High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial

Diabetologia

Volumn 59, Issue 1, 2016, Pages 56-66

  Cassidy, Sophie ^a,b   Thoma, Christian ^a   Hallsworth, Kate ^a,b   Parikh, Jehill ^a,b   Hollingsworth, Kieren G ^a,b   Taylor, Roy ^a,b   Jakovljevic, Djordje G ^a,b   Trenell, Michael I ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Fatty liver; Heart diseases; Left ventricle; MRI; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; METFORMIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BODY COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FATTY LIVER; FEMALE; GLYCEMIC CONTROL; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART STROKE VOLUME; HIGH INTENSITY INTERMITTENT TRAINING; HUMAN; LIPID STORAGE; MALE; METABOLIC REGULATION; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; AGED; BLOOD; CARDIOVASCULAR DISEASES; CHEMISTRY; COMPLICATION; DIABETES MELLITUS, TYPE 2; DIASTOLE; DIET; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HEART; KINESIOTHERAPY; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SYSTOLE;

AGED; BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DIASTOLE; DIET; EXERCISE; EXERCISE THERAPY; FATTY LIVER; FEMALE; GLUCOSE TOLERANCE TEST; HEART; HUMANS; HYPOGLYCEMIC AGENTS; MAGNETIC RESONANCE IMAGING; MALE; METFORMIN; MIDDLE AGED; SYSTOLE;

EID: 84949231270     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3741-2     Document Type: Article

References (48)

