Novel mechanism of immunosuppression by influenza virus haemagglutinin: Selective suppression of interleukin 12 p35 transcription in murine bone marrow-derived dendritic cells

Journal of General Virology

Volumn 86, Issue 7, 2005, Pages 1885-1890

  Noone, Cariosa M ^a   Lewis, Ellen A ^a   Frawely, Anne B ^a   Newman, Robert W ^b   Mahon, Bernard P ^a   Mills, Kingston H ^c   Johnson, Patricia A ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN P35; PROTEIN P40; PROTEIN SUBUNIT; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE PREDISPOSITION; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; IMMUNE DEFICIENCY; INFLUENZA; INFLUENZA VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DOWN-REGULATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNE TOLERANCE; INFLUENZA A VIRUS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P35; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; PROTEIN SUBUNITS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

INFLUENZA VIRUS; MURINAE;

EID: 21444432873     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.80891-0     Document Type: Article

References (33)

1. Aste-Amezaga, M., Ma, X., Sartori, A. & Trinchieri, G. (1998). Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol 160, 5936-5944.
2. Beadling, C. & Slifka, M. K. (2004). How do viral infections predispose patients to bacterial infections? Curr Opin Infect Dis 17, 185-191.
3. Brand, C. M. & Skehel, J. J. (1972). Crystalline antigen from the influenza virus envelope. Nat New Biol 238, 145-147.
4. Colamussi, M. L., White, M. R., Crouch, E. & Hartshorn, K. L. (1999). Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria. Blood 93, 2395-2403.
5. Cousens, L. P., Orange, J. S., Su, H. C. & Biron, C. A. (1997). Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc Natl Acad Sci U S A 94, 634-639.
6. Gillessen, S., Carvajal, D., Ling, P. & 7 other authors (1995). Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol 25, 200-206.
7. Glezen, W. P. (2004). The changing epidemiology of respiratory syncytial virus and influenza: impetus for new control measures. Pediatr Infect Dis J 23, S202-S206.
8. + dendritic cells by specifically inducing p35 gene transcription. J Exp Med 194, 1021-1032.
9. Hament, J.-M., Kimpen, J. L. L., Fleer, A. & Wolfs, T. F. W. (1999). Respiratory viral infection predisposing for bacterial disease: a concise review. FEMS Immunol Med Microbiol 26, 189-195.
10. Hartshorn, K. L., Liou, L. S., White, M. R., Kazhdan, M. M., Tauber, J. L. & Tauber, A. I. (1995). Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins. J Immunol 154, 3952-3960.
11. Heinzel, F. P., Hujer, A. M., Ahmed, F. N. & Rerko, R. M. (1997). In vivo production and function of IL-12 p40 homodimers. J Immunol 158, 4381-4388.
12. Howlett, R. (2004). Infectious disease: past and future of an old foe. Nature 432, 817.
13. Hussell, T. & Williams, A. (2004). Ménage à trois of bacterial and viral pulmonary pathogens delivers coup de grace to the lung. Clin Exp Immunol 137, 8-11.
14. Lehmann, J., Bellmann, S., Werner, C., Schröder, R., Schütze, N. & Alber, G. (2001). IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella Enteritidis. J Immunol 167, 5304-5315.
15. LeVine, A. M., Koeningsknecht, V. & Stark, J. M. (2001). Decreased pulmonary clearance of S. pneumoniae following influenza A infection in mice. J Virol Methods 94, 173-186.
16. Magram, J., Connaughton, S. E., Warrier, R. R. & 7 other authors (1996). IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4, 471-481.
17. Marcus, P. I., Rojek, J. M. & Sekellick, M. J. (2005). Interferon induction and/or production and its suppression by influenza A viruses. J Virol 79, 2880-2890.
18. McGuirk, P., McCann, C. & Mills, K. H. G. (2002). Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 195, 221-231.
19. Murphy, T. L., Cleveland, M. G., Kulesza, P., Magram, J. & Murphy, K. M. (1995). Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol Cell Biol 15, 5258-5267.
20. O'Garra, A. (1998). Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275-283.
21. Okamoto, S., Kawabata, S., Nakagawa, I., Okuno, Y., Goto, T., Sano, K. & Hamada, S. (2003). Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. J Virol 77, 4104-4112.
22. Oppmann, B., Lesley, R., Blom, B. & 22 other authors (2000). Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725.
23. Oxenius, A., Karrer, U., Zinkernagel, R. M. & Hengartner, H. (1999). IL-12 is not required for induction of type 1 cytokine responses in viral infections. J Immunol 162, 965-973.
24. Pirhonen, J., Matikainen, S. & Julkunen, I. (2002). Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 169, 5673-5678.
25. Reichert, T. A., Simonsen, L., Sharma, A., Pardo, S. A., Fedson, D. S. & Miller, M. A. (2004). Influenza and the winter increase in mortality in the United States, 1959-1999. Am J Epidemiol 160, 492-502.
26. Sanford, B. A. & Ramsay, M. A. (1987). Bacterial adherence to the upper respiratory tract of ferrets infected with influenza A virus. Proc Soc Exp Biol Med 185, 120-128.
27. Schijns, V. E. C. J., Haagmans, B. L., Wierda, C. M. H., Kruithof, B., Heijnen, I. A. F. M., Alber, G. & Horzinek, M. C. (1998). Mice lacking IL-12 develop polarized Th1 cells during viral infection. J Immunol 160, 3958-3964.
28. Seki, M., Higashiyama, Y., Tomono, K. & 9 other authors (2004). Acute infection with influenza virus enhances susceptibility to fatal pneumonia following Streptococcus pneumoniae infection in mice with chronic pulmonary colonization with Pseudomonas aeruginosa. Clin Exp Immunol 137, 35-40.
29. Snijders, A., Hilkens, C. M., van der Pouw Kraan, T. C., Engel, M., Aarden, L. A. & Kapsenberg, M. L. (1996). Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 156, 1207-1212.
30. Takase, H., Nitanai, H., Yamamura, E. & Otani, T. (1999). Facilitated expansion of pneumococcal colonization from the nose to the lower respiratory tract in mice preinfected with influenza virus. Microbiol Immunol 43, 905-907.
31. Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Bridges, C. B., Cox, N. J. & Fukuda, K. (2004). Influenza-associated hospitalizations in the United States. JAMA 292, 1333-1340.
32. Trinchieri, G. (1998). Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 70, 83-243.
33. Xing, Z. (2001). Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required. Cell Mol Biol 47, 689-694.