Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: A randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study)

British Journal of Nutrition

Volumn 115, Issue 2, 2016, Pages 271-284

  Putet, Guy ^a,b   Labaune, Jean Marc ^a   Mace, Katherine ^c   Steenhout, Philippe ^c   Grathwohl, Dominik ^c   Raverot, Veronique ^d   Morel, Yves ^d   Picaud, Jean Charles ^a,b,e  

^a CROIX ROUSSE HOSPITAL   (France)

^b UNIVERSITÉ LYON 1   (France)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

^d HOSPICES CIVILS DE LYON   (France)

^e CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

Dietary proteins; Fat mass; Growth; Infants; Obesity

Indexed keywords

SOMATOMEDIN C; IGF1 PROTEIN, HUMAN; PROTEIN INTAKE;

ANTHROPOMETRIC PARAMETERS; ARTICLE; ARTIFICIAL MILK; BLOOD LEVEL; BODY COMPOSITION; BODY HEIGHT; BODY WEIGHT; BREAST FEEDING; CHILD GROWTH; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GROWTH RATE; HEAD CIRCUMFERENCE; HUMAN; INFANCY; INFANT; MALE; OUTCOME ASSESSMENT; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; ADMINISTRATION AND DOSAGE; ANTHROPOMETRY; GROWTH; NEWBORN; OBESITY;

ANTHROPOMETRY; BODY COMPOSITION; BODY HEIGHT; BODY WEIGHT; BREAST FEEDING; DIETARY PROTEINS; DOUBLE-BLIND METHOD; GROWTH; HUMANS; INFANT; INFANT FORMULA; INFANT, NEWBORN; INSULIN-LIKE GROWTH FACTOR I; OBESITY;

EID: 84951558920     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515004456     Document Type: Article

References (50)