1. IDF (2013) International Diabetes Federation Diabetes Atlas, 6th edn. IDF, Brussels
2. Reis SE, Holubkov R, Edmundowicz D et al (1997) Treatment of patients admitted to the hospital with congestive heart failure: specialty-related disparities in practice patterns and outcomes. J Am Coll Cardiol 30:733–738
3. Health and Social Care Information Centre (2013) National Diabetes Audit 2012–2013. Report 2: Complications and Mortality. HSCIC, Leeds, pp 1–25
4. Dawson A, Morris AD, Struthers AD (2005) The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus. Diabetologia 48:1971–1979
5. Rijzewijk LJ, van der Meer RW, Lamb HJ et al (2009) Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging. J Am Coll Cardiol 54:1524–1532
6. Cassidy S, Hallsworth K, Thoma C et al (2015) Cardiac structure and function are altered in type 2 diabetes and non-alcoholic fatty liver disease and associate with glycemic control. Cardiovasc Diabetol 14:23
7. Diamant M, Lamb HJ, Groeneveld Y et al (2003) Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol 42:328–335
8. Fonseca CG, Dissanayake AM, Doughty RN et al (2004) Three-dimensional assessment of left ventricular systolic strain in patients with type 2 diabetes mellitus, diastolic dysfunction, and normal ejection fraction. Am J Cardiol 94:1391–1395
9. Grothues F, Smith GC, Moon JCC et al (2002) Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol 90:29–34
10. Inzucchi SE, Bergenstal RM, Buse JB et al (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35:1364–1379
11. Chudyk A, Petrella RJ (2011) Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis. Diabetes Care 34:1228–1237
12. Gibala MJ, Little JP, Macdonald MJ, Hawley JA (2012) Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 590:1077–1084
13. Wisløff U, Støylen A, Loennechen JP et al (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115:3086–3094
14. Hollekim-Strand SM, Bjørgaas MR, Albrektsen G et al (2014) High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction: a randomized controlled trial. J Am Coll Cardiol 64:1758–1760
15. Mitranun W, Deerochanawong C, Tanaka H, Suksom D (2014) Continuous vs interval training on glycemic control and macro-and microvascular reactivity in type 2 diabetic patients. Scand J Med Sci Sports 24:e69–e76
16. Björntorp P (1991) Metabolic implications of body fat distribution. Diabetes Care 14:1132–1143
17. Taylor R (2013) Type 2 diabetes: etiology and reversibility. Diabetes Care 36:1047–1055
18. ACSM, Thompson WR, Gordon NF, Pescatello LS (2010) ACSM’s guidelines for exercise testing and prescription, 8th edn. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia
19. Gratze G, Fortin J, Holler A et al (1998) A software package for non-invasive, real-time beat-to-beat monitoring of stroke volume, blood pressure, total peripheral resistance and for assessment of autonomic function. Comput Biol Med 28:121–142
20. Jones DEJ, Hollingsworth K, Fattakhova G et al (2010) Impaired cardiovascular function in primary biliary cirrhosis. Am J Physiol Gastrointest Liver Physiol 298:G764–G773
21. Hollingsworth KG, Blamire AM, Keavney BD, Macgowan GA (2012) Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol 302:H885–H892
22. Schär M, Vonken E-J, Stuber M (2010) Simultaneous B(0)-and B(1)+-map acquisition for fast localized shim, frequency, and RF power determination in the heart at 3T. Magn Reson Med 63:419–426
23. Vanhamme L, Van Huffel S, Van Hecke P, van Ormondt D (1999) Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals. J Magn Reson 140:120–130
24. Bottomley PA (2009) NMR spectroscopy of the human heart. eMagRes. doi:10.1002/9780470034590.emrstm0345.pub2
25. Szczepaniak LS, Nurenberg P, Leonard D et al (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288:E462–E468
26. Shen W, Punyanitya M, Wang Z et al (2004) Visceral adipose tissue: relations between single-slice areas and total volume. Am J Clin Nutr 80:271–278
27. Donnelly LF, O’Brien KJ, Dardzinski BJ et al (2003) Using a phantom to compare MR techniques for determining the ratio of intraabdominal to subcutaneous adipose tissue. AJR Am J Roentgenol 180:993–998
28. Abramoff MD, Magalhães PJ, Ram SJ (2004) Image processing with ImageJ. Biophoton Int 11:36–42
29. Levy JC, Matthews DR, Hermans MP (1998) Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21:2191–2192
30. Floch J-P, Escuyer P, Baudin E et al (1990) Blood glucose area under the curve. Methodological aspects. Diabetes Care 13:172–175
31. Borg GAV (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377–381
32. St-Onge M, Mignault D, Allison DB, Rabasa-Lhoret R (2007) Evaluation of a portable device to measure daily energy expenditure. Am J Clin Nutr 742–749
33. Thomas DE, Elliott EJ, Naughton GA (2006) Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev, Issue 3, Art. no.: CD002968. doi:10.1002/14651858.CD002968.pub2
34. Rothman KJ (1990) No adjustments are needed for multiple comparisons. Epidemiology 1:43–46
35. Frey N, Katus HA, Olson EN, Hill JA (2004) Hypertrophy of the heart: a new therapeutic target? Circulation 109:1580–1589
36. Liao Y, Cooper RS, McGee DL et al (1995) The relative effects of left ventricular hypertrophy, coronary artery disease, and ventricular dysfunction on survival among black adults. JAMA 273:1592–1597
37. Kemi OJ, Haram PM, Loennechen JP et al (2005) Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res 67:161–172
38. Halley CM, Houghtaling PL, Khalil MK et al (2011) Mortality rate in patients with diastolic dysfunction and normal systolic function. Arch Intern Med 171:1082–1087
39. Hordern MD, Coombes JS, Cooney LM et al (2009) Effects of exercise intervention on myocardial function in type 2 diabetes. Heart 95:1343–1349
40. Lumens J, Delhaas T, Arts T et al (2006) Impaired subendocardial contractile myofiber function in asymptomatic aged humans, as detected using MRI. Am J Physiol Heart Circ Physiol 291:H1573–H1579
41. Babraj JA, Vollaard NBJ, Keast C et al (2009) Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr Disord 9:3
42. Gillen JB, Percival ME, Ludzki A et al (2013) Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obesity (Silver Spring) 21:2249–2255
43. Lim EL, Hollingsworth KG, Aribisala BS et al (2011) Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 54:2506–2514
44. Little JP, Gillen JB, Percival ME et al (2011) Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol 111:1554–1560
45. Gillen JB, Little JP, Punthakee Z et al (2012) Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes Obes Metab 14:575–577
46. Weiss RG, Gerstenblith G, Bottomley PA (2005) ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci U S A 102:808–813
47. Scheuermann-Freestone M, Madsen PL, Manners D et al (2003) Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation 107:3040–3046
48. Colberg SR, Swain DP, Vinik AI (2003) Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic. Diabetes Care 26:986–990