A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs

Atherosclerosis

Volumn 245, Issue , 2016, Pages 62-70

  Wakil, Salma M ^a   Ram, Ramesh ^b   Muiya, Nzioka P ^a   Mehta, Munish ^b   Andres, Editha ^a   Mazhar, Nejat ^a   Baz, Batoul ^a   Hagos, Samya ^a   Alshahid, Maie ^a   Meyer, Brian F ^a   Morahan, Grant ^b   Dzimiri, Nduna ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

CDKN2A B; Coronary artery disease; CXCL12; Genome wide association; Haplotypes; Heritability; KCNE2; Myocardial infarction

Indexed keywords

ALPHA1 INTEGRIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GENOMIC DNA; INITIATION FACTOR 4A; POTASSIUM CHANNEL KCNE2; STROMAL CELL DERIVED FACTOR 1;

ANGIOCARDIOGRAPHY; ARTICLE; CHROMOSOME 9; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ECHOCARDIOGRAPHY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEART INFARCTION; HEART RHYTHM; HERITABILITY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SAUDI; SAUDI ARABIA; SINGLE NUCLEOTIDE POLYMORPHISM; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; METABOLISM; MIDDLE AGED; MYOCARDIAL INFARCTION; PROCEDURES; RISK FACTOR;

CORONARY ARTERY DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; RISK FACTORS; SAUDI ARABIA;

EID: 84949907947     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.11.019     Document Type: Article

References (53)

