Combined use of the Ilizarov method, concentrated bone marrow aspirate (cBMA), and platelet-rich plasma (PRP) to expedite healing of bimalleolar fractures

Strategies in Trauma and Limb Reconstruction

Volumn 10, Issue 3, 2015, Pages 161-166

  Rodriguez Collazo, Edgardo R ^a   Urso, Maria L ^b  

^a SAINT JOSEPH HOSPITAL   (United States)

^b Arteriocyte Medical Systems   (United States)

Author keywords

Comorbidities; Fibula; Fracture; Mesenchymal stem cell; Nonunion; Tibia

Indexed keywords

EID: 84949321164     PISSN: 18288936     EISSN: 18288928     Source Type: Journal    
DOI: 10.1007/s11751-015-0239-x     Document Type: Article

References (20)

1. Krappinger D, Irenberger A, Zegg M, Huber B (2013) Treatment of large posttraumatic tibial bone defects using the Ilizarov method: a subjective outcome assessment. Arch Orthop Trauma Surg 133(6):789–795. doi:10.1007/s00402-013-1712-y
2. Blum AL, BongioVanni JC, Morgan SJ, Flierl MA, dos Reis FB (2010) Complications associated with distraction osteogenesis for infected nonunion of the femoral shaft in the presence of a bone defect: a retrospective series. J Bone Joint Surg Br 92(4):565–570. doi:10.1302/0301-620X.92B4.23475
3. Sella EJ (2008) Prevention and management of complications of the Ilizarov treatment method. Foot Ankle Spec 1(2):105–107. doi:10.1177/1938640008315349
4. Ramos T, Karlsson J, Eriksson BI, Nistor L (2013) Treatment of distal tibial fractures with the Ilizarov external fixator—a prospective observational study in 39 consecutive patients. BMC Musculoskelet Disord 14:30. doi:10.1186/1471-2474-14-30
5. Brinker MR, O’Connor DP (2007) Outcomes of tibial nonunion in older adults following treatment using the Ilizarov method. J Orthop Trauma 21(9):634–642. doi:10.1097/BOT.0b013e318156c2a2
6. Pieske O, Wittmann A, Zaspel J, Loffler T, Rubenbauer B, Trentzsch H, Piltz S (2009) Autologous bone graft versus demineralized bone matrix in internal fixation of ununited long bones. J Trauma Manag Outcomes 3:11. doi:10.1186/1752-2897-3-11
7. Gruskin E, Doll BA, Futrell FW, Schmitz JP, Hollinger JO (2012) Demineralized bone matrix in bone repair: history and use. Adv Drug Deliv Rev 64(12):1063–1077. doi:10.1016/j.addr.2012.06.008
8. Barry FP (2003) Mesenchymal stem cell therapy in joint disease. Novartis Found Symp 249:86–96 (discussion 96–102, 170–104, 239–141)
9. Gobbi A, Bathan L (2009) Biological approaches for cartilage repair. J Knee Surg 22(1):36–44
10. Hauser RA, Orlofsky A (2013) Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series. Clin Med Insights Arthritis Musculoskelet Disord 6:65–72. doi:10.4137/CMAMD.S10951
11. Turajane T, Chaweewannakorn U, Larbpaiboonpong V, Aojanepong J, Thitiset T, Honsawek S, Fongsarun J, Papadopoulos KI (2013) Combination of intra-articular autologous activated peripheral blood stem cells with growth factor addition/preservation and hyaluronic acid in conjunction with arthroscopic microdrilling mesenchymal cell stimulation Improves quality of life and regenerates articular cartilage in early osteoarthritic knee disease. J Med Assoc Thail Chotmaihet Thangphaet 96(5):580–588
12. Mehta S, Watson JT (2008) Platelet rich concentrate: basic science and current clinical applications. J Orthop Trauma 22(6):432–438. doi:10.1097/BOT.0b013e31817e793f
13. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, Moroni M, Carabelli A (2004) Platelet gel for healing cutaneous chronic wounds. Transfus Apheresis Sci 30(2):145–151. doi:10.1016/j.transci.2004.01.004
14. Lubkowska A, Dolegowska B, Banfi G (2012) Growth factor content in PRP and their applicability in medicine. J Biol Regul Homeost Agents 26(2 Suppl. 1):3S–22S
15. Yang HS, Shin J, Bhang SH, Shin JY, Park J, Im GI, Kim CS, Kim BS (2011) Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma. Exp Mol Med 43(11):622–629. doi:10.3858/emm.2011.43.11.070
16. Guo Y, Qiu J, Zhang C (2008) Follow-up study on platelet-rich plasma in repairing chronic wound nonunion of lower limbs in 47 cases. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chin J Repar Reconstr Surg 22(11):1301–1305
17. Anitua E, Alonso R, Girbau C, Aguirre JJ, Muruzabal F, Orive G (2012) Antibacterial effect of plasma rich in growth factors (PRGF(R)-Endoret(R)) against Staphylococcus aureus and Staphylococcus epidermidis strains. Clin Exp Dermatol 37(6):652–657. doi:10.1111/j.1365-2230.2011.04303.x
18. Phemister DB (1947) Treatment of ununited fractures by onlay bone grafts without screw or tie fixation and without breaking down of the fibrous union. J Bone Joint SurgAm 29(4):946–960
19. Kasemkijwattana C, Hongeng S, Kesprayura S, Rungsinaporn V, Chaipinyo K, Chansiri K (2011) Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two cases report. J Med Assoc Thail Chotmaihet Thangphaet 94(3):395–400
20. Khalafi RS, Bradford DW, Wilson MG (2008) Topical application of autologous blood products during surgical closure following a coronary artery bypass graft. Eur J Cardio Thorac Surg 34(2):360–364. doi:10.1016/j.ejcts.2008.04.026