EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

European Journal of Pharmaceutical Sciences

Volumn 83, Issue , 2016, Pages 28-35

  Xie, Xiaodong ^a   Li, Fengqiao ^a   Zhang, Huijuan ^a   Lu, Yusheng ^a   Lian, Shu ^a   Lin, Hang ^a   Gao, Yu ^a   Jia, Lee ^a  

^a FUZHOU UNIVERSITY   (China)

Author keywords

Aptamer; Doxorubicin; EpCAM; Mesoporous silica nanoparticle; Targeted drug delivery

Indexed keywords

APTAMER; DOXORUBICIN; EPITHELIAL CELL ADHESION MOLECULE; MESOPOROUS SILICA NANOPARTICLE; ANTINEOPLASTIC ANTIBIOTIC; NANOPARTICLE; SILICON DIOXIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL TRANSPORT; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; HUMAN CELL; NANOENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; ZETA POTENTIAL; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; GENETICS; METABOLISM; POROSITY; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; APTAMERS, NUCLEOTIDE; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; EPITHELIAL CELL ADHESION MOLECULE; HUMANS; NANOPARTICLES; POROSITY; SILICON DIOXIDE;

EID: 84950250969     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.12.014     Document Type: Article

References (47)

1. N. Ababneh, W. Alshaer, O. Allozi, A. Mahafzah, M. El-Khateeb, H. Hillaireau, M. Noiray, E. Fattal, and S. Ismail In vitro selection of modified RNA aptamers against CD44 cancer stem cell marker Nucleic Acid Ther. 23 2013 401 407
2. M. Alibolandi, M. Ramezani, K. Abnous, F. Sadeghi, F. Atyabi, M. Asouri, A.A. Ahmadi, and F. Hadizadeh In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer J. Control. Release 209 2015 88 100
3. A. Bose, A. Elyagoby, and T.W. Wong Oral 5-fluorouracil colon-specific delivery through in vivo pellet coating for colon cancer and aberrant crypt foci treatment Int. J. Pharm. 468 2014 178 186
4. H. Cao, E. Xu, H. Liu, L. Wan, and M. Lai Epithelial-mesenchymal transition in colorectal cancer metastasis: a system review Pathol. Res. Pract. 211 2015 557 569
5. C. Chittasupho, K. Lirdprapamongkol, P. Kewsuwan, and N. Sarisuta Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles Eur. J. Pharm. Biopharm. 88 2014 529 538
6. S. Chung, M. Cho, J. Hwan Jung, and T. Seok Seo Highly sensitive detection of cancer cells based on the DNA barcode assay and microcapillary electrophoretic analysis Electrophoresis 35 2014 1504 1508
7. A. Corti, F. Pastorino, F. Curnis, W. Arap, M. Ponzoni, and R. Pasqualini Targeted drug delivery and penetration into solid tumors Med. Res. Rev. 32 2012 1078 1091
8. I. Cossu, G. Bottoni, M. Loi, L. Emionite, A. Bartolini, D. Di Paolo, C. Brignole, F. Piaggio, P. Perri, A. Sacchi, F. Curnis, M.C. Gagliani, S. Bruno, C. Marini, A. Gori, R. Longhi, D. Murgia, A.R. Sementa, M. Cilli, C. Tacchetti, A. Corti, G. Sambuceti, S. Marchiò, M. Ponzoni, and F. Pastorino Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion Biomaterials 68 2015 89 99
9. M. Das, W. Duan, and S.K. Sahoo Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy Nanomed: Nanotechnol. Biol. Med. 11 2015 379 389
10. S.D. Dorothea Maetzel, B. Mack, M. Canis, P. Went, and M. Benk Nuclear signalling by tumour-associated antigen EpCAM Nat. Cell Biol. 11 2009 162 171
