No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception

Clinical Infectious Diseases

Volumn 61, Issue 11, 2015, Pages 1715-1725

  Mandelbrot, Laurent ^a,b,e,h   Tubiana, Roland ^i,j   Le Chenadec, Jerome ^b   Dollfus, Catherine ^k   Faye, Albert ^e,l   Pannier, Emmanuelle ^h,m   Matheron, Sophie ^e,n   Khuong, Marie Aude ^q   Garrait, Valerie ^r   Reliquet, Veronique ^s   Devidas, Alain ^t   Berrebi, Alain ^u   Allisy, Christine ^v   Elleau, Christophe ^w   Arvieux, Cedric ^x   Rouzioux, Christine ^f,o   Warszawski, Josiane ^b,c,d   Blanche, Stéphane ^g,p  

^a HÔPITAL LOUIS MOURIER   (France)

^b CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^c BICÊTRE HOSPITAL   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f University Lille   (France)

^g INSERM   (France)

^h Risks in Pregnancy University Department   (France)

ⁱ PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^j INSTITUT PIERRE LOUIS D EPIDÉMIOLOGIE ET DE SANTÉ PUBLIQUE   (France)

^k SERVICE DE DERMATOLOGIE   (France)

^l BICHAT HOSPITAL   (France)

^m Institut Cochin   (France)

ⁿ HÔPITAL ROBERT DEBRÉ   (France)

^o Virology Laboratory   (France)

^p HÔPITAL NECKER ENFANTS MALADES   (France)

^q DELAFONTAINE HOSPITAL   (France)

^r Internal Medicine Department   (France)

^s NANTES UNIVERSITY HOSPITAL   (France)

^t CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^u TOULOUSE UNIVERSITY HOSPITAL   (France)

^v Pediatrics Department   (France)

^w BORDEAUX UNIVERSITY HOSPITAL   (France)

^x RENNES UNIVERSITY HOSPITAL   (France)

more..

Author keywords

antiretroviral therapy; HIV; mother to child transmission.; pregnancy; treatment as prevention

Indexed keywords

ANTIRETROVIRUS AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ARTICLE; CONCEPTION; CONTROLLED STUDY; DELIVERY; DRUG EFFICACY; FEMALE; FIRST TRIMESTER PREGNANCY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INFANT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MONOTHERAPY; MULTICENTER STUDY; PERINATAL TRANSMISSION; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; SECOND TRIMESTER PREGNANCY; STILLBIRTH; THIRD TRIMESTER PREGNANCY; VERTICAL TRANSMISSION; VIRAL CLEARANCE; VIRUS LOAD; VIRUS TRANSMISSION; BLOOD; CLINICAL TRIAL; COHORT ANALYSIS; DRUG ADMINISTRATION; FERTILIZATION; FOLLOW UP; FRANCE; HIV INFECTIONS; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREVENTION AND CONTROL; STATISTICS AND NUMERICAL DATA; TRANSMISSION; VIROLOGY; YOUNG ADULT;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BLOOD; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; FERTILIZATION; FOLLOW-UP STUDIES; FRANCE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROSPECTIVE STUDIES; VIRAL LOAD; YOUNG ADULT;

EID: 84951985833     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ578     Document Type: Article

References (34)

