Immunogenicity and protective efficacy of an EV71 virus-like particle vaccine against lethal challenge in newborn mice

Human Vaccines and Immunotherapeutics

Volumn 11, Issue 10, 2015, Pages 2406-2413

  Sun, Shiyang ^a   Gao, Fan ^b   Mao, Qunying ^b   Shao, Jie ^a   Jiang, Liping ^a   Liu, Dawei ^c   Wang, Yiping ^b   Yao, Xin ^b   Wu, Xing ^b   Sun, Bo ^c   Zhao, Dandan ^a   Ma, Youlei ^c   Lu, Jingcai ^a   Kong, Wei ^a   Jiang, Chunlai ^a   Liang, Zhenglun ^b  

^a JILIN UNIVERSITY   (China)

^b NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL   (China)

^c Changchun BCHT Biotechnology Co Ltd   (China)

Author keywords

ED50 (50 effective dose); Enterovirus 71; Hand foot and mouth disease; HFMD; Immunogenicity; VLP vaccine

Indexed keywords

ENTEROVIRUS 71 VIRUS LIKE PARTICLE VACCINE; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE; RECOMBINANT VACCINE; VIRUS ANTIBODY;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; ENTEROVIRUS 71 INFECTION; ENTEROVIRUS INFECTION; HAND FOOT AND MOUTH DISEASE; IMMUNIZATION; IMMUNOGENICITY; LD50; LETHAL DOSE; MOUSE; NEWBORN; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); SURVIVAL; TRANSMISSION ELECTRON MICROSCOPY; VIRUS STRAIN; ANIMAL; BLOOD; DISEASE MODEL; ENTEROVIRUS A; ENTEROVIRUS INFECTIONS; FEMALE; IMMUNOLOGY; INSECT; INSTITUTE FOR CANCER RESEARCH MOUSE; PASSIVE IMMUNIZATION; SURVIVAL ANALYSIS;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; DISEASE MODELS, ANIMAL; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; FEMALE; IMMUNIZATION, PASSIVE; INSECTS; MICE, INBRED ICR; SURVIVAL ANALYSIS; VACCINES, SYNTHETIC; VACCINES, VIRUS-LIKE PARTICLE;

EID: 84949758475     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2015.1053675     Document Type: Article

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