Intravenous combined with aerosolised polymyxin versus intravenous polymyxin alone in the treatment of pneumonia caused by multidrug-resistant pathogens: A systematic review and meta-analysis

International Journal of Antimicrobial Agents

Volumn 46, Issue 6, 2015, Pages 603-609

  Liu, Dong ^a   Zhang, Jing ^a   Liu, Hai Xia ^a   Zhu, Ying Gang ^a   Qu, Jie Ming ^a,b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Adjuvant therapy; Aerosolised colistin; Meta analysis; Multidrug resistant Gram negative bacteria; Nosocomial pneumonia

Indexed keywords

COLISTIN; ANTIINFECTIVE AGENT; NOSE SPRAY;

AEROSOL; BACTERIAL CLEARANCE; CASE CONTROL STUDY; DRUG EFFICACY; DRUG SAFETY; GRAM NEGATIVE BACTERIUM; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; META ANALYSIS; MORTALITY; MULTIDRUG RESISTANCE; NEPHROTOXICITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; SYSTEMATIC REVIEW; CRITICAL ILLNESS; DRUG EFFECTS; GRAM-NEGATIVE BACTERIAL INFECTIONS; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MICROBIOLOGY; PNEUMONIA, VENTILATOR-ASSOCIATED; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADMINISTRATION, INTRAVENOUS; ANTI-BACTERIAL AGENTS; COLISTIN; CRITICAL ILLNESS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; NASAL SPRAYS; PNEUMONIA, VENTILATOR-ASSOCIATED; TREATMENT OUTCOME;

EID: 84949623735     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.09.011     Document Type: Review

References (30)

