Immune suppressive activity of the influenza fusion peptide

Virus Research

Volumn 211, Issue , 2016, Pages 126-132

  Bahrami, Shervin ^a,b   Laska, Magdalena Janina ^b   Pedersen, Finn Skou ^b   Duch, Mogens ^a,b  

^a SKAUvaccines   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Fusion peptide; Immune suppression; Influenza

Indexed keywords

CYTOKINE; FLU ISU PEPTIDE; HEMAGGLUTININ; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; INFLUENZA VIRUS HEMAGGLUTININ; PEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; INFLUENZA A VIRUS; INFLUENZA B VIRUS; INFLUENZA VIRUS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; CELL LINE; CHEMISTRY; GENETICS; IMMUNOLOGY; INFLUENZA; MOLECULAR GENETICS; ORTHOMYXOVIRIDAE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; VIROLOGY;

AMINO ACID SEQUENCE; CELL LINE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA, HUMAN; MOLECULAR SEQUENCE DATA; ORTHOMYXOVIRIDAE; PEPTIDES; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 84951853734     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2015.10.012     Document Type: Article

References (27)

1. Ali S.A., Rees R.C., Oxford J. Modulation of human natural killer cytotoxicity by influenza virus and its sub-unit protein. Immunology 1984, 52(4):687-695.
2. Cassidy L.F., Lyles D.S., Abramson J.S. Depression of polymorphonuclear leukocyte functions by purified influenza virus hemagglutinin and sialic acid-binding lectins. J. Immunol. 1989, 142(12):4401-4406.
3. Cianciolo G.J., Bogerd H., Snyderman R. Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation. Immunol. Lett. 1988, 19(1):7-13.
4. Cianciolo G.J., Copeland T.D., Oroszlan S., Snyderman R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 1985, 230(4724):453-455.
5. Denner J., Norley S., Kurth R. The immunosuppressive peptide of HIV-1: functional domains and immune response in AIDS patients. AIDS 1994, 8(8):1063-1072.
6. Gottlieb R.A., Kleinerman E.S., O'Brian C.A., Tsujimoto S., Cianciolo G.J., Lennarz W.J. Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E. J. Immunol. 1990, 145(8):2566-2570.
7. Haraguchi S., Good R.A., Day-Good N.K. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol. Res. 2008, 41(1):46-55.
8. Haraguchi S., Good R.A., Day N.K. Immunosuppressive retroviral peptides: cAMP and cytokine patterns. Immunol. Today 1995, 16(12):595-603.
9. Haraguchi S., Good R.A., James-Yarish M., Cianciolo G.J., Day N.K. Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. Proc. Natl. Acad. Sci. U. S. A. 1995, 92(8):3611-3615.
10. Harrell R.A., Cianciolo G.J., Copeland T.D., Oroszlan S., Snyderman R. Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. J. Immunol. 1986, 136(10):3517-3520.
11. Holm C.K., Jensen S.B., Jakobsen M.R., Cheshenko N., Horan K.A., Moeller H.B., Gonzalez-Dosal R., Rasmussen S.B., Christensen M.H., Yarovinsky T.O., Rixon F.J., Herold B.C., Fitzgerald K.A., Paludan S.R. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nat. Immunol. 2012, 13(8):737-743.
12. Kleinerman E.S., Lachman L.B., Knowles R.D., Snyderman R., Cianciolo G.J. A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. J. Immunol. 1987, 139(7):2329-2337.
13. Langley W.A., Thoennes S., Bradley K.C., Galloway S.E., Talekar G.R., Cummings S.F., Vareckova E., Russell R.J., Steinhauer D.A. Single residue deletions along the length of the influenza HA fusion peptide lead to inhibition of membrane fusion function. Virology 2009, 394(2):321-330.
14. Mangeney M., Heidmann T. Tumor cells expressing a retroviral envelope escape immune rejection in vivo. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(25):14920-14925.
15. Mao H., Tu W., Liu Y., Qin G., Zheng J., Chan P.L., Lam K.T., Peiris J.S., Lau Y.L. Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. J. Virol. 2010, 84(9):4148-4157.
16. Mehrotra S., Mishra K.P., Yadav V.S., Bhattacharya M., Pandey D., Haq W., Singh V.K. Immunomodulation by peptide analogs of retroviral envelope protein. Peptides 2003, 24(7):979-985.
17. Monell C.R., Strand M. Structural and functional similarities between synthetic HIV gp41 peptides and defensins. Clin. Immunol. Immunopathol. 1994, 71(3):315-324.
18. Morozov V.A., Morozov A.V., Semaan M., Denner J. Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1. Retrovirology 2012, 9:67.
19. Noone C.M., Lewis E.A., Frawely A.B., Newman R.W., Mahon B.P., Mills K.H., Johnson P.A. Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of interleukin 12 p35 transcription in murine bone marrow-derived dendritic cells. J. Gen. Virol. 2005, 86(Pt 7):1885-1890.
20. Oostendorp R.A., Meijer C.J., Scheper R.J. Immunosuppression by retroviral-envelope-related proteins, and their role in non-retroviral human disease. Crit. Rev. Oncol. Hematol. 1993, 14(3):189-206.
21. Quintana F.J., Gerber D., Kent S.C., Cohen I.R., Shai Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J. Clin. Invest. 2005, 115(8):2149-2158.
22. Ruegg C.L., Monell C.R., Strand M. Identification, using synthetic peptides, of the minimum amino acid sequence from the retroviral transmembrane protein p15E required for inhibition of lymphoproliferation and its similarity to gp21 of human T-lymphotropic virus types I and II. J. Virol. 1989, 63(8):3250-3256.
23. Schildberger A., Rossmanith E., Eichhorn T., Strassl K., Weber V. Monocytes, peripheral blood mononuclear cells, and THPcells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide. Mediators Inflamm. 2013, 2013:697972.
24. Schlecht-Louf G., Renard M., Mangeney M., Letzelter C., Richaud A., Ducos B., Bouallaga I., Heidmann T. Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(8):3782-3787.
25. Sigalov A.B. Novel mechanistic insights into viral modulation of immune receptor signaling. PLoS Pathog. 2009, 5(7):e1000404.
26. Takahashi A., Day N.K., Luangwedchakarn V., Good R.A., Haraguchi S. A retroviral-derived immunosuppressive peptide activates mitogen-activated protein kinases. J. Immunol. 2001, 166(11):6771-6775.
27. Yaddanapudi K., Palacios G., Towner J.S., Chen I., Sariol C.A., Nichol S.T., Lipkin W.I. Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses. FASEB J. 2006, 20(14):2519-2530.