Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion

Stroke

Volumn 47, Issue 2, 2016, Pages 542-547

  Choi, Bo Ryoung ^a   Kim, Dong Hee ^a   Back, Dong Bin ^a   Kang, Chung Hwan ^a   Moon, Won Jin ^a   Han, Jung Soo ^a   Choi, Dong Hee ^a   Kwon, Kyoung Ja ^a   Shin, Chan Young ^a   Kim, Bo Ram ^a   Lee, Jongmin ^a   Han, Seol Heui ^a   Kim, Hahn Young ^a  

^a Konkuk University School of Medicine   (South Korea)

Author keywords

Cilostazol; Dementia, vascular; Models, animal; White matter

Indexed keywords

CILOSTAZOL; MYELIN BASIC PROTEIN; NEUROPROTECTIVE AGENT; TETRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN PERFUSION; CHRONIC CEREBRAL HYPOPERFUSION; COGNITIVE DEFECT; COMMON CAROTID ARTERY; CORPUS CALLOSUM; DIFFUSION TENSOR IMAGING; EXTERNAL CAPSULE; FRACTIONAL ANISOTROPY; HIPPOCAMPUS; HISTOLOGY; MORRIS WATER MAZE TEST; MULTIINFARCT DEMENTIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OLFACTORY DISCRIMINATION; OLIGODENDROGLIA; OPTIC CHIASM; PRIORITY JOURNAL; RANVIER NODE; RAT; TASK PERFORMANCE; WHITE MATTER INJURY; WISTAR RAT; ANIMAL; ANIMAL BEHAVIOR; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CHRONIC DISEASE; COGNITION; COMPLICATION; DEMENTIA, VASCULAR; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; LEUKOENCEPHALOPATHIES; METABOLISM; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; WHITE MATTER;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN ISCHEMIA; CAROTID STENOSIS; CHRONIC DISEASE; COGNITION; DEMENTIA, VASCULAR; DIFFUSION TENSOR IMAGING; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; INFLAMMATION; LEUKOENCEPHALOPATHIES; MYELIN BASIC PROTEIN; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; OLIGODENDROGLIA; RANVIER'S NODES; RATS; RATS, WISTAR; TETRAZOLES; WHITE MATTER;

EID: 84950108722     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.115.011679     Document Type: Article

References (15)

1. Norrving B. Evolving concept of small vessel disease through advanced brain imaging. J Stroke. 2015;17:94-100. doi: 10.5853/jos.2015.17.2.94.
2. Roh JH, Lee JH. Recent updates on subcortical ischemic vascular dementia. J Stroke. 2014;16:18-26. doi: 10.5853/jos.2014.16.1.18.
3. Poliak S, Peles E. The local differentiation of myelinated axons at nodes of Ranvier. Nat Rev Neurosci. 2003;4:968-980. doi: 10.1038/nrn1253.
4. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009;29:4351-4355. doi: 10.1523/JNEUROSCI.0035-09.2009.
5. Reimer MM, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A, et al. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion. J Neurosci. 2011;31:18185-18194. doi: 10.1523/JNEUROSCI.4936-11.2011.
6. Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4:316-329. doi: 10.1016/j.nurt.2007.05.011.
7. Choi BR, Lee SR, Han JS, Woo SK, Kim KM, Choi DH, et al. Synergistic memory impairment through the interaction of chronic cerebral hypoperfusion and amlyloid toxicity in a rat model. Stroke. 2011;42:2595-2604. doi: 10.1161/STROKEAHA.111.620179.
8. Kwon KJ, Lee EJ, Kim MK, Kim SY, Kim JN, Kim JO, et al. Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: implication of cilostazol for diabetes mellitus-induced dementia. Neurobiol Dis. 2015;73:12-23. doi: 10.1016/j.nbd.2014.08.034.
9. Watanabe T, Zhang N, Liu M, Tanaka R, Mizuno Y, Urabe T. Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion. Stroke. 2006;37:1539-1545. doi: 10.1161/01.STR.0000221783.08037.a9.
10. Miyamoto N, Tanaka R, Shimura H, Watanabe T, Mori H, Onodera M, et al. Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J Cereb Blood Flow Metab. 2010;30:299-310. doi: 10.1038/jcbfm.2009.210.
11. Kovács T. Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders. Ageing Res Rev. 2004;3:215-232. doi: 10.1016/j.arr.2003.10.003.
12. McQueen J, Reimer MM, Holland PR, Manso Y, McLaughlin M, Fowler JH, et al. Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. PLoS One. 2014;9:e87227. doi: 10.1371/journal.pone.0087227.
13. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, et al. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013;44:2573-2578. doi: 10.1161/STROKEAHA.113.001530.
14. Saab AS, Tzvetanova ID, Nave KA. The role of myelin and oligodendrocytes in axonal energy metabolism. Curr Opin Neurobiol. 2013;23:1065-1072. doi: 10.1016/j.conb.2013.09.008.
15. Reeves TM, Greer JE, Vanderveer AS, Phillips LL. Proteolysis of submembrane cytoskeletal proteins ankyrin-G and ?II-spectrin following diffuse brain injury: a role in white matter vulnerability at Nodes of Ranvier. Brain Pathol. 2010;20:1055-1068. doi: 10.1111/j.1750-3639.2010.00412.x.