Antibody responses after primary immunization in infants born to women receiving a Pertussis-containing vaccine during pregnancy: Single arm observational study with a historical comparator

Clinical Infectious Diseases

Volumn 61, Issue 11, 2015, Pages 1637-1644

  Ladhani, Shamez N ^a,b   Andrews, Nick J ^a   Southern, Jo ^a   Jones, Christine E ^b   Amirthalingam, Gayatri ^a   Waight, Pauline A ^a   England, Anna ^a   Matheson, Mary ^a   Bai, Xilian ^c   Findlow, Helen ^c   Burbidge, Polly ^d   Thalasselis, Vasili ^d   Hallis, Bassam ^a   Goldblatt, David ^d   Borrow, Ray ^c   Heath, Paul T ^b   Miller, Elizabeth ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

conjugate vaccines

Indexed keywords

DIPHTHERIA PERTUSSIS POLIOMYELITIS TETANUS VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; MENINGOCOCCUS VACCINE; PERTUSSIS TOXIN; PNEUMOCOCCUS VACCINE; TETANUS ANTIBODY; 13-VALENT PNEUMOCOCCAL VACCINE; BACTERIAL ANTIGEN; BACTERIUM ANTIBODY; DIPHTHERIA PERTUSSIS TETANUS VACCINE; HAEMOPHILUS INFLUENZA TYPE B POLYSACCHARIDE VACCINE-TETANUS TOXIN CONJUGATE; HAEMOPHILUS VACCINE; IMMUNOGLOBULIN G; POLIOMYELITIS VACCINE; TETANUS TOXOID; VACCINE;

ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; CONTROLLED STUDY; DIPHTHERIA; FEMALE; HUMAN; IMMUNIZATION; MAJOR CLINICAL STUDY; NEWBORN; OBSERVATIONAL STUDY; PERTUSSIS; PREGNANCY; PRIORITY JOURNAL; TETANUS; UNITED KINGDOM; BLOOD; BORDETELLA PERTUSSIS; ENGLAND; IMMUNOLOGY; INFANT; MALE; PASSIVE IMMUNIZATION; SECONDARY IMMUNIZATION; WHOOPING COUGH;

ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BORDETELLA PERTUSSIS; COHORT STUDIES; DIPHTHERIA-TETANUS-ACELLULAR PERTUSSIS VACCINES; ENGLAND; FEMALE; HAEMOPHILUS VACCINES; HUMANS; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN G; INFANT; MALE; MENINGOCOCCAL VACCINES; PNEUMOCOCCAL VACCINES; POLIOVIRUS VACCINE, INACTIVATED; PREGNANCY; TETANUS TOXOID; VACCINES, CONJUGATE; WHOOPING COUGH;

EID: 84951571153     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ695     Document Type: Article

References (24)

1. Department of Health. Pregnant women to be offered whooping cough vaccination. Department of Health 2012 Available at http://www.dh.gov.uk/health/2012/09/whooping-cough/. Accessed 17 June 2015.
2. Amirthalingam G, Gupta S, Campbell H. Pertussis immunization and control in England and Wales, 1957 to 2012: a historical review. Euro Surveill 2013; 18:pii:20587.
3. Gall SA, Myers J, Pichichero M. Maternal immunization with tetanusdiphtheria-pertussis vaccine: effect on maternal and neonatal serum antibody levels. Am J Obstet Gynecol 2011; 204:334-5.
4. Leuridan E, Hens N, Peeters N, de WL, Van Der Meeren O, Van DP. Effect of a prepregnancy pertussis booster dose on maternal antibody titers in young infants. Pediatr Infect Dis J 2011; 30:608-10.
5. Amirthalingam G, Andrews N, Campbell H, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet 2014; 384:1521-8.
6. Dabrera G, Amirthalingam G, Andrews N, et al. A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England andWales, 2012-2013. Clin Infect Dis 2015; 60:333-7.
7. Niewiesk S. Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies. Front Immunol 2014; 5:446.
8. Wood N, Siegrist CA. Neonatal immunization: where do we stand? Curr Opin Infect Dis 2011; 24:190-5.
9. Department of Health and Public Health England. MenC vaccination schedule: planned changes from June 2013, 2013. Available at: https://www.gov.uk/government/uploads/system/uploads/attachment-data/file/336171/MenC-information-for-healthcare-professionals-V7-.pdf. Accessed 17 June 2015.
10. Phipps DC, West J, Eby R, Koster M, Madore DV, Quataert SA. An ELISA employing a Haemophilus influenzae type b oligosaccharidehuman serum albumin conjugate correlates with the radioantigen binding assay. J Immunol Methods 1990; 135:121-8.
11. Melville-Smith ME. Diphtheria and tetanus antitoxins. In:Wreghitt TG, Morgan-Capner P, eds. ELISA in the Clinical Microbiology. London: Public Health Laboratory Service, 1990:136-47.
12. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH). Validation of analytical procedures: text and methodology q2(r1). ICH Harmonised Tripartite Guideline, 2005. Available at: http://www.ich.org/fileadmin/Public-Web-Site/ICH-Products/Guidelines/Quality/Q2-R1/Step4/Q2-R1-Guideline.pdf. Accessed 17 June 2015.
13. Maslanka SE, Gheesling LL, Libutti DE, et al. Standardization and a multilaboratory comparison of Neisseria meningitidis serogroup A and C serum bactericidal assays. The Multilaboratory Study Group. Clin Diagn Lab Immunol 1997; 4:156-67.
14. Wernette CM, Frasch CE, Madore D, et al. Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides. Clin Diagn Lab Immunol 2003; 10:514-9.
15. Plotkin SA. Correlates of protection induced by vaccination. Clin Vaccine Immunol 2010; 17:1055-65.
16. Cherry JD, Gornbein J, Heininger U, Stehr K. A search for serologic correlates of immunity to Bordetella pertussis cough illnesses. Vaccine 1998; 16:1901-6.
17. Ladhani SN, Andrews NJ, Waight P, et al. Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunization schedule. Vaccine 2015; 33:648-55.
18. Hardy-Fairbanks AJ, Pan SJ, Decker MD, et al. Immune responses in infants whose mothers received Tdap vaccine during pregnancy. Pediatr Infect Dis J 2013; 32:1257-60.
19. Munoz FM, Bond NH, Maccato M, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA 2014; 311:1760-9.
20. Siegrist CA. Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants. Vaccine 2003; 21:3406-12.
21. Findlow H, Borrow R, Andrews N, et al. Immunogenicity of a single dose of meningococcal group C conjugate vaccine given at 3 months of age to healthy infants in the United kingdom. Pediatr Infect Dis J 2012; 31:616-22.
22. Nohynek H, Gustafsson L, Capeding MR, et al. Effect of transplacentally acquired tetanus antibodies on the antibody responses to Hemophilus influenzae type b-tetanus toxoid conjugate and tetanus toxoid vaccines in Filipino infants. Pediatr Infect Dis J 1999; 18:25-30.
23. Healy CM, Rench MA, Baker CJ. Implementation of cocooning against pertussis in a high-risk population. Clin Infect Dis 2011; 52:157-62.
24. Public Health England. Vaccination against pertussis (Whooping cough) for pregnant women-2014. Information for healthcare professionals. Public Health England, 2014. www.gov.uk/government/uploads/system/uploads/attachment-data/file/338567/PHE-pertussis-in-pregnancy- information-for-HP-2014-doc-V3.pdf. Accessed 17 June 2015.