Biodegradable Eri silk nanoparticles as a delivery vehicle for bovine lactoferrin against MDA-MB-231 and MCF-7 breast cancer cells

International Journal of Nanomedicine

Volumn 11, Issue , 2015, Pages 25-44

  Roy, Kislay ^a   Patel, Yogesh S ^a   Kanwar, Rupinder K ^a   Rajkhowa, Rangam ^a   Wang, Xungai ^a   Kanwar, Jagat R ^a  

^a DEAKIN UNIVERSITY   (Australia)

Author keywords

Apoptosis; Bovine lactoferrin; Breast cancer; Epidermal growth factor receptor; Silk nanoparticles

Indexed keywords

CHITOSAN; EPIDERMAL GROWTH FACTOR; ERI SILK NANOPARTICLE; LACTOFERRIN; LACTOFERRIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NANOPARTICLE; RECEPTOR; SURVIVIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG; APOLACTOFERRIN; APOPROTEIN; CELL SURFACE RECEPTOR; IRON; LACTOFERRIN RECEPTORS; SILK;

ARTICLE; BREAST CANCER CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; ENDOCYTOSIS; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; INTERNALIZATION; MATERIAL COATING; MCF 7 CELL LINE; MDA MB 231 CELL LINE; PARTICLE SIZE; PROTEIN EXPRESSION; ANIMAL; APOPTOSIS; BOVINE; BREAST NEOPLASMS; CHEMISTRY; DEVICES; DRUG EFFECTS; FEMALE; MCF-7 CELL LINE; METABOLISM; MOTH; MOUSE; PATHOLOGY; PROCEDURES;

ANIMALS; APOPROTEINS; APOPTOSIS; BREAST NEOPLASMS; CATTLE; CHITOSAN; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; IRON; LACTOFERRIN; MCF-7 CELLS; MICE; MOTHS; NANOPARTICLES; RECEPTORS, CELL SURFACE; SILK;

EID: 84951820053     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S91810     Document Type: Article