1. Connor EM, Sperling RS, Gelber R, et al. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med 1994; 331:1173-80.
2. Mandelbrot L, Landreau-Mascaro A, Rekacewicz C, et al. Lamivudinezidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA 2001; 285:2083-93.
3. Cooper ER, Charurat M, Mofenson L, et al. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr 2002; 29:484-94.
4. Warszawski J, Tubiana R, Le Chenadec J, et al. Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort. AIDS 2008; 22:289-99.
5. Forbes JC, Alimenti AM, Singer J, et al. A national review of vertical HIV transmission. AIDS 2012; 26:757-63.
6. Townsend CL, Byrne L, Cortina-BorjaM, et al. Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011. AIDS 2014; 28:1049-57.
7. Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011; 365: 493-505.
8. Bailey H, Townsend C, Cortina-Borja M, Thorne C. Insufficient antiretroviral therapy in pregnancy: missed opportunities for prevention of mother-to-child transmission of HIV in Europe. Antivir Ther 2011; 16:895-903.
9. Tubiana R, Le Chenadec J, Rouzioux C, et al. Factors associated with mother-to-child transmission of HIV-1 despite a maternal viral load
10. British-HIV-Association. British HIV Association guidelines for the management of HIV infection in pregnant women 2012 (2014 interim review), 2014. Available at: http://www.bhiva.org/documents/Guide lines/Pregnancy/2012/BHIVA-Pregnancy-guidelines-update-2014.pdf. Accessed 14 June 2014.
11. Read PJ, Mandalia S, Khan P, et al. When should HAART be initiated in pregnancy to achieve an undetectable HIV viral load by delivery? AIDS 2012; 26:1095-103.
12. Panel-on-Treatment-of-HIV-Infected-Pregnant-Women-and-Prevention- of-Perinatal-Transmission Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States 2014 Available at http://aidsinfo. nih.gov/contentfiles/lvguidelines/PerinatalGL.pdf. Accessed 20 September 2014.
13. Morlat P, 2013. Available at: http://www.sante. gouv. fr/IMG/pdf/Rapport-Morlat-2013-Mise-en-ligne.pdf. Accessed 1 August 2015.
14. Tubiana R, Mandelbrot L, Le Chenadec J, et al. Lopinavir/ritonavir monotherapy as a nucleoside analogue-sparing strategy to prevent HIV-1 mother-to-child transmission: the ANRS 135 PRIMEVA phase 2/3 randomized trial. Clin Infect Dis 2013; 57:891-902.
15. Burgard M, Blanche S, Jasseron C, et al. Performance of HIV-1 DNA or HIV-1 RNA tests for early diagnosis of perinatal HIV-1 infection during anti-retroviral prophylaxis. J Pediatr 2012; 160: 60-6. e1.
16. Blanche S, Rouzioux C, Moscato ML, et al. HIV Infection in Newborns French Collaborative Study Group. A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. N Engl J Med 1989; 320:1643-8.
17. World Health Organization. Consolidated guidelines on the use of antiretrovirals drugs for treating and preventing HIV infection: recomendations for a public health approach. World Health Organization, 2013. Available at: http://www.who.int/hiv/pub/guidelines2013/download/en. Accessed 10 July 2014.
18. Tenthani L, Haas AD, Tweya H, et al. Retention in care under universal antiretroviral therapy for HIV-infected pregnant and breastfeeding women (Option B+) in Malawi. AIDS 2014; 28:589-98.
19. Shaffer N, Abrams EJ, Becquet R. Option B+ for prevention of motherto-child transmission of HIV in resource-constrained settings: great promise but some early caution. AIDS 2014; 28:599-601.
20. Loutfy MR, Wu W, Letchumanan M, et al. Systematic review of HIV transmission between heterosexual serodiscordant couples where the HIV-positive partner is fully suppressed on antiretroviral therapy. PloS One 2013; 8:e55747.
21. Taylor GP, Clayden P, Dhar J, et al. British HIV Association guidelines for the management of HIV infection in pregnant women 2012. HIV Med 2012; 13(suppl 2):87-157.
22. Briand N, Jasseron C, Sibiude J, et al. Cesarean section for HIV-infected women in the combination antiretroviral therapies era, 2000-2010. Am J Obstet Gynecol 2013; 209:335e1-12.
23. Briand N, Warszawski J, Mandelbrot L, et al; ANRS-EPF CO1-CO11 Study Group. Is intrapartum intravenous zidovudine for prevention of mother-to-child HIV-1 transmission still useful in the combination antiretroviral therapy era? Clin Infect Dis 2013; 57:903-14.
24. Neubert J, Pfeffer M, Borkhardt A, et al. Risk adapted transmission prophylaxis to prevent vertical HIV-1 transmission: effectiveness and safety of an abbreviated regimen of postnatal oral zidovudine. BMC Pregnancy Childbirth 2013; 13:22.
25. Heidari S, Mofenson L, Cotton MF, Marlink R, Cahn P, Katabira E. Antiretroviral drugs for preventing mother-to-child transmission of HIV: a review of potential effects on HIV-exposed but uninfected children. J Acquir Immune Defic Syndr 2011; 57:290-6.
26. Andre-Schmutz I, Dal-Cortivo L, Six E, et al. Genotoxic signature in cord blood cells of newborns exposed in utero to a zidovudine-based antiretroviral combination. J Infect Dis 2013; 208:235-43.
27. Siberry GK, Williams PL, Mendez H, et al. Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants. AIDS 2012; 26:1151-9.
28. Sibiude J, Le Chenadec J, Bonnet D, et al. In utero exposure to zidovudine and heart anomalies in the ANRS-EPF French Perinatal Cohort and the nested PRIMEVA randomized trial. Clin Infect Dis 2015; 61: 270-80.
29. Ford N, Mofenson L, Kranzer K, et al. Safety of efavirenz in first-trimester of pregnancy: a systematic review and meta-analysis of outcomes from observational cohorts. AIDS 2010; 24:1461-70.
30. Sibiude J, Mandelbrot L, Blanche S, et al. Association between prenatal exposure to antiretroviral therapy and birth defects: an analysis of the French perinatal cohort study (ANRS CO1/CO11). PLoS Med 2014; 11:e1001635.
31. Chen JY, Ribaudo HJ, Souda S, et al. Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana. J Infect Dis 2012; 206:1695-705.
32. Powis KM, Kitch D, Ogwu A, et al. Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancy. J Infect Dis 2011; 204:506-14.
33. Townsend C, Schulte J, Thorne C, et al. Antiretroviral therapy and preterm delivery-a pooled analysis of data from the United States and Europe. BJOG 2010; 117:1399-410.
34. Sibiude J, Warszawski J, Tubiana R, et al. Premature delivery in HIVinfected women starting protease inhibitor therapy during pregnancy: role of the ritonavir boost? Clin Infect Dis 2012; 54:1348-60.