The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: Results of an aborted randomised placebo-controlled trial

Trials

Volumn 16, Issue 1, 2015, Pages

  Zhou, Shao J ^a,b   Skeaff, Sheila A ^c   Ryan, Philip ^b   Doyle, Lex W ^d,e   Anderson, Peter J ^d,e   Kornman, Louise ^d   Mcphee, Andrew J ^f   Yelland, Lisa N ^a,b   Makrides, Maria ^a,g,h  

^a CHILD HEALTH RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^f Women's and Children's Health Network   (Australia)

^g UNIVERSITY OF ADELAIDE   (Australia)

^h SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Child development; Iodine; Pregnancy; RCT; Supplementation

Indexed keywords

IODINE; THYROTROPIN; POTASSIUM IODIDE;

ADAPTIVE BEHAVIOR; ARTICLE; BIRTH WEIGHT; CHILD DEVELOPMENT; COGNITION; DEVELOPMENTAL DISORDER; DIET SUPPLEMENTATION; DISEASE SEVERITY; EMOTION; FEMALE; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HEART PALPITATION; HUMAN; LANGUAGE ABILITY; MOTOR PERFORMANCE; NERVE CELL DIFFERENTIATION; PREGNANCY OUTCOME; PREMATURE LABOR; PUERPERAL DEPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORING SYSTEM; SOCIAL BEHAVIOR; SPONTANEOUS ABORTION; STILLBIRTH; THYROID FUNCTION; ADULT; ADVERSE EFFECTS; AGE; AUSTRALIA; CLINICAL TRIAL; CONTROLLED STUDY; DIETARY SUPPLEMENT; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EARLY TERMINATION OF CLINICAL TRIAL; GROWTH, DEVELOPMENT AND AGING; INFANT; LANGUAGE DEVELOPMENT; MALE; MATERNAL WELFARE; METHODOLOGY; MOTOR ACTIVITY; MULTICENTER STUDY; NERVOUS SYSTEM; NEUROPSYCHOLOGICAL TEST; NEW ZEALAND; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL CARE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; THYROID FUNCTION TEST; THYROID GLAND; TIME FACTOR; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AGE FACTORS; AUSTRALIA; CHILD DEVELOPMENT; CHILD LANGUAGE; COGNITION; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EARLY TERMINATION OF CLINICAL TRIALS; FEMALE; HUMANS; INFANT; MALE; MATERNAL HEALTH; MOTOR ACTIVITY; NERVOUS SYSTEM; NEUROPSYCHOLOGICAL TESTS; NEW ZEALAND; POTASSIUM IODIDE; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL CARE; RESEARCH DESIGN; THYROID FUNCTION TESTS; THYROID GLAND; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84949669723     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/s13063-015-1080-8     Document Type: Article

References (28)

1. Hetzel BS, Potter BJ, Dulberg EM. The iodine deficiency disorders: nature, pathogenesis and epidemiology. World Rev Nutr Diet. 1990;62:59-119.
2. Delange F. Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition. Public Health Nutr. 2007;10:1571-80. Discussion 1581-3.
3. Zhou SJ, Anderson AJ, Gibson RA, Makrides M. Effect of iodine supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials. Am J Clin Nutr. 2013;98:1241-54.
4. Velasco I, Carreira M, Santiago P, Muela JA, Garcia-Fuentes E, Sanchez-Munoz B, et al. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J Clin Endocrinol Metab. 2009;94:3234-41.
5. Rebagliato M, Murcia M, Alvarez-Pedrerol M, Espada M, Fernandez-Somoano A, Lertxundi N, et al. Iodine Supplementation During Pregnancy and Infant Neuropsychological Development: INMA Mother and Child Cohort Study. Am J Epidemiol. 2013;177:944-53.
6. Lazarus J, Brown RS, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B. 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J. 2014;3:76-94.
7. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081-125.
8. World Health Organisation, UNICEF. Reaching Optimal Iodine Nutrition in Pregnant and Lactating Women and Young Children. 2007 [cited 2015 06/02/2015]; Available from: http://www.who.int/nutrition/publications/micronutrients/WHOStatement__IDD_pregnancy.pdf.
9. National Health & Medical Research Council. Iodine supplementation for pregnant and breastfeeding women. Canberra, Australia: National Health & Medical Research Council; 2010.
10. Australian Population Health Development Principal Committee. The prevalence and severity of iodine deficiency in Australia. Report commissioned by the Australian Health Ministers Advisory Committee. Canberra, Australia; 2007. Available from: http://www.foodstandards.gov.au/code/proposals/documents/The%20prevalence%20and%20severity%20of%20iodine%20deficiency%20in%20Australia%2013%20Dec%202007.pdf.
11. Bayley N. Bayley scales of infant and toddler development. 3rd ed. San Antonio, TX: Pearson Education, Inc.; 2006.
12. Roberts G, Anderson PJ, Doyle LW, Victorian Infant Collaborative Study Group. The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997. Arch Dis Child. 2010;95:786-90.
13. Ohashi T, Yamaki M, Pandav CS, Karmarkar MG, Irie M. Simple microplate method for determination of urinary iodine. Clin Chem. 2000;46:529-36.
14. Huynh D, Zhou SJ, Gibson R, Palmer L, Muhlhausler B. Validation of an optimized method for the determination of iodine in human breast milk by inductively coupled plasma mass spectrometry (ICPMS) after tetramethylammonium hydroxide extraction. J Trace Elem Med Biol. 2015;29:75-82.
15. Roberts CL, Lancaster PA. Australian national birthweight percentiles by gestational age. Med J Aust. 1999;170:114-8.
16. Ware JE, Kosinski M, Gandek B. SF-36 health survey: manual and interpretation guide. Lincoln, RI: Quality Metric; 2005.
17. Henry JD, Crawford JR. The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br J Clin Psychol. 2005;44:227-39.
18. Carpenter DO. Effects of metals on the nervous system of humans and animals. Int J Occup Med Environ Health. 2001;14:209-18.
19. Walter T, Lozoff B. Prevention of iron-deficiency anemia: comparison of high- and low-iron formulas in term healthy infants after six months of life. J Pediatr. 1998;132:635.
20. Australian Bureau of Statistics. 4364.0.55.006 - Australian Health Survey: Biomedical Results for Nutrients 2011-12. Sydney, Australia: Australian Bureau of Statistics; 2014. Available from: http://www.abs.gov.au/ausstats/abs@.nsf/Lookup/4364.0.55.006Chapter1202011-12.
21. Kevany J, Fierro-Benitez R, Pretell EA, Stanbury JB. Prophylaxis and treatment of endemic goiter with iodized oil in rural Ecuador and Peru. Am J Clin Nutr. 1969;22:1597-607.
22. Pharoah PO, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet. 1971;1:308-10.
23. Berbel P, Mestre JL, Santamaria A, Palazon I, Franco A, Graells M, et al. Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid. 2009;19:511-9.
24. Bath SC, Steer CD, Golding J, Emmett P, Rayman MP. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet. 2013;382:331-7.
25. Hynes KL, Otahal P, Hay I, Burgess JR. Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort. J Clin Endocrinol Metab. 2013;98:1954-62.
26. Ghassabian A, Steenweg-de Graaff J, Peeters RP, Ross HA, Jaddoe VW, Hofman A, et al. Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area. BMJ Open. 2014;4:e005520.
27. Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010;304:1675-83.
28. Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009;89:668S-72.