Linagliptin limits high glucose induced conversion of latent to active TGFβ through interaction with CIM6PR and limits renal tubulointerstitial fibronectin

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Komala, Muralikrishna Gangadharan ^a   Gross, Simon ^a   Zaky, Amgad ^a   Pollock, Carol ^a   Panchapakesan, Usha ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRONECTIN; INSULIN GLARGINE; LINAGLIPTIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SOMATOMEDIN B RECEPTOR; TELMISARTAN; TRANSFORMING GROWTH FACTOR BETA; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TUBULE; KIDNEY TUBULE DISORDER; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; TREATMENT RESPONSE; ANIMAL; CELL LINE; DRUG EFFECTS; KIDNEY; KIDNEY PROXIMAL TUBULE; METABOLISM; MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; FIBRONECTINS; GLUCOSE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TUBULES, PROXIMAL; LINAGLIPTIN; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84951041234     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0141143     Document Type: Article

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