Need to quickly excrete K+? Turn off NCC

Kidney International

Volumn 83, Issue 5, 2013, Pages 779-782

  McDonough, Alicia A ^a   Youn, Jang H ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; EPITHELIAL SODIUM CHANNEL; POTASSIUM; SODIUM; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN 3; THIAZIDE DIURETIC AGENT;

ALDOSTERONE BLOOD LEVEL; GITELMAN SYNDROME; HUMAN; HYPERKALEMIA; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY TUBULE ABSORPTION; NONHUMAN; POTASSIUM BALANCE; POTASSIUM BLOOD LEVEL; POTASSIUM EXCRETION; POTASSIUM INTAKE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PSEUDOHYPOALDOSTERONISM; REVIEW; SODIUM EXCRETION;

EID: 84877053217     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.468     Document Type: Note

References (10)

1. Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol 2009; 71: 381-401.
2. Nguyen MT, Yang LE, Fletcher NK et al. Effects of K\+-deficient diets with and without NaCl supplementation on Na\+, K\+, and H2O transporters' abundance along the nephron. Am J Physiol Renal Physiol 2012; 303: F92-F104.
3. Rabinowitz L. Aldosterone and potassium homeostasis. Kidney Int 1996; 49: 1738-1742.
4. Lee FN, Oh GH, McDonough AA et al. Evidence for gut factor in K\+ homeostasis. Am J Physiol Renal Physiol 2007; 293: F541-F547.
5. Oh KS, Oh YT, Kim SW et al. Gut sensing of dietary K(\+) intake increases renal K(\+)excretion. Am J Physiol Regul Integr Comp Physiol 2011; 301: R421-R429.
6. Sorensen MV, Grossmann S, Roesinger M et al. Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney Int 2013; 83: 811-824.
7. Brooks HL, Sorensen AM, Terris J et al. Profiling of renal tubule Na\+ transporter abundances in NHE3 and NCC null mice using targeted proteomics. J Physiol 2001; 530: 359-366.
8. Yang SS, Lo YF, Yu IS et al. Generation and analysis of the thiazide-sensitive Na\+-Cl-cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum Mutat 2010; 31: 1304-1315.
9. Yang SS, Morimoto T, Rai T et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/\+) knockin mouse model. Cell Metab 2007; 5: 331-344.
10. West GB, Brown JH. The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization. J Exp Biol 2005; 208: 1575-1592.