References (49)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.
2. Mita K, Kasahara M, Sasaki S, et al. The genome sequence of silkworm, Bombyx mori. DNA Res. 2004;11(1):27-35.
3. Sørensen M, Sørensen SPL. The proteins in whey. CR TraV Lab, Carlsberg, Copenhagen. 1939;23:55-99.
4. Johansson B. Isolation of crystalline lactoferrin from human milk. Acta Chem Scand. 1968;23(2):683-684.
5. Prasad MD, Muthulakshmi M, Arunkumar KP, et al. SilkSatDb: a microsatellite database of the silkworm, Bombyx mori. Nucleic Acids Res. 2005;33(Database issue):D403-D406.
6. Papanicolaou A, Gebauer-Jung S, Blaxter ML, Owen McMillan W, Jiggins CD. ButterflyBase: a platform for lepidopteran genomics. Nucleic Acids Res. 2008;36(Database issue):D582-D587.
7. Negre V, Hôtelier T, Volkoff A, et al. SPODOBASE: an EST database for the lepidopteran crop pest Spodoptera. BMC Bioinformatics. 2006;7:322.
8. Grimaldi D, Engel M. Evolution of the Insects. Cambridge: Cambridge University Press; 2005.
9. Dunning AM, Healey CS, Pharoah PDP, Teare MD, Ponder BAJ, Easton DF. A systematic review of genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1999;8(10): 843-854.
10. Croce CM. Oncogenes and cancer. N Engl J Med. 2008;358(5):502-511.
11. Knudson AG. Two genetic hits (more or less) to cancer. Nat Rev Cancer. 2001;1(2):157-162.
12. Zhang YQ. Applications of natural silk protein sericin in biomaterials. Biotechnol Adv. 2002;20(2):91-100.
13. Sasaki M, Kato N, Watanabe H, Yamada H. Silk protein, sericin, suppresses colon carcinogenesis induced by 1,2-dimethylhydrazine in mice. Oncol Rep. 2000;7(5):1049-1052.
14. Kanwar JR, Kanwar RK, Sun X, et al. Molecular and biotechnological advances in milk proteins in relation to human health. Curr Protein Pept Sci. 2009;10(4):308-338.
15. Gibbons JA, Kanwar RK, Kanwar JR. Lactoferrin and cancer in different cancer models. Front Biosci (Schol Ed). 2010;3:1080-1088.
16. Kanwar RK, Kanwar JR. Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer. Protein Pept Lett. 2013;20(4):450-458.
17. Kanwar JR, Palmano KP, Sun X, et al. 'Iron-saturated' lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy. Immunol Cell Biol. 2008;86(3):277-288.
18. Gibbons JA, Kanwar JR, Kanwar RK. Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer. BMC Cancer. 2015;15:425.
19. Mahidhara G, Kanwar RK, Roy K, Kanwar JR. Oral administration of iron-saturated bovine lactoferrin-loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism. Int J Nanomedicine. 2015;10:4081-4098.
20. Xia Y, Lu Y. Fabrication and properties of conductive conjugated polymers/silk fibroin composite fibers. Compos Sci Technol. 2008;68(6):1471-1479.
21. Vepari C, Kaplan DL. Silk as a biomaterial. Prog Polym Sci. 2007;32(8-9):991-1007.
22. Bini E, Knight DP, Kaplan DL. Mapping domain structures in silks from insects and spiders related to protein assembly. J Mol Biol. 2004;335(1):27-40.
23. Altman GH, Diaz F, Jakuba C, et al. Silk-based biomaterials. Biomaterials. 2003;24(3):401-416.
24. Wang X, Hu X, Daley A, Rabotyagova O, Cebe P, Kaplan DL. Nanolayer biomaterial coatings of silk fibroin for controlled release. J Control Release. 2007;121(3):190-199.
25. Lammel AS, Hu X, Park SH, Kaplan DL, Scheibel TR. Controlling silk fibroin particle features for drug delivery. Biomaterials. 2010;31(16):4583-4591.
26. Wang X, Yucel T, Lu Q, Hu X, Kaplan DL. Silk nanospheres and microspheres from silk/pva blend films for drug delivery. Biomaterials. 2010;31(6):1025-1035.
27. Wang X, Wenk E, Hu X, et al. Silk coatings on PLGA and alginate microspheres for protein delivery. Biomaterials. 2007;28(28):4161-4169.
28. Talukdar S, Mandal M, Hutmacher DW, Russell PJ, Soekmadji C, Kundu SC. Engineered silk fibroin protein 3D matrices for in vitro tumor model. Biomaterials. 2011;32(8):2149-2159.
29. Rajkhowa R, Wang L, Kanwar J, Wang X. Fabrication of ultrafine powder from eri silk through attritor and jet milling. Powder Technol. 2009;191(1-2):155-163.
30. Kanwar JR, Kanwar RK. Gut health immunomodulatory and anti-inflammatory functions of gut enzyme digested high protein micro-nutrient dietary supplement-Enprocal. BMC Immunol. 2009;10:7.
31. Roy K, Kanwar RK, Krishnakumar S, Cheung CH, Kanwar JR. Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model. Int J Nanomedicine. 2015;10:1019-1043.
32. Kanwar RK, Ganguly NK, Kanwar JR, Kumar L, Walia BN. Impairment of Na+, K+-ATPase activity following enterotoxigenic Campylobacter jejuni infection: changes in Na+, Cl- and 3-O-methyl-D-glucose transport in vitro, in rat ileum. FEMS Microbiol Lett. 1994;124(3):381-385.
33. Kanwar RK, Ganguly NK, Kumar L, Rakesh J, Panigrahi D, Walia BN. Calcium and protein kinase C play an important role in Campylobacter jejuni-induced changes in Na+ and Cl- transport in rat ileum in vitro. Biochim Biophys Acta. 1995;1270(2-3):179-192.
34. Australian Institute of Health and Welfare (AIHW). Breast cancer in Australia: an overview, 2009. In: Cancer Series Canberra: Australian Institute of Health and Welfare and National Breast and Ovarian Cancer Centre. Bruce, ACT: AIHW. 2009:170.
35. Kanwar JR, Mahidhara G, Kanwar RK. Antiangiogenic therapy using nanotechnological-based delivery system. Drug Discov Today. 2011;16(5-6):188-202.
36. Ryan BM, O'Donovan N, Duffy MJ. Survivin: a new target for anti-cancer therapy. Cancer Treat Rev. 2009;35(7):553-562.
37. Kanwar JR, Mahidhara G, Kanwar RK. Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy. Nanomedicine (Lond). 2012;7(10):1521-1550.
38. Damiens E, Mazurier J, el Yazidi I, et al. Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells. Biochim Biophys Acta. 1998;1402(3):277-287.
39. Duarte DC, Nicolau A, Teixeira JA, Rodrigues LR. The effect of bovine milk lactoferrin on human breast cancer cell lines. J Dairy Sci. 2011;94(1):66-76.
40. Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des. 2009;15(17):1956-1973.
41. Iigo M, Kuhara T, Ushida Y, Sekine K, Moore MA, Tsuda H. Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clin Exp Metastasis. 1999;17(1):35-40.
42. Kanwar JR, Mahidhara G, Roy K, et al. Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc. Nanomedicine (Lond). 2015;10(1):35-55.
43. Ashida K, Sasaki H, Suzuki YA, Lönnerdal B. Cellular internalization of lactoferrin in intestinal epithelial cells. BioMetals. 2004;17(3):311-315.
44. Jiang R, Lopez V, Kelleher SL, Lönnerdal B. Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in caco-2 cells. J Cell Physiol. 2011;226(11):3022-3031.
45. Subia B, Chandra S, Talukdar S, Kundu SC. Folate conjugated silk fibroin nanocarriers for targeted drug delivery. Integr Biol (Camb). 2014;6(2):203-214.
46. Ebrahim F, Shankaranarayanan JS, Kanwar JR, Gurudevan S, Krishnan UM, Kanwar RK. Identification of unprecedented anticancer properties of high molecular weight biomacromolecular complex containing bovine lactoferrin (HMW-bLf). PLoS One. 2014;9(9):e106568.
47. Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med. 2008;358(11):1160-1174.
48. Omidi Y, Barar J. Induction of human alveolar epithelial cell growth factor receptors by dendrimeric nanostructures. Int J Toxicol. 2009;28(2):113-122.
49. Mohan KV, Gunasekaran P, Varalakshmi E, Hara Y, Nagini S. In vitro evaluation of the anticancer effect of lactoferrin and tea polyphenol combination on oral carcinoma cells. Cell Biol Int. 2007;31(6):599-608.