Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA

Virology Journal

Volumn 12, Issue 1, 2015, Pages

  Su, Chenhe ^a   Zhang, Jie ^b   Zheng, Chunfu ^a,c  

^a SOOCHOW UNIVERSITY   (China)

^b WUHAN INSTITUTE OF VIROLOGY   (China)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

HSV 1; hZAP; Immune evasion; UL41

Indexed keywords

MESSENGER RNA; RIBONUCLEASE; UL41 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; ZINC FINGER ANTIVIRAL PROTEIN; ZINC FINGER PROTEIN; RNA BINDING PROTEIN; UL41 PROTEIN, HUMAN HERPESVIRUS 1; VIRAL PROTEIN; ZC3HAV1 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA DEGRADATION; VIRUS REPLICATION; WILD TYPE; ZAP GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; GENETICS; HERPES SIMPLEX VIRUS 1; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; RNA STABILITY;

ANIMALS; CELL LINE; HERPESVIRUS 1, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; RNA STABILITY; RNA-BINDING PROTEINS; VIRAL PROTEINS;

EID: 84949994196     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-015-0433-y     Document Type: Article

References (30)

1. Read GS, Karr BM, Knight K. Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide. J Virol. 1993;67:7149-60.
2. Smibert CA, Johnson DC, Smiley JR. Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41. J Gen Virol. 1992;73(Pt 2):467-70.
3. Saffran HA, Read GS, Smiley JR. Evidence for translational regulation by the herpes simplex virus virion host shutoff protein. J Virol. 2010;84:6041-9.
4. Dauber B, Pelletier J, Smiley JR. The herpes simplex virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner. J Virol. 2011;85:5363-73.
5. Oroskar AA, Read GS. Control of mRNA stability by the virion host shutoff function of herpes simplex virus. J Virol. 1989;63:1897-906.
6. Schek N, Bachenheimer SL. Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells. J Virol. 1985;55:601-10.
7. Read GS, Frenkel N. Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides. J Virol. 1983;46:498-512.
8. Gao G, Guo X, Goff SP. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. Science. 2002;297:1703-6.
9. Xuan Y, Liu L, Shen S, Deng H, Gao G. Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cells. J Virol. 2012;86:12431-4.
10. Kerns JA, Emerman M, Malik HS. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein. PLoS Genet. 2008;4, e21.
11. Wang X, Tu F, Zhu Y, Gao G. Zinc-finger antiviral protein inhibits XMRV infection. PLoS One. 2012;7, e39159.
12. Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A. 2011;108:15834-9.
13. Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, et al. ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. Nat Immunol. 2011;12:37-44.
14. Mao R, Nie H, Cai D, Zhang J, Liu H, Yan R, et al. Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein. PLoS Pathog. 2013;9, e1003494.
15. Taddeo B, Roizman B. The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A. J Virol. 2006;80:9341-5.
16. Bick MJ, Carroll JW, Gao G, Goff SP, Rice CM, MacDonald MR. Expression of the zinc-finger antiviral protein inhibits alphavirus replication. J Virol. 2003;77:11555-62.
17. Li Y, Wang S, Zhu H, Zheng C. Cloning of the herpes simplex virus type 1 genome as a novel luciferase-tagged infectious bacterial artificial chromosome. Arch Virol. 2011;156:2267-72.
18. Xing J, Wang S, Li Y, Guo H, Zhao L, Pan W, et al. Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells. Med Microbiol Immunol. 2011;200:61-8.
19. Muller S, Moller P, Bick MJ, Wurr S, Becker S, Gunther S, et al. Inhibition of filovirus replication by the zinc finger antiviral protein. J Virol. 2007;81:2391-400.
20. Zhu Y, Gao G. ZAP-mediated mRNA degradation. RNA Biol. 2008;5:65-7.
21. Smiley JR, Elgadi MM, Saffran HA. Herpes simplex virus vhs protein. Methods Enzymol. 2001;342:440-51.
22. Smibert CA, Smiley JR. Differential regulation of endogenous and transduced beta-globin genes during infection of erythroid cells with a herpes simplex virus type 1 recombinant. J Virol. 1990;64:3882-94.
23. Murphy JA, Duerst RJ, Smith TJ, Morrison LA. Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo. J Virol. 2003;77:9337-45.
24. Yao XD, Rosenthal KL. Herpes simplex virus type 2 virion host shutoff protein suppresses innate dsRNA antiviral pathways in human vaginal epithelial cells. J Gen Virol. 2011;92:1981-93.
25. Eisemann J, Muhl-Zurbes P, Steinkasserer A, Kummer M. Infection of mature dendritic cells with herpes simplex virus type 1 interferes with the interferon signaling pathway. Immunobiology. 2007;212:877-86.
26. MacDonald MR, Machlin ES, Albin OR, Levy DE. The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses. J Virol. 2007;81:13509-18.
27. Wang N, Dong Q, Li J, Jangra RK, Fan M, Brasier AR, et al. Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent. J Biol Chem. 2010;285:6080-90.
28. Xuan Y, Gong D, Qi J, Han C, Deng H, Gao G. ZAP inhibits murine gammaherpesvirus 68 ORF64 expression and is antagonized by RTA. J Virol. 2013;87:2735-43.
29. Xing J, Wang S, Lin F, Pan W, Hu CD, Zheng C. Comprehensive characterization of interaction complexes of herpes simplex virus type 1 ICP22, UL3, UL4, and UL20.5. J Virol. 2011;85:1881-6.
30. Zhu H, Zheng C, Xing J, Wang S, Li S, Lin R, et al. Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3. J Virol. 2011;85:11079-89.