1. Baird J, Fisher D, Lucas P, et al. (2005) Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ 331, 929.
2. Karaolis-Danckert N, Buyken AE, Bolzenius K, et al. (2006) Rapid growth among term children whose birth weight was appropriate for gestational age has a longer lasting effect on body fat percentage than on body mass index. Am J Clin Nutr 84, 1449-1455.
3. Taveras EM, Rifas-Shiman SL, Belfort MB, et al. (2009) Weight status in the first 6 months of life and obesity at 3 years of age. Pediatrics 123, 1177-1183.
4. Ong KK, Emmett PM, Noble S, et al. (2006) Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics 117, e503-E508.
5. Druet C, Stettler N, Sharp S, et al. (2012) Prediction of childhood obesity by infancy weight gain: an individual-level metaanalysis. Paediatr Perinat Epidemiol 26, 19-26.
6. Heinig MJ, Nommsen LA, Peerson JM, et al. (1993) Energy and protein intakes of breast-fed and formula-fed infants during the first year of life and their association with growth velocity: the DARLING Study. Am J Clin Nutr 58, 152-161.
7. Nielsen GA, Thomsen BL, & Michaelsen KF (1998) Influence of breastfeeding and complementary food on growth between 5 and 10 months. Acta Paediatr 87, 911-917.
8. Axelsson IE, Ivarsson SA, & Raiha NC (1989) Protein intake in early infancy: effects on plasma amino acid concentrations, insulin metabolism, and growth. Pediatr Res 26, 614-617.
9. Raiha N, Minoli I, & Moro G (1986) Milk protein intake in the term infant. I. Metabolic responses and effects on growth. Acta Paediatr Scand 75, 881-886.
10. Koletzko B, von Kries R, Closa R, et al. (2009) Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr 89, 1836-1845.
11. Akeson PM, Axelsson IE, & Raiha NC (1998) Growth and nutrient intake in three-to twelve-month-old infants fed human milk or formulas with varying protein concentrations. J Pediatr Gastroenterol Nutr 26, 1-8.
12. Gunnarsdottir I, & Thorsdottir I (2003) Relationship between growth and feeding in infancy and body mass index at the age of 6 years. Int J Obes Relat Metab Disord 27, 1523-1527.
13. Rolland-Cachera MF, Deheeger M, Akrout M, et al. (1995) Influence of macronutrients on adiposity development: a follow up study of nutrition and growth from 10 months to 8 years of age. Int J Obes Relat Metab Disord 19, 573-578.
14. Scaglioni S, Agostoni C, Notaris RD, et al. (2000) Early macronutrient intake and overweight at five years of age. Int J Obes Relat Metab Disord 24, 777-781.
15. Dorosty AR, Emmett PM, Cowin S, et al. (2000) Factors associated with early adiposity rebound. ALSPAC Study Team. Pediatrics 105, 1115-1118.
16. Hoppe C, Molgaard C, Thomsen BL, et al. (2004) Protein intake at 9 mo of age is associated with body size but not with body fat in 10-y-old Danish children. Am J Clin Nutr 79, 494-501.
17. Koletzko B, Broekaert I, Demmelmair H, et al. (2005) Protein intake in the first year of life: a risk factor for later obesity?. The E.U. childhood obesity project. Adv Exp Med Biol 569, 69-79.
18. Koletzko B, von Kries R, Closa R, et al. (2009) Can infant feeding choices modulate later obesity risk?. Am J Clin Nutr 89, 1502S-1508S.
19. The Commission of European Communities (2006) Commission Directive 2006/141/EC of 22 December 2006 on infant formulae and follow-on formulae and amending Directive 1999/21/EC. Off J Eur Union L401/1, 1-33.
20. Chouraqui JP, Grathwohl D, Labaune JM, et al. (2008) Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am J Clin Nutr 87, 1365-1373.
21. Koo WW, Walters J, & Bush AJ (1995) Technical considerations of dual-Energy X-ray absorptiometry-based bone mineral measurements for pediatric studies. J Bone Miner Res 10, 1998-2004.
22. Mace K, Steenhout P, Klassen P, et al. (2006) Protein quality and quantity in cow's milk-based formula for healthy term infants: past, present and future. Nestle Nutr Inst Workshop Ser Pediatr Program 58, 189-203.
23. World Health Organization Multicentre Growth Reference Study Group (2006) WHO Child Growth Standards: Length/Height-for-Age, Weight-for-Age, Weight-for-Length, Weightfor-Height and Body Mass Index-for-Age: Methods and Development. Geneva: WHO.
24. Fleddermann M, Demmelmair H, Grote V, et al. (2014) Infant formula composition affects energetic efficiency for growth: The BeMIM study, a randomized controlled trial. Clin Nutr 33, 588-595.
25. Socha P, Grote V, Gruszfeld D, et al. (2011) Milk protein intake, the metabolic-Endocrine response, and growth in infancy: data from a randomized clinical trial. Am J Clin Nutr 94, 1776S-1784S.
