Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation

Journal of Cardiology

Volumn 68, Issue 5, 2016, Pages 406-411

  Kusayama, Takashi ^a   Furusho, Hiroshi ^a   Kashiwagi, Haruka ^a   Kato, Takeshi ^a   Murai, Hisayoshi ^a   Usui, Soichiro ^a   Kaneko, Shuichi ^a   Takamura, Masayuki ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

Computed tomography; Epicardial adipose tissue; Inflammation; Left atrium; Paroxysmal atrial fibrillation

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IOVERSOL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ABDOMINAL FAT; ADULT; ARTICLE; BODY MASS; CARDIAC IMAGING; CATHETER ABLATION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; EPICARDIAL FAT; FEMALE; GROUPS BY AGE; HEART LEFT ATRIUM; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; MIDDLE AGED; PAROXYSMAL ATRIAL FIBRILLATION; RETROSPECTIVE STUDY; RISK FACTOR; SEX RATIO; SOFT TISSUE INFLAMMATION; SUBCUTANEOUS FAT; THORAX; TRIACYLGLYCEROL BLOOD LEVEL; ADIPOSE TISSUE; ATRIAL FIBRILLATION; CASE CONTROL STUDY; DIAGNOSTIC IMAGING; HEART ATRIUM; INFLAMMATION; PERICARDIUM; X-RAY COMPUTED TOMOGRAPHY;

ADIPOSE TISSUE; ATRIAL FIBRILLATION; CASE-CONTROL STUDIES; CATHETER ABLATION; FEMALE; HEART ATRIA; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PERICARDIUM; RETROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84949678677     PISSN: 09145087     EISSN: 18764738     Source Type: Journal    
DOI: 10.1016/j.jjcc.2015.11.005     Document Type: Article

References (28)

