Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation

British Journal of Nutrition

Volumn 103, Issue 2, 2010, Pages 243-248

  Sjoberg, Nicholas J ^a   Milte, Catherine M ^a,b   Buckley, Jonathan D ^b   Howe, Peter R C ^b   Coates, Alison M ^b   Saint, David A ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Cardiac autonomic balance; Cardiovascular health; DHA; N 3 PUFA

Indexed keywords

BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; PLACEBO;

ADULT; ARTERY COMPLIANCE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE MEASUREMENT; BODY MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG MECHANISM; FEMALE; HEART RATE VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; ARTERY; BLOOD PRESSURE; DRUG EFFECT; HEART RATE; MIDDLE AGED; PATHOPHYSIOLOGY; PATIENT SELECTION; PHYSIOLOGY;

ADULT; ARTERIES; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BODY MASS INDEX; DIETARY SUPPLEMENTS; FEMALE; FISH OILS; HEART RATE; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PATIENT SELECTION;

EID: 84950170870     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711450999153X     Document Type: Article

References (32)

1. Kannel WB, Kannel C, Paffenbarger RS, et al. (1987) Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J 113, 1489-1494.
2. Balanescu S, Corlan AD, Dorobantu M, et al. (2004) Prognostic value of heart rate variability after acute myocardial infarction. Med Sci Monit 10, CR307-CR315.
3. Dekker JM, Schouten EG, Klootwijk P, et al. (1997) Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. Am J Epidemiol 145, 899-908.
4. Cernes R, Zimlichman R & Shargorodsky M (2008) Arterial elasticity in cardiovascular disease: focus on hypertension, metabolic syndrome and diabetes. Adv Cardiol 45, 65-81.
5. Neutel JM, Smith DH, Graettinger WF, et al. (1992) Dependency of arterial compliance on circulating neuroendocrine and metabolic factors in normal subjects. Am J Cardiol 69, 1340-1344.
6. Greiser KH, Kluttig A, Schumann B, et al. (2009) Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002-2006. Eur J Epidemiol 24, 123-142.
7. Jeppesen J, Hein HO, Suadicani P, et al. (1998) Triglyceride concentration and ischemic heart disease: an eight-year follow-up in the Copenhagen Male Study. Circulation 97, 1029-1036.
8. Assmann G, Schulte H & von Eckardstein A (1996) Hypertri-glyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men. Am J Cardiol 77, 1179-1184.
9. Laederach-Hofmann K, Mussgay L & Ruddel H (2000) Auto-nomic cardiovascular regulation in obesity. J Endocrinol 164, 59-66.
10. Matsumoto T, Miyawaki T, Ue H, et al. (1999) Autonomic responsiveness to acute cold exposure in obese and non-obese young women. Int J Obes Relat Metab Disord 23, 793-800.
11. Spraul M, Ravussin E, Fontvieille AM, et al. (1993) Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. J Clin Invest 92, 1730-1735.
12. Troisi RJ, Weiss ST, Parker DR, et al. (1991) Relation of obesity and diet to sympathetic nervous system activity. Hypertension 17, 669-677.
13. Acree LS, Montgomery PS & Gardner AW (2007) The influence of obesity on arterial compliance in adult men and women. Vasc Med 12, 183-188.
14. Glasser SP (2000) On arterial physiology, pathophysiology of vascular compliance, and cardiovascular disease. Heart Dis 2, 375-379.
15. Mehta JL, Lopez LM, Lawson D, et al. (1988) Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. Effects on indices of platelet and neutrophil function and exercise performance. Am J Med 84, 45-52.
16. Mozaffarian D, Geelen A, Brouwer IA, et al. (2005) Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation 112, 1945-1952.
17. Christensen JH, Christensen MS, Dyerberg J, et al. (1999) Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids. Am J Clin Nutr 70, 331-337.
18. Villa B, Calabresi L, Chiesa G, et al. (2002) Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease. Pharmacol Res 45, 475.
19. Ninio DM, Hill AM, Howe PR, et al. (2008) Docosahexaenoic acid-rich fish oil improves heart rate variability and heart rate responses to exercise in overweight adults. Br J Nutr 100, 1-7.
20. Calder PC (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci (Lond) 107, 1-11.
21. Milte CM, Coates AM, Buckley JD, et al. (2008) Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. Br J Nutr 99, 1083-1088.
22. Prisant LM, Pasi M, Jupin D, et al. (2002) Assessment of repeatability and correlates of arterial compliance. Blood Press Monit 7, 231-235.
23. Malik M (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93, 1043-1065.
24. Herrington DM, Kesler K, Reiber JC, et al. (2003) Arterial compliance adds to conventional risk factors for prediction of angio-graphic coronary artery disease. Am Heart J 146, 662-667.
25. Fox K, Ford I, Steg PG, et al. (2008) Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet 372, 807-816.
26. Nestel P, Shige H, Pomeroy S, et al. (2002) The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 76, 326-330.
27. McVeigh GE, Brennan GM, Cohn JN, et al. (1994) Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arterioscler Thromb 14, 1425-1429.
28. Yokoyama M, Origasa H, Matsuzaki M, et al. (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholes-terolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369, 1090-1098.
29. Metcalf RG, James MJ, Gibson RA, et al. (2007) Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr 85, 1222-1228.
30. Ninio DM, Murphy KJ, Howe PR, et al. (2005) Dietary fish oil protects against stretch-induced vulnerability to atrial fibrillation in a rabbit model. J Cardiovasc Electrophysiol 16, 1189-1194.
31. Kang JX & Leaf A (1994) Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Proc Natl Acad Sci USA 91, 9886-9890.
32. Gudbjarnason S & Hallgrimsson J (1976) Prostaglandins and polyunsaturated fatty acids in heart muscle. Acta Biol Med Ger 35, 1069-1080.