26. Ong KK, Langkamp M, Ranke MB, et al. (2009) Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study. Am J Clin Nutr 90, 156-161.
27. Larnkjaer A, Hoppe C, Molgaard C, et al. (2009) The effects of whole milk and infant formula on growth and IGF-I in late infancy. Eur J Clin Nutr 63, 956-963.
28. Savino F, Nanni GE, Maccario S, et al. (2005) Relationships between IGF-I and weight Z score, BMI, tricipital skin-fold thickness, type of feeding in healthy infants in the first 5 months of life. Ann Nutr Metab 49, 83-87.
29. Socha P, Janas R, Dobrzanska A, et al. (2005) Insulin like growth factor regulation of body mass in breastfed and milk formula fed infants. Data from the E.U. Childhood Obesity Programme. Adv Exp Med Biol 569, 159-163.
30. Madsen AL, Larnkjaær A, Mølgaard C, et al. (2011) IGF-I and IGFBP-3 in healthy 9 month old infants from the SKOT cohort: breastfeeding, diet, and later obesity. Growth Horm IGF Res 21, 199-204.
31. Diaz-Gomez NM, Domenech E, & Barroso F (1997) Breastfeeding and growth factors in preterm newborn infants. J Pediatr Gastroenterol Nutr 24, 322-327.
32. Martin RM, Holly JM, Smith GD, et al. (2005) Could associations between breastfeeding and insulin-like growth factors underlie associations of breastfeeding with adult chronic disease?. The Avon Longitudinal Study of Parents and Children. Clin Endocrinol (Oxf) 62, 728-737.
33. Hoppe C, Mølgaard C, Dalum C, et al. (2009) Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-Day supplementation study in prepubertal boys. Eur J Clin Nutr 63, 1076-1083.
34. Michaelsen KF, & Greer FR (2014) Protein needs early in life and long-Term health. Am J Clin Nutr 99, 718S-722S.
35. Savino F, Fissore MF, Grassino EC, et al. (2005) Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. Acta Paediatr 94, 531-537.
36. Larnkjaer A, Ingstrup HK, Schack-Nielsen L, et al. (2009) Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects. Growth Horm IGF Res 19, 82-86.
37. Juul A, Scheike T, Davidsen M, et al. (2002) Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation 106, 939-944.
38. Kon IY, Shilina NM, Gmoshinskaya MV, et al. (2014) The study of breast milk IGF-1, leptin, ghrelin and adiponectin levels as possible reasons of high weight gain in breast-fed infants. Ann Nutr Metab 65, 317-323.
39. Donovan SM, Chao JC, Zijlstra RT, et al. (1997) Orally administered iodinated recombinant human insulin-like growth factor-I (125I-rhIGF-I) is poorly absorbed by the newborn piglet. J Pediatr Gastroenterol Nutr 24, 174-182.
40. Burrin DG, Davis TA, Fiorotto ML, et al. (1997) Role of milk-borne vs endogenous insulin-like growth factor I in neonatal growth. J Anim Sci 75, 2739-2743.
41. Ginsburg BE, Lindblad BS, Lundsjö A, et al. (1984) Plasma valine and urinary C-peptide in breast-fed and artificially fed infants up to 6 months of age. Acta Paediatr Scand 73, 213-217.
42. Closa-Monasterolo R, Ferre N, Luque V, et al. (2011) Sex differences in the endocrine system in response to protein intake early in life. Am J Clin Nutr 9, 1920S-1927S.
43. Weber M, Grote V, Closa-Monasterolo R, et al. (2014) Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr 99, 1041-1051.
44. Escribano J, Luque V, Ferre N, et al. (2011) Increased protein intake augments kidney volume and function in healthy infants. Kidney Int 79, 783-790.
45. Salmenperä L, Perheentupa J, & Siimes MA (1985) Exclusively breast-fed healthy infants grow slower than reference infants. Pediatr Res 19, 307-312.
46. Timby N, Domellöf E, Hernell O, et al. (2014) Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-Energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 99, 860-868.
47. Júlíusson PB, Roelants M, Nordal E, et al. (2013) Growth references for 0-19 year-old Norwegian children for length/height, weight, body mass index and head circumference. Ann Hum Biol 40, 220-227.
48. Saarela T, Kokkonen J, & Koivisto M (2005) Macronutrient and energy contents of human milk fractions during the first six months of lactation. Acta Paediatr 94, 1176-1181.
49. Butte NF, Wong WW, Hopkinson JM, et al. (2000) Energy requirements derived from total energy expenditure and energy deposition during the first 2 y of life. Am J Clin Nutr 72, 1558-1569.
50. Escribano J, Luque V, Ferre N, et al. (2012) Effect of protein intake and weight gain velocity on body fat mass at 6 months of age: the EU Childhood Obesity Programme. Int J Obes (Lond) 36, 548-553.