1. [1] Benjamin, E.J., Wolf, P.A., D'Agostino, R.B., Silbershatz, H., Kannel, W.B., Levy, D., Impact of atrial fibrillation on the risk of death: The Framingham Heart Study. Circulation 98 (1998), 946–952.
2. [2] Benjamin, E.J., Levy, D., Vaziri, S.M., D'Agostino, R.B., Belanger, A.J., Wolf, P.A., Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA 271 (1994), 840–844.
3. [3] Rosengren, A., Hauptman, P.J., Lappas, G., Olsson, L., Wilhelmsen, L., Swedberg, K., Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. Eur Heart J 30 (2009), 1113–1120.
4. [4] Rosito, G.A., Massaro, J.M., Hoffmann, U., Ruberg, F.L., Mahabadi, A.A., Vasan, R.S., O'Donnell, C.J., Fox, C.S., Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study. Circulation 117 (2008), 605–613.
5. [5] Goudis, C.A., Korantzopoulos, P., Ntalas, I.V., Kallergis, E.M., Ketikoglou, D.G., Obesity and atrial fibrillation: a comprehensive review of the pathophysiological mechanisms and links. J Cardiol 66 (2015), 361–369.
6. [6] Al Chekakie, M.O., Welles, C.C., Metoyer, R., Ibrahim, A., Shapira, A., Cytron, J., Santucci, P., Wilber, D.J., Akar, J.G., Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol 56 (2010), 784–788.
7. [7] Tsao, H.M., Hu, W.C., Wu, M.H., Tai, C.T., Lin, Y.J., Chang, S.L., Lo, L.W., Hu, Y.F., Tuan, T.C., Wu, T.J., Sheu, M.H., Chang, C.Y., Chen, S.A., Quantitative analysis of quantity and distribution of epicardial adipose tissue surrounding the left atrium in patients with atrial fibrillation and effect of recurrence after ablation. Am J Cardiol 107 (2011), 1498–1503.
8. [8] Batal, O., Schoenhagen, P., Shao, M., Ayyad, A.E., Van wagoner, D.R., Hallburton, S.S., Tchou, P.J., Chung, M.K., Left atrial epicardial adiposity and atrial fibrillation. Circ Arrhythm Electrophysiol 3 (2010), 230–236.
9. [9] Opolski, M.P., Staruch, A.D., Kusmierczyk, M., Witkowski, A., Kwiecinska, S., Kosek, M., Jastrzebski, J., Pregowski, J., Kruk, M., Rozanski, J., Demkow, M., Ruzyllo, W., Kepka, C., Computed tomography angiography for prediction of atrial fibrillation after coronary artery bypass grafting: proof of concept. J Cardiol 65 (2015), 285–292.
10. [10] Mazurek, T., Zhang, L., Zalewski, A., Mannion, J.D., Diehl, J.T., Arafat, H., Sarov-Blat, L., O'Brien, S., Keiper, E.A., Johnson, A.G., Martin, J., Goldstein, B.J., Shi, Y., Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108 (2003), 2460–2466.
11. [11] Konishi, M., Sugiyama, S., Sugamura, K., Nozaki, T., Ohba, K., Matsubara, J., Matsuzawa, Y., Sumida, H., Nagayoshi, Y., Nakaura, T., Awai, K., Yamashita, Y., Jinnouchi, H., Matsui, K., Kimura, K., et al. Association of pericardial fat accumulation rather than abdominal obesity with coronary atherosclerotic plaque formation in patients with suspected coronary artery disease. Atherosclerosis 209 (2010), 573–578.
12. [12] Mahabadi, A.A., Massaro, J.M., Rosito, G.A., Levy, D., Murabito, J.M., Wolf, P.A., O'Donnell, C.J., Fox, C.S., Hoffmann, U., Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J 30 (2009), 850–856.
13. [13] Jeong, J.W., Jeong, M.H., Yun, K.H., Oh, S.K., Park, E.M., Kim, Y.K., Rhee, S.J., Lee, E.M., Lee, J., Yoo, N.J., Kim, N.H., Park, J.C., Echocardiographic epicardial fat thickness and coronary artery disease. Circ J 71 (2007), 536–539.
14. [14] Iwayama, T., Nitobe, J., Watanabe, T., Ishino, M., Tamura, H., Nishiyama, S., Takahashi, H., Arimoto, T., Shishido, T., Miyashita, T., Miyamoto, T., Toyama, S., Sadahiro, M., Kubota, I., Role of epicardial adipose tissue in coronary artery disease in non-obese patients. J Cardiol 63 (2014), 344–349.
15. [15] Konishi, M., Sugiyama, S., Sato, Y., Oshima, S., Sugamura, K., Nozaki, T., Ohba, K., Matsubara, J., Sumida, H., Nagayoshi, Y., Sakamoto, K., Utsunomiya, D., Awai, K., Jinnouchi, H., Matsuzawa, Y., et al. Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis 213 (2010), 649–655.
16. [16] Nakagawa, H., Scherlag, B.J., Patterson, E., Ikeda, A., Lockwood, D., Jackman, W.M., Pathophysiologic basis of autonomic ganglionated plexus ablation in patients with atrial fibrillation. Heart Rhythm 6 (2009), S26–S34.
17. [17] Kawashima, T., The autonomic nervous system of the human heart with special reference to its origin, course, and peripheral distribution. Anat Embryol (Berl) 209 (2005), 425–438.
18. [18] Friedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972), 499–502.
19. [19] Iacobellis, G., Corradi, D., Sharma, A.M., Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2 (2005), 536–543.
20. [20] Zhang, M., Kono, M., Solitary pulmonary nodules: evaluation of blood flow patterns with dynamic CT. Radiology 205 (1997), 471–478.
21. [21] Sawaya, S.E., Rajawat, Y.S., Rami, T.G., Szalai, G., Price, R.L., Sivasubramanian, N., Mann, D.L., Khoury, D.S., Downregulation of connexin40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor. Am J Physiol Heart Circ Physiol 292 (2007), H1561–H1567.
22. [22] Marcus, G.M., Whooley, M.A., Glidden, D.V., Pawlikowska, L., Zaroff, J.G., Olgin, J.E., Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study. Am Heart J 155 (2008), 303–309.
23. [23] Tselentakis, E.V., Woodford, E., Chandy, J., Gaudette, G.R., Saltman, A.E., Inflammation effects on the electrical properties of atrial tissue and inducibility of postoperative atrial fibrillation. J Surg Res 135 (2006), 68–75.
24. [24] Chilukoti, R.K., Giese, A., Malenke, W., Homuth, G., Bukowska, A., Felix, S.B., Kanaan, J., Wollert, H.G., Evert, K., Verheule, S., Jais, P., Hatem, S.N., Lendeckel, U., Wolke, C., Atrial fibrillation and rapid acute pacing regulate adipocyte/adipositas-related gene expression in the atria. Int J Cardiol 187 (2015), 604–613.
25. [25] Mazurek, T., Kiliszek, M., Kobylecka, M., Skubisz-Gluchowska, J., Kochman, J., Filipiak, K., Królicki, L., Opolski, G., Relation of proinflammatory activity of epicardial adipose tissue to the occurrence of atrial fibrillation. Am J Cardiol 113 (2014), 1505–1508.
26. [26] Aviles, R.J., Martin, D.O., Apperson-Hansen, C., Houghtaling, P.L., Rautaharju, P., Kronmal, R.A., Tracy, R.P., Van Wagoner, D.R., Psaty, B.M., Lauer, M.S., Chung, M.K., Inflammation as a risk factor for atrial fibrillation. Circulation 108 (2003), 3006–3010.
27. [27] Palmas, W., Ma, S., Psaty, B., Goff, D.C. Jr., Darwin, C., Barr, R.G., Antihypertensive medications and C-reactive protein in the multi-ethnic study of atherosclerosis. Am J Hypertens 20 (2007), 233–241.
28. [28] Kizer, J.R., Bella, J.N., Palmieri, V., Liu, J.E., Best, L.G., Lee, E.T., Roman, M.J., Devereux, R.B., Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: The Strong Heart Study (SHS). Am Heart J 151 (2006), 412–418.