Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: A case series

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

Volumn 6, Issue , 2013, Pages

  Hauser, Ross A ^a   Orlofsky, Amos ^b  

^a Caring Medical and Rehabilitation Services   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Bone marrow aspirate; Case series; Chronic pain; Osteoarthritis; Prolotherapy

Indexed keywords

CORTISONE;

ADULT; AGED; ANKLE ARTHRITIS; ANKLE OSTEOARTHRITIS; ANKLE PAIN; ARTHRALGIA; ARTICLE; BONE MARROW; CLINICAL ARTICLE; EXERCISE TOLERANCE; FEMALE; FUNCTIONAL STATUS; HIP OSTEOARTHRITIS; HIP PAIN; HUMAN; ILIAC BONE; JOINT STIFFNESS; KNEE OSTEOARTHRITIS; KNEE PAIN; MALE; OSTEOARTHRITIS; QUALITY OF LIFE; RANGE OF MOTION; TIBIA; WHOLE BONE MARROW INJECTION;

EID: 84884146493     PISSN: 11795441     EISSN: 11795441     Source Type: Journal    
DOI: 10.4137/CMAMD.S10951     Document Type: Article

References (27)

1. Kelsey JL, Hochberg MC. Epidemiology of chronic musculoskeletal disorders. Ann Rev Public Health. 1988;9:379-401.
2. Yelin EH, Trupin LS, Sebesta DS. Transitions in employment, morbidity, and disability among persons ages 51-61 with musculoskeletal and nonmusculoskeletal conditions in the US, 1992-94. Arthr Rheum. 1999;42(4): 769-79.
3. DeChellis DMCortazzo MH.,Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy- Theory and evidence. Phys Med Rehab Pain Specialist. 2012;15(2):74-80.
4. Nejadnik H, Hui JH, Choong EPF, Tai BC, Lee EH. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation an observational cohort study. Am J Sports Med. 2010;38(6): 1110-6.
5. Ossendorf C, Steinwachs MR, Kreuz PC, et al. Autologous chondrocyte implantation (ACI) for the treatment of large and complex cartilage lesions of the knee. Sports Med Arthrosc Rehabil Ther Technol. 2011;3:11.
6. Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211-5.
7. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Phys. 2008;11(3):343-53.
8. Reeves KD, Hassanein K. Randomized prospective double-blind placebocontrolled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Alt Ther Health Med. 2000;6(2):68-80.
9. Reeves KD, Hassanein K. Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and trapeziometacarpal) joints: evidence of clinical efficacy. J Altern Complement Med. 2000;6(4):311-20.
10. Scarpone M, Rabago DP, Zgierska A, Arbogast G, Snell E. The efficacy of prolotherapy for lateral epicondylosis: a pilot study. Clin J Sport Med. 2008;18(3):248-54.
11. Yelland MJ, Sweeting KR, Lyftogt JA, Shu KN, Scuffham PA, Evans KA. Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis: a randomised trial. Br J Sports Med. 2011;45(5):421-8.
12. Kim WM, Lee HG, Jeong CW, Kim CM, Yoon MH. A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain. J Alt Comp Med. 2010;16(12):1285-90.
13. Dagenais S, Yelland MJ, Del Mar C, Schoene ML. Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev. Apr 18, 2007;(2): CD004059.
14. Rabago D, Zgierska A, Fortney L, et al. Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: results of a single-arm uncontrolled study with 1-year follow-up. J Altern Complement Med. 2012;18(4): 408-14.
15. Kon E, Buda R, Filardo G, et al. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):472-9.
16. Sanchez M, Anitua E, Azofra J, Aguirre JJ, Andia I. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008;26(5):910-3.
17. Wang W, Li B, Yang JZ, et al. The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. Biomaterials. 2010;31(34):8964-73.
18. Krings A, Rahman S, Huang S, Lu Y, Czernik PJ, Lecka-Czernik B. Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes. Bone. 2012;50(2):546-52.
19. Olmsted-Davis E, Gannon FH, Ozen M, et al. Hypoxic adipocytes pattern early heterotopic bone formation. Am J Pathol. 2007;170(2):620-32.
20. Matsumoto T, Okabe T, Ikawa T, et al. Articular cartilage repair with autologous bone marrow mesenchymal cells. J Cell Physiol. 2010;225(2): 291-85.
21. Chen FH, Rousche KT, Tuan RS. Technology Insight: adult stem cells in cartilage regeneration and tissue engineering. Nat Clin Pract Rheumatol. 2006;2(7):373-82.
22. Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003;48(12):3464-74.
23. Ankrum J, Karp JM. Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol Med. 2010;16(5):203-9.
24. Tögel F, Weiss K, Yang Y, Hu Z, Zhang P, Westenfelder C. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol. 2007;292(5):1626-35.
25. Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions-Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 2005;87(7):1430-7.
26. Goel A, Sangwan SS, Siwach RC, Ali AM. Percutaneous bone marrow grafting for the treatment of tibial non-union. Injury. 2005;36(1):203-6.
27. Sim R, Liang TS, Tay BK. Autologous marrow injection in the treatment of delayed and non-union in long bones. Singapore Med J. 1993;34(5):412-7.