Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis

Gastric Cancer

Volumn 19, Issue 1, 2016, Pages 166-175

  Chen, Hai Ning ^a   Wang, Zhu ^a   Li, Xiao ^a   Zhou, Zong Guang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Gastric cancer; Helicobacter pylori treatment; Precancerous lesions

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; BISMUTH; BISMUTH SALICYLATE; CLARITHROMYCIN; LANSOPRAZOLE; METRONIDAZOLE; OMEPRAZOLE; PLACEBO; PROTON PUMP INHIBITOR; RABEPRAZOLE;

ARTICLE; ATROPHIC GASTRITIS; CANCER GROWTH; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; ERADICATION THERAPY; EVIDENCE BASED MEDICINE; GASTROINTESTINAL DYSPLASIA; GASTROSCOPY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; INTESTINE DYSPLASIA; INTESTINE METAPLASIA; MEDICAL HISTORY; META ANALYSIS; PATHOGEN CLEARANCE; PERSISTENT INFECTION; PRECANCER; PRIORITY JOURNAL; RISK REDUCTION; STOMACH CANCER; STOMACH SURGERY; COMPLICATION; HELICOBACTER INFECTIONS; METAPLASIA; MICROBIOLOGY; PATHOLOGY; PRECANCEROUS CONDITIONS; RANDOMIZED CONTROLLED TRIAL (TOPIC); STOMACH MUCOSA; STOMACH NEOPLASMS;

GASTRIC MUCOSA; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HUMANS; METAPLASIA; PRECANCEROUS CONDITIONS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STOMACH NEOPLASMS;

EID: 84951568020     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-015-0462-7     Document Type: Article

References (38)