11. Q. Gao, Q. Liang, F. Yu, J. Xu, Q. Zhao, and B. Sun Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system Colloids Surf. B Biointerfaces 88 2011 741 748
12. G. Gastl, G. Spizzo, P. Obrist, M. Dünser, and G. Mikuz Ep-CAM overexpression in breast cancer as a predictor of survival Lancet 356 2000 1981 1982
13. M. Hajrezaie, K. Shams, S.Z. Moghadamtousi, H. Karimian, P. Hassandarvish, M. Emtyazjoo, M. Zahedifard, N.A. Majid, H.M. Ali, and M.A. Abdulla Chemoprevention of colonic aberrant crypt foci by novel Schiff based dichlorido(4-methoxy-2-{[2-(piperazin-4-Ium-1-Yl)ethyl]iminomethyl}phenolate)Cd complex in azoxymethane-induced colorectal cancer in rats Sci. Rep. 5 2015 12379
14. Q. He, and J. Shi MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition Adv. Mater. 26 2014 391 411
15. H. Sun, and Y. Zu A highlight of recent advances in aptamer technology and its application Molecules 20 2015 11959 11980
16. N. Hugen, G. Brown, R. Glynne-Jones, J.H. de Wilt, and I.D. Nagtegaal Advances in the care of patients with mucinous colorectal cancer Nat. Rev. Clin. Oncol. 2015
17. J. Shen, Q. He, G. Yu, J. Shi, and Y. Li Mesoporous silica nanoparticles loading doxorubicin reverse multidrug resistance: performance and mechanism Nanoscale 3 2011 4314 4322
18. D.H. Kwak, J.S. Ryu, C.H. Kim, K. Ko, J.Y. Ma, K.A. Hwang, and Y.K. Choo Relationship between ganglioside expression and anti-cancer effects of the monoclonal antibody against epithelial cell adhesion molecule in colon cancer Exp. Mol. Med. 43 2011 693 701
19. W.M. Li, T. Bing, J.Y. Wei, Z.Z. Chen, D.H. Shangguan, and J. Fang Cell-SELEX-based selection of aptamers that recognize distinct targets on metastatic colorectal cancer cells Biomaterials 35 2014 6998 7007
20. S. Maya, B. Sarmento, V.-K. Lakshmanan, D. Menon, and R. Jayakumar Actively targeted cetuximab conjugated γ-poly(glutamic acid)-docetaxel nanomedicines for epidermal growth factor receptor over expressing colon cancer cells J. Biomed. Nanotechnol. 10 2014 1416 1428
21. M. Munz, P.A. Baeuerle, and O. Gires The emerging role of EpCAM in cancer and stem cell signaling Cancer Res. 69 2009 5627 5629
22. M. Munz, C. Kieu, B. Mack, B. Schmitt, R. Zeidler, and O. Gires The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation Oncogene 23 2004 5748 5758
23. T. Nubel, J. Preobraschenski, H. Tuncay, T. Weiss, S. Kuhn, M. Ladwein, L. Langbein, and M. Zoller Claudin-7 regulates EpCAM-mediated functions in tumor progression Mol. Cancer Res. 7 2009 285 299
24. A. Ojima, T. Matsui, S. Maeda, M. Takeuchi, H. Inoue, Y. Higashimoto, and S. Yamagishi DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice Lab. Investig. 94 2014 422 429
25. L. Pan, Q. He, J. Liu, Y. Chen, M. Ma, L. Zhang, and J. Shi Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles J. Am. Chem. Soc. 134 2012 5722 5725
26. C. Patriarca, R.M. Macchi, A.K. Marschner, and H. Mellstedt Epithelial cell adhesion molecule expression (CD326) in cancer: a short review Cancer Treat. Rev. 38 2012 68 75
27. X. Pei, J. Zhang, and J. Liu Clinical applications of nucleic acid aptamers in cancer Mol. Clin. Oncol. 2 2014 341 348
28. D. Ponti, N. Zaffaroni, C. Capelli, and M.G. Daidone Breast cancer stem cells: an overview Eur. J. Cancer 42 2006 1219 1224
