Neomycin and bacitracin reduce the intestinal permeability in mice and increase the expression of some tight-junction proteins;La neomicina y bacitracina disminuyen la permeabilidad intestinal en ratones e incrementan la expresión de algunas proteínas de unión estrecha

Revista Espanola de Enfermedades Digestivas

Volumn 107, Issue 11, 2015, Pages 672-676

  Nevado, Rebeca ^a   Forcén, Raquel ^a   Layunta, Elena ^a   Murillo, María Divina ^a,b   Grasa, Laura ^a,b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b INSTITUTO DE INVESTIGACIÓN SANITARIA ARAGÓN IIS ARAGÓN   (Spain)

Author keywords

Antibiotics; Intestinal permeability; Microbiota; Tight junction proteins

Indexed keywords

BACITRACIN; CLAUDIN 3; CLAUDIN 4; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; JUNCTIONAL ADHESION MOLECULE A; MESSENGER RNA; NEOMYCIN; OCCLUDIN; PROTEIN ZO1; TIGHT JUNCTION PROTEIN; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; INTESTINE MUCOSA PERMEABILITY; MICROFLORA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; INTESTINE; INTESTINE ABSORPTION; METABOLISM; PERMEABILITY;

ANIMALS; ANTI-BACTERIAL AGENTS; BACITRACIN; GENE EXPRESSION; INTESTINAL ABSORPTION; INTESTINES; MICE; NEOMYCIN; PERMEABILITY; TIGHT JUNCTION PROTEINS;

EID: 84951154834     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: 10.17235/reed.2015.3868/2015     Document Type: Article

References (22)

1. Suzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci 2013; 70: 631-59. DOI: 10.1007/s00018-012-1070-x
2. Camilleri M, Madsen K, Spiller R, et al. Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterol Motil 2012; 24: 503-12. DOI: 10.1111/j.1365-2982.2012.01921. x
3. Bricker E, Garg R, Nelson R, et al. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst Rev 2005 CD004610.
4. Nelson R. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst Rev 2007: CD004610.
5. Cannon JA, Altom LK, Deierhoi RJ, et al. Preoperative oral antibiotics reduce surgical site infection following elective colorectal resections. Dis Colon Rectum 2012; 55: 1160-6. DOI: 10.1097/DCR.0b013e3182684fac
6. DiPiro JT, Patrias JM, Townsend RJ, et al. Oral neomycin sulfate and erythromycin base before colon surgery: A comparison of serum and tissue concentrations. Pharmacotherapy 1985; 5: 91-4.
7. Eltawil KM, Laryea M, Peltekian K, et al. Rifaximin vs. conventional oral therapy for hepatic encephalopathy: A meta-analysis. World J Gastroenterol 2012; 18: 767-77. DOI: 10.3748/wjg. v18. i8.767
8. Alimonti A, Satta F, Pavese I, et al. Prevention of irinotecan plus 5-fluorouracil/leucovorin-induced diarrhoea by oral administration of neomycin plus bacitracin in first-line treatment of advanced colorectal cancer. Ann Oncol 2003; 14: 805-6. DOI: 10.1093/annonc/mdg193
9. Spiller R, Lam C. The shifting interface between IBS and IBD. Curr Opin Pharmacol 2011; 11: 586-92. DOI: 10.1016/j. coph.2011.09.009
10. Grasa L, Abecia L, Forcen R, et al. Antibiotic-induced depletion of murine microbiota induces mild inflammation and changes in toll-like receptor patterns and intestinal motility. Microb Ecol 2015; 70: 835-48.
11. Patel RM, Myers LS, Kurundkar AR, et al. Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol 2012; 180: 626-35. DOI: 10.1016/j. ajpath.2011.10.025
12. Ren T, Grants I, Alhaj M, et al. Impact of disrupting adenosine A(3) receptors (A(3)(-)/(-) AR) on colonic motility or progression of colitis in the mouse. Inflamm Bowel Dis 2011; 17: 1698-713. DOI: 10.1002/ibd.21553
13. Fujita T, Kawahara I, Quan Y, et al. Permeability characteristics of tetragastrins across intestinal membranes using the Caco-2 monolayer system: Comparison between acylation and application of protease inhibitors. Pharm Res 1998; 15: 1387-92. DOI: 10.1023/A: 1011997404306
14. Rull S, Ponz F. [Effects of neomicine on the transport of sugars by rat and hamster small intestine (author's transl)]. Rev Esp Fisiol 1974; 30: 183-90.
15. De Lisle RC, Mueller R, Boyd M. Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse. J Pediatr Gastroenterol Nutr 2011; 53: 371-9. DOI: 10.1097/MPG.0b013e318219c397
16. Xu D, Gao J, Gillilland M, 3rd, et al. Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats. Gastroenterology 2014; 146: 484-96 e4. DOI: 10.1053/j. gastro.2013.10.026
17. Holmes JL, Van Itallie CM, Rasmussen JE, et al. Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr Patterns 2006; 6: 581-8. DOI: 10.1016/j. modgep.2005.12.001
18. Laukoetter MG, Nava P, Lee WY, et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med 2007; 204: 3067-76. DOI: 10.1084/jem.20071416
19. Al-Sadi R, Khatib K, Guo S, et al. Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 2011; 300: G1054-64. DOI: 10.1152/ajpgi.00055.2011
20. Liu H, Wang P, Cao M, et al. Protective role of oligomycin against intestinal epithelial barrier dysfunction caused by IFN-gamma and TNF-alpha. Cell Physiol Biochem 2012; 29: 799-808. DOI: 10.1159/000188076
21. Garrido-Mesa N, Utrilla P, Comalada M, et al. The association of minocycline and the probiotic Escherichia coli Nissle 1917 results in an additive beneficial effect in a DSS model of reactivated colitis in mice. Biochem Pharmacol 2011; 82: 1891-900. DOI: 10.1016/j. bcp.2011.09.004
22. Hwang I, An BS, Yang H, et al. Tissue-specific expression of occludin, zone occludens-1, and junction adhesion molecule A in the duodenum, ileum, colon, kidney, liver, lung, brain, and skeletal muscle of C57BL mice. J Physiol Pharmacol 2013; 64: 11-8.