Evidence for a gastrointestinal-renal kaliuretic signaling axis in humans

Kidney International

Volumn 88, Issue 6, 2015, Pages 1383-1391

  Preston, Richard A ^a,b   Afshartous, David ^a   Rodco, Rolando ^a   Alonso, Alberto B ^a   Garg, Dyal ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

Distal tubule; Potassium channels; Signaling

Indexed keywords

ALDOSTERONE; EPLERENONE; INSULIN; POTASSIUM; POTASSIUM CHLORIDE; SODIUM;

ADULT; ARTICLE; FEMALE; GASTROINTESTINAL RENAL KALIURETIC SIGNALING AXIS; HUMAN; HUMAN EXPERIMENT; INSULIN RESPONSE; KALIURESIS; MALE; NORMAL HUMAN; POTASSIUM BLOOD LEVEL; POTASSIUM EXCRETION; POTASSIUM INTAKE; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SODIUM INTAKE; SODIUM URINE LEVEL;

EID: 84951569299     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.243     Document Type: Article

References (41)

1. Malnic G, Giebisch G, Muto S et al. Regulation of K+ excretion. In: Alpern RJ, Caplan MJ, Moe OW (eds). Seldin and Giebisch's The Kidney. Physiology and Pathophysiology. Chap 49, Elsevier, Amsterdam, 2012, pp 1659-1715
2. Gumz ML, Rabinowitz LR, Wingo CS. An integrated view of potassium homeostasis. N Engl J Med 2015; 373: 60-72
3. Palmer BF. Renal physiology: Regulation of potassium homeostasis. Clin J Am Soc Nephrol 2015; 10: 1050-1060
4. Young DB. Analysis of long-term potassium regulation. Endocr Rev 1985; 6: 24-44
5. Young DB. Relationship between plasma potassium concentration and renal potassium excretion. Am J Physiol 1982; 42: F599-F603
6. Young DB. Quantitative analysis of aldosterone's role in potassium regulation. Am J Physiol Renal Fluid Electrolyte Physiol 1988; 255: F811-F822
7. Young DB, Paulsen AW. Interrelated effects of aldosterone and plasma potassium on potassium excretion. Am J Physiol Renal Fluid Electrolyte Physiol 1983; 244: F28-F34
8. Rabinowitz L. Aldosterone and potassium homeostasis. Kidney Int 1996; 49: 1738-1742
9. Rabinowitz L, Sarason RL, Yamauchi H. Sheep renal potassium excretion: efferent kaliuretic regulatory factors. Am J Physiol 1984; 247: F520-F526
10. Rabinowitz L, Green DM, Sarason RL et al. Homeostatic potassium excretion in fed and fasted sheep. Am J Physiol Regul Integr Comp Physiol 1988; 254: R357-R380
11. Rabinowitz L. Model of homeostatic regulation of potassium excretion in sheep. Am J Physiol Regul Integr Comp Physiol 1988; 254: R381-R388
12. Rabinowitz L, Sarason RL, Yamauchi H. Effect of aldosterone on potassium excretion during potassium chloride infusion in sheep. Am J Physiol Regul Integr Comp Physiol 1985; 249: R455-R461
13. Rabinowitz L, Sarason RL, Yamauchi H. Effects of KCl infusion on potassium excretion in sheep. Am J Physiol Renal Fluid Electrolyte Physiol 1985; 249: F263-F271
14. Youn JH. Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol 2013; 33: 248-256
15. Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol 2009; 71: 381-401
16. Lee FN, Oh G, McDonough AA et al. Evidence for a gut factor in K homeostasis. Am J Physiol Renal Physiol 2007; 293: F541-F547
17. Oh KS, Oh YT, Kim SW et al. Gut sensing of dietary K+ intake increases renal K+ excretion. Am J Physiol Regul Integr Comp Physiol 2011; 301: R421-R429
18. Greenlee M, Wingo CS, McDonough AA et al. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med 2009; 150: 619-625
19. Michell AR, Debnam ES, Unwin RJ. Regulation of renal function by the gastrointestinal tract: potential role of gut-derived peptides and hormones. Annu Rev Physiol 2008; 70: 379-403