29. L. Ricci-Vitiani, D.G. Lombardi, E. Pilozzi, M. Biffoni, M. Todaro, C. Peschle, and R. De Maria Identification and expansion of human colon-cancer-initiating cells Nature 445 2007 111 115
30. K. Sefah, L. Meng, D. Lopez-Colon, E. Jimenez, C. Liu, and W. Tan DNA aptamers as molecular probes for colorectal cancer study PLoS ONE 5 2010 e14269
31. Q. Shen, L. Xu, L. Zhao, D. Wu, Y. Fan, Y. Zhou, W.H. Ouyang, X. Xu, Z. Zhang, M. Song, T. Lee, M.A. Garcia, B. Xiong, S. Hou, H.R. Tseng, and X. Fang Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates Adv. Mater. 25 2013 2368 2373
32. R.L. Siegel, K.D. Miller, and A. Jemal Cancer statistics, 2015 CA Cancer J. Clin. 65 2015 5 29
33. A. Somasunderam, V. Thiviyanathan, T. Tanaka, X. Li, M. Neerathilingam, G.L. Lokesh, A. Mann, Y. Peng, M. Ferrari, J. Klostergaard, and D.G. Gorenstein Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44 Biochemistry 49 2010 9106 9112
34. N. Song, and Y.W. Yang Molecular and supramolecular switches on mesoporous silica nanoparticles Chem. Soc. Rev. 44 2015 3474 3504
35. Y. Song, Z. Zhu, Y. An, W. Zhang, H. Zhang, D. Liu, C. Yu, W. Duan, and C.J. Yang Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture Anal. Chem. 85 2013 4141 4149
36. N. Subramanian, J.R. Kanwar, R.K. Kanwar, J. Sreemanthula, J. Biswas, V. Khetan, and S. Krishnakumar EpCAM aptamer-siRNA chimera targets and regress epithelial cancer PLoS ONE 10 2015 e0132407
37. F. Tang, L. Li, and D. Chen Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery Adv. Mater. 24 2012 1504 1534
38. Y. Tang, Z. Teng, Y. Liu, Y. Tian, J. Sun, S. Wang, C. Wang, J. Wang, and G. Lu Cytochrome C capped mesoporous silica nanocarriers for pH-sensitive and sustained drug release J. Mater. Chem B 2 2014 4356
39. J.E. Visvader, and G.J.L Cancer stem cells in solid tumours: accumulating evidence and unresolved questions Nat. Rev. Cancer 8 2008 755 768
40. L.B. Vong, T. Yoshitomi, H. Matsui, and Y. Nagasaki Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer Biomaterials 55 2015 54 63
41. H. Wang, P. Agarwal, S. Zhao, R.X. Xu, J. Yu, X. Lu, and X. He Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells Biomaterials 72 2015 74 89
42. J. Wang, K. Sefah, M.B. Altman, T. Chen, M. You, Z. Zhao, C.Z. Huang, and W. Tan Aptamer-conjugated nanorods for targeted photothermal therapy of prostate cancer stem cells Chem. Asian. J. 8 2013 2417 2422
43. J. Xie, Y. Lu, H. Dong, R. Zhao, H. Chen, W. Shen, P.J. Sinko, Y. Zhu, J. Wang, J. Shao, Y. Gao, F. Xie, and L. Jia Enhanced specificity in capturing and restraining circulating tumor cells with dual antibody-dendrimer conjugates Adv. Funct. Mater. 25 2015 1304 1313
44. N. Yang, Y. Jiang, H. Zhang, B. Sun, C. Hou, J. Zheng, Y. Liu, and P. Zuo Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis Mol. Pharm. 12 2015 232 239
45. X. Yao, L. Chen, X. Chen, Z. Zhang, H. Zheng, C. He, J. Zhang, and X. Chen Intracellular pH-sensitive metallo-supramolecular nanogels for anticancer drug delivery ACS Appl. Mater. Interfaces 6 2014 7816 7822
46. J. Zhou, and J.J. Rossi Cell-type-specific, aptamer-functionalized agents for targeted disease therapy Mol. Ther. Nucleic Acids 3 2014 e169
47. B. Zhou, and B. Wang Pegaptanib for the treatment of age-related macular degeneration. Exp Eye Res 83 2006 615 619