant patients. Int J Immunopathol Pharmacol 2008;21:297-307.
    • (2008) Int J Immunopathol Pharmacol , vol.21 , pp. 297-307
    • Capone, D.1    Gentile, A.2    Polichetti, G.3
  • 26
    • 0034075822 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of sirolimus: Correlations with efficacy and toxicity
    • Kahan BD, Napoli KL, Kelly PA, et al. Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity. Clin Transplant 2000;14:97-109.
    • (2000) Clin Transplant , vol.14 , pp. 97-109
    • Kahan, B.D.1    Napoli, K.L.2    Kelly, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.