1. S. Golia, K.T. Sangeetha, and C.L. Vasudha Microbial profile of early and late onset ventilator associated pneumonia in the intensive care unit of a tertiary care hospital in Bangalore, India J Clin Diagn Res 7 2013 2462 2466
2. American Thoracic Society: Infectious Diseases Society of America Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia Am J Respir Crit Care Med 171 2005 388 416
3. M.E. Falagas, S.K. Kasiakou, S. Tsiodras, and A. Michalopoulos The use of intravenous and aerosolized polymyxins for the treatment of infections in critically ill patients: a review of the recent literature Clin Med Res 4 2006 138 146
4. P.E. Grgurich, J. Hudcoa, Y. Lei, A. Sarwar, and D.E. Craven Management and prevention of ventilator-associated pneumonia caused by multidrug-resistant pathogens Expert Rev Respir Med 6 2012 533 555
5. J. Li, R.L. Nation, J.D. Turnidge, R.W. Milne, K. Coulthard, C.R. Rayner, and et al. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections Lancet Infect Dis 6 2006 589 601
6. C.R. Catchpole, J.M. Andrews, N. Brenwald, and R. Wise A reassessment of the in-vitro activity of colistin sulphomethate sodium J Antimicrob Chemother 39 1997 255 260
7. I. Sermet-Gaudelus, Y. Le Cocguic, A. Ferroni, M. Clairicia, J. Barthe, J.P. Delaunay, and et al. Nebulized antibiotics in cystic fibrosis Paediatr Drugs 4 2002 455 467
8. M.E. Falagas, and P.I. Rafailidis Re-emergence of colistin in today's world of multidrug-resistant organisms: personal perspectives Expert Opin Investig Drugs 17 2008 973 981
9. G. Taccetti, S. Campana, A.S. Neri, V. Boni, and F. Festini Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis J Chemother 20 2008 166 169
10. A. Michalopoulos, and E. Papadakis Inhaled anti-infective agents: emphasis on colistin Infection 38 2010 81 88
11. D.F. Florescu, F. Qiu, M.A. McCartan, C. Mindru, P.D. Fey, and A.C. Kalil What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regression Clin Infect Dis 54 2012 670 680
12. A. Michalopoulos, D. Fotakis, S. Virtzili, C. Vletsas, S. Raftopoulou, Z. Mastora, and et al. Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: a prospective study Respir Med 102 2008 407 412
13. I.P. Korbila, A. Michalopoulos, P.I. Rafailidis, D. Nikita, G. Samonis, and M.E. Falagas Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia: a comparative cohort study Clin Microbiol Infect 16 2010 1230 1236
14. M. Tumbarello, G. De Pascale, E.M. Trecarichi, S. De Martino, G. Bello, R. Maviglia, and et al. Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible Gram-negative bacteria Chest 144 2013 1768 1775
15. D.P. Kofteridis, C. Alexopoulou, A. Valachis, S. Maraki, D. Dimopoulou, D. Georgopoulos, and et al. Aerosolized plus intravenous colistin versus intravenous colistin alone for the treatment of ventilator-associated pneumonia: a matched case-control study Clin Infect Dis 51 2010 1238 1244
16. G. Kalin, E. Alp, R. Coskun, H. Demiraslan, K. Gundogan, and M. Doganay Use of high-dose IV and aerosolized colistin for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia: do we really need this treatment? J Infect Chemother 18 2012 872 877
17. R. Naesens, E. Vlieghe, W. Verbrugghe, P. Jorens, and M. Ieven A retrospective observational study on the efficacy of colistin by inhalation as compared to parenteral administration for the treatment of nosocomial pneumonia associated with multidrug-resistant Pseudomonas aeruginosa BMC Infect Dis 11 2011 317
18. M. Amin, A. Rashad, A. Fouad, and A. Abdel Azeem Re-emerging of colistin for treatment of nosocomial pneumonia due to Gram negative multi-drug resistant pathogens in critically ill patients Egypt J Chest Dis Tuberculosis 62 2013 447 451
19. T.Z. Bogovic, A. Budimir, Z. Bosnjak, P. Hrabac, R. Baronica, B. Tomasevic, and et al. Inhalation plus intravenous colistin versus intravenous colistin alone for treatment of ventilator associated pneumonia Signa Vitae 9 2014 29 33
20. N.M. Doshi, C.H. Cook, K.L. Mount, S.P. Stawicki, E.N. Frazee, H.A. Personett, and et al. Adjunctive aerosolized colistin for multi-drug resistant Gram-negative pneumonia in the critically ill: a retrospective study BMC Anesthesiol 13 2013 45
21. M.J. Pérez-Pedrero, M. Sánchez-Casado, and S. Rodríguez-Villar Nebulized colistin treatment of multi-resistant Acinetobacter baumannii pulmonary infection in critical ill patients Med Intensiva 35 2011 226 231 [in Spanish]
22. G.A. Wells, B. Shea, D. O'Connell, J. Peterson, V. Welch, M. Losos, and et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses 2011 Ottawa Hospital Research Institute Ottawa, ON, Canada http://www.ohri.ca/programs/clinical-epidemiology/oxford.asp [accessed 9.10.15]
23. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 2002 1539 1558
24. P. Rattanaumpawan, J. Lorsutthitham, P. Ungprasert, N. Angkasekwinai, and V. Thamlikitkul Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria J Antimicrob Chemother 65 2010 2645 2649
25. S.W.S. Yapa, J. Li, K. Patel, J.W. Wilson, M.J. Dooley, J. George, and et al. Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration Antimicrob Agents Chemother 58 2014 2570 2579
26. A.L. Kwa, C. Loh, J.G. Low, A. Kurup, and V.H. Tam Nebulized colistin in the treatment of pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa Clin Infect Dis 41 2005 754
27. G.C. Wood Aerosolized antibiotics for treating hospital-acquired and ventilator-associated pneumonia Expert Rev Anti Infect Ther 9 2011 993 1000
28. C.E. Luyt, N. Bréchot, A. Combes, J.L. Trouillet, and J. Chastre Delivering antibiotics to the lungs of patients with ventilator-associated pneumonia: an update Expert Rev Anti Infect Ther 11 2013 511 521
29. A.S. Levin, A.A. Barone, J. Penço, M.V. Santos, I.S. Marinho, E.A. Arruda, and et al. Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii Expert Rev Anti Infect Ther 28 1999 1008 1011
30. J. Garnacho-Montero, C. Ortiz-Leyba, F.J. Jiménez-Jiménez, A.E. Barrero-Almodóvar, J.L. García-Garmendia, M. Bernbeu-Wittell, and et al. Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP Clin Infect Dis 36 2003 1111 1118