1. Lee H.Y., Oh B.H. Aging and arterial stiffness. Circ. J. 2010, 74:2257-2262.
2. Roger V.L., Go A.S., Lloyd-Jones D.M., Benjamin E.J., Berry J.D., et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012, 125:e2-e220.
3. Libby P., Theroux P. Pathophysiology of coronary artery disease. Circulation 2005, 111:3481-3488.
4. Consortium WTCC Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 2007, 447:661-678.
5. Tregouet D.A., Konig I.R., Erdmann J., Munteanu A., Braund P.S., et al. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat. Genet. 2009, 41:283-285.
6. Erdmann J., Grosshennig A., Braund P.S., Konig I.R., Hengstenberg C., et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat. Genet. 2009, 41:280-282.
7. Kathiresan S., Voight B.F., Purcell S., Musunuru K., Ardissino D., et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet. 2009, 41:334-341.
8. Schunkert H., Konig I.R., Kathiresan S., Reilly M.P., Assimes T.L., et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 2011, 43:333-338.
9. Al-Nozha M.M., Arafah M.R., Al-Mazrou Y.Y., Al-Maatouq M.A., Khan N.B., et al. Coronary artery disease in Saudi Arabia. Saudi Med. J. 2004, 25:1165-1171.
10. Thygesen K., Alpert J.S., White H.D. Universal definition of myocardial infarction. J. Am. Coll. Cardiol. 2007, 50:2173-2195.
11. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 81:559-575.
12. Yang J., Lee S.H., Goddard M.E., Visscher P.M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 2011, 88:76-82.
13. Lippert C., Listgarten J., Liu Y., Kadie C.M., Davidson R.I., et al. FaST linear mixed models for genome-wide association studies. Nat. Methods 2011, 8:833-835.
14. Widmer C., Lippert C., Weissbrod O., Fusi N., Kadie C., et al. Further improvements to linear mixed models for genome-wide association studies. Sci. Rep. 2014, 4:6874.
15. Willer C.J., Li Y., Abecasis G.R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 2010, 26:2190-2191.
16. Welter D., MacArthur J., Morales J., Burdett T., Hall P., et al. The NHGRI GWAS catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 2014, 42:D1001-D1006.
17. Hindorff L.A., MacArther J., Morales J., Junkins H.A., Hall P.N., et al. A Catalog of Published Genome-Wide Association Studies 2015, http://wwwgenomegov/gwastudies.
18. Namjou B., Keddache M., Marsolo K., Wagner M., Lingren T., et al. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Front. Genet. 2013, 4:268.
19. Sabater-Lleal M., Huang J., Chasman D., Naitza S., Dehghan A., et al. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation 2013, 128:1310-1324.
20. Stec J.J., Silbershatz H., Tofler G.H., Matheney T.H., Sutherland P., et al. Association of fibrinogen with cardiovascular risk factors and cardiovascular disease in the Framingham Offspring Population. Circulation 2000, 102:1634-1638.
21. Pozsgai G., Bodkin J.V., Graepel R., Bevan S., Andersson D.A., et al. Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo. Cardiovasc. Res. 2010, 87:760-768.
22. Nagamine T., Nomada S., Onouchi T., Kameshita I., Sueyoshi N. Nuclear translocation of doublecortin-like protein kinase and phosphorylation of a transcription factor JDP2. Biochem. Biophys. Res. Commun. 2014, 446:73-78.
23. Kerjan G., Koizumi H., Han E.B., Dube C.M., Djakovic S.N., et al. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:6766-6771.
24. Lionel A.C., Crosbie J., Barbosa N., Goodale T., Thiruvahindrapuram B., et al. Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci. Transl. Med. 2011, 3. 95ra75.
25. Abdullah K.G., Li L., Shen G.Q., Hu Y., Yang Y., et al. Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). Ann. Hum. Genet. 2008, 72:654-657.
26. Folsom A.R., Nambi V., Pankow J.S., Tang W., Farbakhsh K., et al. Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 2012, 224:435-439.
27. Xie F., Chu X., Wu H., Sun W., Shen M., et al. Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population. PLoS One 2011, 6:e20833.
28. Gioli-Pereira L., Santos P.C., Ferreira N.E., Hueb W.A., Krieger J.E., et al. Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21. BMC Cardiovasc. Disord. 2012, 12:61.
29. Meng W., Hughes A.E., Patterson C.C., Belton C., Kee F., et al. Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population. Dis. Markers 2008, 25:81-85.
30. Smith J.G., Melander O., Lovkvist H., Hedblad B., Engstrom G., et al. Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. Circ. Cardiovasc. Genet. 2009, 2:159-164.
31. Takeuchi F., Yokota M., Yamamoto K., Nakashima E., Katsuya T., et al. Genome-wide association study of coronary artery disease in the Japanese. Eur. J. Hum. Genet. 2012, 20:333-340.
32. Angelakopoulou A., Shah T., Sofat R., Shah S., Berry D.J., et al. Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: cardiovascular Biomarker Genetics Collaboration. Eur. Heart J. 2012, 33:393-407.
33. Bayoglu B., Cakmak H.A., Yuksel H., Can G., Karadag B., et al. Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome. Mol. Cell Biochem. 2013, 379(1-2):77-85.
34. Newton-Cheh C., Cook N.R., VanDenburgh M., Rimm E.B., Ridker P.M., et al. A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation 2009, 120:2062-2068.
35. Zhang L.W., Li J.P., Duan F.F., Liu Z.K., Zhan S.Y., et al. Interaction of type 2 diabetes mellitus with chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population. BMC Cardiovasc Disord. 2014, 14:170.
36. Wang Y., Wang L., Liu X., Zhang Y., Yu L., et al. Genetic variants associated with myocardial infarction and the risk factors in Chinese population. PLoS One 2014, 9:e86332.
37. Ghasemzadeh N., Hritani A.W., De Staercke C., Eapen D.J., Veledar E., et al. Plasma stromal cell-derived factor 1alpha/CXCL12 level predicts long-term adverse cardiovascular outcomes in patients with coronary artery disease. Atherosclerosis 2014, 238:113-118.
38. Mehta N.N., Matthews G.J., Krishnamoorthy P., Shah R., McLaughlin C., et al. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. Eur. Heart J. 2014, 35:2115-2122.
39. Kiechl S., Laxton R.C., Xiao Q., Hernesniemi J.A., Raitakari O.T., et al. Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2010, 30:2678-2683.
40. Derakhshan R., Arababadi M.K., Ahmadi Z., Karimabad M.N., Salehabadi V.A., et al. Increased circulating levels of SDF-1 (CXCL12) in type 2 diabetic patients are correlated to disease state but are unrelated to polymorphism of the SDF-1beta gene in the Iranian population. Inflammation 2012, 35:900-904.
41. Sabater-Lleal M., Malarstig A., Folkersen L., Soler Artigas M., Baldassarre D., et al. Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease. PLoS One 2014, 9:e104082.
42. Nielsen J.B., Bentzen B.H., Olesen M.S., David J.P., Olesen S.P., et al. Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation. Biomark. Med. 2014, 8:557-570.
43. Riuro H., Campuzano O., Berne P., Arbelo E., Iglesias A., et al. Genetic analysis, in silico prediction, and family segregation in long QT syndrome. Eur. J. Hum. Genet. 2014.
44. Wang D., Shah K.R., Um S.Y., Eng L.S., Zhou B., et al. Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths. Forensic Sci. Int. 2014, 237:90-99.
45. Jin X., Cheng H., Chen J., Zhu D. RNF13: an emerging RING finger ubiquitin ligase important in cell proliferation. FEBS J. 2011, 278:78-84.
46. van Dijk J.R., Yamazaki Y., Palmer R.H. Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization. Biochem. J. 2014, 459:27-36.
47. Zhang Q., Meng Y., Zhang L., Chen J., Zhu D. RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer. Cell Res. 2009, 19:348-357.
48. Tam C.W., Liu V.W., Leung W.Y., Yao K.M., Shiu S.Y. The autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53. Cancer Lett. 2008, 271:64-80.
49. Nguyen L.S., Kim H.G., Rosenfeld J.A., Shen Y., Gusella J.F., et al. Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders. Hum. Mol. Genet. 2013, 22:1816-1825.
50. Liu Y.Z., Wilson S.G., Wang L., Liu X.G., Guo Y.F., et al. Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. PLoS One 2008, 3:e3160.
51. Laurin N., Lee J., Ickowicz A., Pathare T., Malone M., et al. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B:600-605.
52. Yim D.H., Zhang Y.W., Eom S.Y., Moon S.I., Yun H.Y., et al. ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population. World J. Gastroenterol. 2013, 19:5870-5876.
53. Consortium CADCDG A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 2011, 43:339-344.