Loci with genome-wide associations with schizophrenia in the Han Chinese population

British Journal of Psychiatry

Volumn 207, Issue 6, 2015, Pages 490-494

  Li, Zhiqiang ^a   Xiang, Yuqian ^a   Chen, Jianhua ^a   Li, Qiaoli ^a   Shen, Jiawei ^a   Liu, Yun ^a   Li, Wenjin ^a   Xing, Qinghe ^a   Wang, Qingzhong ^a   Wang, Lei ^a   Feng, Guoyin ^a   He, Lin ^a   Zhao, Xinzhi ^a   Shi, Yongyong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CALN1 GENE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FOLLOW UP; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; HAN CHINESE; HAPLOTYPE MAP; HUMAN; MAJOR CLINICAL STUDY; MALE; MIR137 GENE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHINA; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MIDDLE AGED; YOUNG ADULT;

ALPHA GLOBULIN; CALMODULIN; CALN1 PROTEIN, HUMAN; GLYCOPROTEIN; INTER-ALPHA-INHIBITOR; ITIH4 PROTEIN, HUMAN; LEUKOCYTE ELASTASE INHIBITOR; MICRORNA; MIRN137 MICRORNA, HUMAN; PLASMA PROTEIN;

ADULT; ALPHA-GLOBULINS; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PROTEINS; CALMODULIN; CASE-CONTROL STUDIES; CHINA; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GLYCOPROTEINS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84949742039     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.114.150490     Document Type: Article

References (36)

1. van Os J, Kapur S. Schizophrenia. Lancet 2009; 374: 635-45.
2. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009; 373: 234-9.
3. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60: 1187-92.
4. Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, et al. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry 2007; 12: 572-80.
5. Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, et al. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 2008; 4: e28.
6. Kirov G, Zaharieva I, Georgieva L, Moskvina V, Nikolov I, Cichon S, et al. A genome-wide association study in 574 schizophrenia trios using DNA pooling. Mol Psychiatry 2008; 14: 796-803.
7. Sullivan PF, Lin D, Tzeng JY, van den Oord E, Perkins D, Stroup TS, et al. Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry 2008; 13: 570-84.
8. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Sci Signalling 2008; 320: 539.
9. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, et al. Common variants conferring risk of schizophrenia. Nature 2009; 460: 744-7.
10. Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, et al. A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet 2009; 5: e1000373.
11. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008; 40: 1053-5.
12. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748-52.
13. Schizophrenia Psychiatric Genome-Wide Association Study C. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011; 43: 969-76.
14. Yue WH, Wang HF, Sun LD, Tang FL, Liu ZH, Zhang HX, et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet 2011; 43: 1228-31.
15. Shi Y, Li Z, Xu Q, Wang T, Li T, Shen J, et al. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet 2011; 43: 1224-7.
16. Bergen SE, O'Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S, et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry 2012; 17: 880-6.
17. Strange A, Riley BP, Spencer CCA, Morris DW, Pirinen M, O'Dushlaine CT, et al. Genome-wide association study implicates HLA-C∗ 01: 02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biol Psychiatry 2012; 72: 620-8.
18. Levinson DF, Shi J, Wang K, Oh S, Riley B, Pulver AE, et al. Genome-wide association study of multiplex schizophrenia pedigrees. Am J Psychiatry 2012; 169: 963-73.
19. Betcheva ET, Yosifova AG, Mushiroda T, Kubo M, Takahashi A, Karachanak SK, et al. Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatr Genet 2013; 23: 11-9.
20. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009; 460: 753-7.
21. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748-52.
22. Kim AH, Parker EK, Williamson V, McMichael GO, Fanous AH, Vladimirov VI. Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137. Schizophria Res 2012; 141: 60-4.
23. Kwon E, Wang W, Tsai LH. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Mol Psychiatry 2013; 18: 11-2.
24. Hamshere ML, Walters JT, Smith R, Richards AL, Green E, Grozeva D, et al. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry 2013: 18: 708-12.
25. Li T, Li Z, Chen P, Zhao Q, Wang T, Huang K, et al. Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry 2010; 68: 671-3.
26. Gelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH, et al. Genome-wide association study of alcohol dependence: significant findings in African-and European-Americans including novel risk loci. Mol Psychiatry 2014; 19: 41-9.
27. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). APA, 1994.
28. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263.
29. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-75.
30. Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, et al. Population genomics of human gene expression. Nat Genet 2007; 39: 1217-24.
31. Kashyap RS, Nayak AR, Deshpande PS, Kabra D, Purohit HJ, Taori GM, et al. Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke. Clinica Chimica Acta 2009; 402: 160-3.
32. Tsai KY, Lee CC, Chou YM, Su CY, Chou FHC. The incidence and relative risk of stroke in patients with schizophrenia: a five-year follow-up study. Schizophr Res 2012; 138: 41-7.
33. Lin HC, Hsiao FH, Pfeiffer S, Hwang YT, Lee HC. An increased risk of stroke among young schizophrenia patients. Schizophr Res 2008; 101: 234-41.
34. Wu YQ, Lin X, Liu CM, Jamrich M, Shaffer LG. Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily. Mol Genet Metab 2001; 72: 343-50.
35. Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kahler AK, Akterin S, et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 2013; 45: 1150-9.
36. Slavotinek AM, Rosenfeld JA, Chao R, Niyazov D, Eswara M, Bader PI, et al. A de novo deletion of CALN1 in a male with a bilateral diaphragmatic defect does not definitely cause this malformation. Am J Med Genet A 2011; 155: 1196-201.