20. Calò L, Borsatti A, Favaro S et al. Kaliuresis in normal subjects following oral potassium citrate intake without increased plasma potassium concentration. Nephron 1995; 69: 253-258
21. Preston RA, Afshartous D, Garg D et al. Mechanisms of impaired potassium handling with dual renin-angiotensin-aldosterone blockade in chronic kidney disease. Hypertension 2009; 53: 754-760
22. Preston RA, Afshartous D, Alonso AB. Effects of selective versus nonselective cyclooxygenase inhibition on dynamic renal potassium excretion: a randomized trial. Clin Pharmacol Ther 2008; 84: 208-211
23. Preston RA, Baltodano NM, Alonso A et al. Comparative effects on renal potassium excretion of candesartan versus lisinopril in hypertensive patients with type II diabetes mellitus. J Clin Pharmacol 2002; 42: 754-761
24. Sica DA. Hyperkalemia risk in chronic kidney disease. Deterrent to the use of aldosterone receptor antagonism or not. Hypertension 2009; 53: 749-750
25. Sica DA. Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Failure Rev 2005; 10: 23-29
26. Ravis WR, Reid S, Sica DA et al. Pharmacokinetics of eplerenone after single and multiple dosing in volunteers with and without renal impairment. J Clin Pharmacol 2005; 45: 810-821
27. Colussi G, Cantena C, Sechi LA. Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension. J Hypertens 2013; 31: 3-15
28. Mattsson C, Reynolds RM, Simonyte K et al. Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men. J Clin Endocrinol Metab 2009; 94: 1347-1352
29. Eudy RJ, Sahasrabudhe V, Sweeney K et al. The use of plasma aldosterone and urinary sodium to potassium ration as translatable quantitative biomarkers of mineralocorticoid receptor antagonism. J Translational Med 2011; 9: 180-191
30. Wingo CS, Kokko JP, Jacobson HR. Effects of in vitro aldosterone on the rabbit cortical collecting tubule. Kidney Int 1985; 28: 51-57
31. O'Neil RG. Aldosterone regulation of sodium and potassium transport in the cortical collecting duct. Semin Nephrol 1990; 10: 365-374
32. Zwanzig M, Minuth WW, Gross P. Action of aldosterone on cultured renal collecting duct cells during the latent period. Renal Physiol Biochem 1990; 13: 285-294
33. Sorensen MV, Grossmann S, Roesinger M et al. Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney Int 83: 811-8242013
34. McDonough AA, Youn JH. Need to quickly excrete K+? Turn off NCC. Kidney Int 2013; 83: 779-782
35. van der Lubbe N, Moes AD, Rosenbaek LL et al. 2013K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl cotransporter. Am J Physiol Renal Physiol 305: F1177-F1188
36. Terker AS, Yang C-L, McCormick JA et al. Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. Hypertension 2014; 64: 178-184
37. Castaneda-Bueno M, Cervantes-Perez LG, Rojas-Vega K et al. Modulation of NCC activity by low and high K+ intake:insights into the signaling pathways involved. Am J Physiol Renal Physiol 2014; 306: F1507-F1519
38. Welling PA. Regulation of renal potassium secretion: molecular mechanisms. Semin Nephrol 2013; 33: 215-228
39. Andres R, Baltzan MA, Cader G et al. Effect of insulin on carbohydrate metabolism and on potassium in the forearm of man. J Clin Invest 1962; 41: 108-115
40. Rabinowitz D, Zierler KL. Forearm metabolism in obesity and its response to intrarterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism. J Clin Invest 1962; 41: 2173-2181
41. R Core Team (2014). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/.