1. Correa P, Fontham ET, Bravo JC, Bravo LE, Ruiz B, Zarama G, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst. 2000;92:1881–8.
2. Sung JJ, Lin SR, Ching JY, Zhou LY, To KF, Wang RT, et al. Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology. 2000;119:7–14.
3. Leung WK, Lin SR, Ching JY, To KF, Ng EK, Chan FK, et al. Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut. 2004;53:1244–9.
4. You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. 2006;98:974–83.
5. Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, et al. Management of Helicobacter pylori infection–the Maastricht IV/Florence Consensus Report. Gut. 2012;61:646–64.
6. Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet. 2008;372:392–7.
7. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA J Am Med Assoc. 2004;291:187–94.
8. Mera R, Fontham ET, Bravo LE, Bravo JC, Piazuelo MB, Camargo MC, et al. Long term follow up of patients treated for Helicobacter pylori infection. Gut. 2005;54:1536–40.
9. Wong BC, Zhang L, Ma JL, Pan KF, Li JY, Shen L, et al. Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Gut. 2012;61:812–8.
10. Choi J, Kim SG, Yoon H, Im JP, Kim JS, Kim WH, et al. Eradication of Helicobacter pylori after endoscopic resection of gastric tumors does not reduce incidence of metachronous gastric carcinoma. Clinic Gastroenterol Hepatol Off Clinical Pract J Am Gastroenterol Assoc. 2014;12(793–800):e1.
11. Correa P, Piazuelo MB. The gastric precancerous cascade. J Dig Dis. 2012;13:2–9.
12. Wang J, Xu L, Shi R, Huang X, Li SW, Huang Z, et al. Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta-analysis. Digestion. 2011;83:253–60.
13. Rokkas T, Pistiolas D, Sechopoulos P, Robotis I, Margantinis G. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis. Helicobacter. 2007;12(Suppl 2):32–8.
14. Lee YC, Chen TH, Chiu HM, Shun CT, Chiang H, Liu TY, et al. The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. Gut. 2013;62:676–82.
15. JPT H (eds) (2011) GS cochrane handbook for systematic reviews of interventions Version 5.1.0 (updated March 2011). The cochrane collaboration. 2011; Available from http://www.cochrane-handbook.org. Accessed 20 May 2014
16. Friedrich JO, Adhikari NK, Beyene J. Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data. BMC Med Res Methodol. 2007;7:5.
17. Sung JJ, Lin SR, Leung WK. Does eradication of H. pylori prevent deterioration of gastric atrophy and intestinal metaplasia? A 5-year follow-up. Gastroenterology. 2002;122:A170.
18. Ma JL, Zhang L, Brown LM, Li JY, Shen L, Pan KF, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012;104:488–92.
19. Cho SJ, Choi IJ, Kook MC, Yoon H, Park S, Kim CG, et al. Randomised clinical trial: the effects of Helicobacter pylori eradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer. Aliment Pharmacol Ther. 2013;38:477–89.
20. Ford AC, Moayyedi P. Redundant data in the meta-analysis on Helicobacter pylori eradication. Annal Int Med. 2009;151:513 (Author reply -4).
21. Yoon SB, Park JM, Lim CH, Cho YK, Choi MG. Effect of Helicobacter pylori eradication on metachronous gastric cancer after endoscopic resection of gastric tumors: a meta-analysis. Helicobacter. 2014;19:243–8.
22. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. New Engl J Med. 2001;345:784–9.
23. Kim N, Park RY, Cho SI, Lim SH, Lee KH, Lee W, et al. Helicobacter pylori infection and development of gastric cancer in Korea: long-term follow-up. J Clin Gastroenterol. 2008;42:448–54.
24. Kodama M, Murakami K, Okimoto T, Abe H, Sato R, Ogawa R, et al. Histological characteristics of gastric mucosa prior to Helicobacter pylori eradication may predict gastric cancer. Scand J Gastroenterol. 2013;48:1249–56.
25. Kim YI, Choi IJ, Kook MC, Cho SJ, Lee JY, Kim CG, et al. The association between Helicobacter pylori status and incidence of metachronous gastric cancer after endoscopic resection of early gastric cancer. Helicobacter. 2014;19:194–201.
26. Bae SE, Jung HY, Kang J, Park YS, Baek S, Jung JH, et al. Effect of Helicobacter pylori eradication on metachronous recurrence after endoscopic resection of gastric neoplasm. Am J Gastroenterol. 2014;109:60–7.
27. Jung S, Park CH, Kim EH, Shin SJ, Chung H, Lee H, et al. Helicobacter pylori eradication is insufficient to prevent metachronous gastric lesions after ESD. J Gastroenterol. Hepatol. 2014.
28. Lim JH, Kim SG, Choi J, Im JP, Kim JS, Jung HC. Risk factors for synchronous or metachronous tumor development after endoscopic resection of gastric neoplasms. Gastric Cancer Off J Int Gastric Cancer Assoc Japan Gastric Cancer Assoc. 2014.
29. Witteman EM, Mravunac M, Becx MJ, Hopman WP, Verschoor JS, Tytgat GN, et al. Improvement of gastric inflammation and resolution of epithelial damage one year after eradication of Helicobacter pylori. J Clin Pathol. 1995;48:250–6.
30. Schenk BE, Kuipers EJ, Nelis GF, Bloemena E, Thijs JC, Snel P, et al. Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy. Gut. 2000;46:615–21.
31. Miwa H, Hirai S, Nagahara A, Murai T, Nishira T, Kikuchi S, et al. Cure of Helicobacter pylori infection does not improve symptoms in non-ulcer dyspepsia patients-a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2000;14:317–24.
32. De Leest HT, Steen KS, Bloemena E, Lems WF, Kuipers EJ, Van de Laar MA, et al. Helicobacter pylori eradication in patients on long-term treatment with NSAIDs reduces the severity of gastritis: a randomized controlled trial. J Clin Gastroenterol. 2009;43:140–6.
33. Kamada T, Haruma K, Hata J, Kusunoki H, Sasaki A, Ito M, et al. The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis. Aliment Pharmacol Ther. 2003;18:245–52.
34. Befrits R, Sjostedt S, Tour R, Leijonmarck CE, Hedenborg L, Backman M, et al. Long-term effects of eradication of Helicobacter pylori on relapse and histology in gastric ulcer patients: a two-year follow-up study. Scand J Gastroenterol. 2004;39:1066–72.
35. Kuipers EJ, Nelis GF, Klinkenberg-Knol EC, Snel P, Goldfain D, Kolkman JJ, et al. Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial. Gut. 2004;53:12–20.
36. Arkkila PE, Seppala K, Farkkila MA, Veijola L, Sipponen P. Helicobacter pylori eradication in the healing of atrophic gastritis: a one-year prospective study. Scand J Gastroenterol. 2006;41:782–90.
37. Zullo A, Rinaldi V, Hassan C, Diana F, Winn S, Castagna G, et al. Ascorbic acid and intestinal metaplasia in the stomach: a prospective, randomized study. Aliment Pharmacol Ther. 2000;14:1303–9.
38. Ruiz B, Garay J, Correa P, Fontham ET, Bravo JC, Bravo LE, et al. Morphometric evaluation of gastric antral atrophy: improvement after cure of Helicobacter pylori infection. Am J Gastroenterol. 2001;96:3281–7.